VALIDATION OF MRI PERFUSION TECHNIQUES

MRI 灌注技术的验证

• 批准号: 2635797
• 负责人: CRAIG A BRANCH
• 金额: $ 20.15万
• 依托单位: NATHAN S. KLINE INSTITUTE FOR PSYCH RES
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-05-01 至 2002-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2635797
• 关键词: blood flow measurement; diagnosis quality /standard; laboratory rat; magnetic resonance imaging; radioactive microsphere technique; vasomotion

DESCRIPTION (Adapted from Applicant's Abstract): Magnetic Resonance Imaging (MRI) techniques, are rapidly being developed to allow for the quantitative assessment of cerebral blood flow (CBF) in both experimental animals and man. These MRI-based methods offer many advantages over other techniques like inert Xe131-CT, or H2O15 PET, because they are non-invasive and can be acquired registered to high resolution anatomical, functional, and spectroscopic images of cerebral metabolism. These new MRI-based methods of perfusion assessment are based upon the arterial spin labeling technique first introduced by Williams et. al. and include EPISTAR, FAIR, UNFAIR and QUIPPS. These techniques are just beginning to be applied in the clinical setting, and although they are very promising, there is a need to validate these methods and to examine the sources of error in their use. The applicants proposed to systematically investigate the sources of error of these techniques including estimates of transit times and partition coefficients, arterial relaxation times and magnetization transfer effects. They would also compare the estimates of cerebral perfusion obtained with these MR-based techniques with the well established technique of CBF measurement using intracardiac bolus injection of labeled microspheres. These studies would be conducted in nonpathologic normally perfused brain, and under ischemic conditions using middle cerebral artery occlusion in rats. This work could improve the reliability of MRI based measurements of cerebral perfusion and would, therefore, provide for their routine application in clinical and research settings.

描述(摘自申请者摘要)：磁共振成像 (核磁共振)技术，正在迅速发展，以允许量化 两种实验动物脑血流量(CBF)的测定 天哪。与其他技术相比，这些基于MRI的方法具有许多优势 像惰性Xe131-CT或H_2O_15 PET，因为它们是非侵入性的，可以 获得注册到高分辨率的解剖、功能和 大脑新陈代谢的光谱图像。这些基于MRI的新方法 血流灌注评估基于动脉自旋标记技术。 首先由Williams et介绍。艾尔包括Eistar、公平、不公平和 吉普斯。这些技术才刚刚开始应用于临床。 虽然它们非常有希望，但仍需要验证 这些方法并检查其使用中的误差来源。这个 申请人建议系统地调查错误的来源 这些技术包括运输时间和分区的估计 系数、动脉松弛时间和磁化传递效应。 他们还会将获得的脑血流灌注估计值与 这些基于MR的技术与CBF技术相结合 心内注射标记微球进行测量。 这些研究将在非病理性正常灌流的大脑中进行， 在缺血条件下采用大脑中动脉闭塞的方法 老鼠。这项工作可以提高基于MRI的测量的可靠性 脑灌注，因此，将为他们的日常生活提供 在临床和研究环境中的应用。