7.0 Tesla Upgrade for Basic Psychiatric Research

7.0 Tesla 升级用于基础精神病学研究

• 批准号: 7213155
• 负责人: CRAIG A BRANCH
• 金额: $ 50万
• 依托单位: NATHAN S. KLINE INSTITUTE FOR PSYCH RES
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-06-01 至 2009-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7213155
• 关键词: Aging; Alzheimer' s Disease; Amplifiers; Amyloid deposition; Animal Model; Antipsychotic Agents; Architecture; Basic Science; Brain; Brain imaging; Caring; Complex; Diffusion; Disease; Electrodes; Financial Support; Frequencies; Functional Imaging; Functional Magnetic Resonance Imaging; Functional disorder; Funding; Image; In Vitro; Institutes; Investigation; Magnetic Resonance Imaging; Mental disorders; Metabolic Pathway; Mission; Modeling; Operative Surgical Procedures; Pharmaceutical Preparations; Physiological; Placement; Primates; Purpose; RF coil; Radio; Request for Proposals; Research; Research Personnel; Resolution; Resources; Rodent; Schizophrenia; Spectrum Analysis; Structure; Substance abuse problem; Tauopathies; Technology; Tissues; Transgenic Organisms; United States National Institutes of Health; base; design; drug of abuse; improved; neuroimaging; novel; programs; research facility

DESCRIPTION (provided by applicant): The Center for Advanced Brain Imaging (CABI) is a multi-disciplinary MRI-based research facility within the Nathan S. Kline Institute for Psychiatric Research (NKI). The CABI is an MRI- centered image acquisition and analysis facility whose purpose is to support all investigators within and outside NKI in the pursuit of research relevant to the Institutes' mission. The mission of NKI is to improve care for people suffering from complex, psychobiologically based severely disabling mental disorders, such as Alzheimer's disease and Schizophrenia. The High Field 7.0 Tesla MRI/MRS facility located within the CABI serves the mission of NKI by providing high resolution and novel imaging resources to NIH projects that employ translational animal models or in vitro tissues to investigate the pathological consequences of psychobiologically based diseases. Current funded NIH programs utilizing the center include those centered upon Alzheimer's disease, Schizophrenia and Tauopathy diseases, as well as basic research into the physiological basis of functional imaging, diffusion contrast and metabolic pathways of substance abuse. The facility supports novel transgenic rodent and primate models that investigate the pathophysiology of beta-amyloid deposition, schizophrenia, the effect of antipsychotic medications and drugs of abuse upon brain structure and the physiological basis of functional magnetic resonance imaging. The facility also provides pre- and post-surgical imaging to assist in precise electrode placement for electrophysiological studies using animal models of psychiatric disease. This proposal requests financial support to replace the aging and unreliable SMIS broadband spectrometer with a new Varian Inc. DirecDrive Architecture broadband and multi-channel spectrometer, including radio frequency and gradient amplifiers. The existing magnet (40 centimeter bore 7 Tesla superconducting magnet, manufactured by Magnex Scientific), its shielding, two novel actively-shielded imaging and spectroscopy gradient sets (10 cm - 500 mT/m and 28 cm 100 mT/m) designed for rodent and primate imaging respectively and recently purchased RF coil and switching technology will be retained. This support will directly impact upon the long term ability of NKI and CABI to support NIH funded investigations dependent on neuroimaging of animal models of Alzheimer's Disease, Schizophrenia and other mental health disorders.

描述（由申请人提供）：高级脑成像中心（CABI）是内森·s·克莱恩精神病学研究所（NKI）内一个基于核磁共振的多学科研究机构。CABI是一个以核磁共振成像为中心的图像采集和分析设施，其目的是支持NKI内外的所有研究人员进行与研究所使命相关的研究。NKI的使命是改善对患有复杂的、基于心理生物学的严重致残性精神障碍（如阿尔茨海默病和精神分裂症）的患者的护理。位于CABI内的高场7.0特斯拉MRI/MRS设备通过为NIH项目提供高分辨率和新颖的成像资源来服务于NKI的使命，这些项目使用翻译动物模型或体外组织来研究基于心理生物学的疾病的病理后果。目前NIH利用该中心资助的项目包括那些以阿尔茨海默病、精神分裂症和tau病为中心的项目，以及对功能成像、扩散对比和药物滥用代谢途径的生理基础的基础研究。该设施支持新型转基因啮齿动物和灵长类动物模型，研究β -淀粉样蛋白沉积的病理生理、精神分裂症、抗精神病药物和滥用药物对大脑结构的影响以及功能性磁共振成像的生理基础。该设施还提供术前和术后成像，以协助使用精神疾病动物模型进行电生理研究的精确电极放置。该提案要求财政支持，用新的瓦里安公司的宽带光谱仪取代老化和不可靠的SMIS光谱仪。DirecDrive架构宽带和多通道光谱仪，包括射频和梯度放大器。现有的磁体（40厘米直径7特斯拉超导磁体，由Magnex Scientific制造），其屏蔽，两种新型主动屏蔽成像和光谱梯度装置（10厘米- 500 mT/m和28厘米100 mT/m），分别用于啮齿动物和灵长类动物成像，以及最近购买的射频线圈和开关技术将被保留。这种支持将直接影响NKI和CABI支持NIH资助的研究的长期能力，这些研究依赖于阿尔茨海默病、精神分裂症和其他精神健康障碍的动物模型的神经成像。

项目成果

Aberrant development of intrinsic brain activity in a rat model of caregiver maltreatment of offspring.

• DOI: 10.1038/tp.2016.276
• 发表时间: 2017-01-17
• 期刊: Translational psychiatry
• 影响因子: 6.8
• 作者: Yan CG;Rincón-Cortés M;Raineki C;Sarro E;Colcombe S;Guilfoyle DN;Yang Z;Gerum S;Biswal BB;Milham MP;Sullivan RM;Castellanos FX
• 通讯作者: Castellanos FX

Histological correlation of diffusional kurtosis and white matter modeling metrics in cuprizone-induced corpus callosum demyelination.

• DOI: 10.1002/nbm.3140
• 发表时间: 2014-08
• 期刊: NMR in biomedicine
• 影响因子: 2.9
• 作者: Falangola MF;Guilfoyle DN;Tabesh A;Hui ES;Nie X;Jensen JH;Gerum SV;Hu C;LaFrancois J;Collins HR;Helpern JA
• 通讯作者: Helpern JA

Longitudinal magnetic resonance imaging reveals striatal hypertrophy in a rat model of long-term stimulant treatment.

• DOI: 10.1038/tp.2016.158
• 发表时间: 2016-09-06
• 期刊: Translational psychiatry
• 影响因子: 6.8
• 作者: Biezonski D;Shah R;Krivko A;Cha J;Guilfoyle DN;Hrabe J;Gerum S;Xie S;Duan Y;Bansal R;Leventhal BL;Peterson BS;Kellendonk C;Posner J
• 通讯作者: Posner J

Functional connectivity fMRI in mouse brain at 7T using isoflurane.

• DOI: 10.1016/j.jneumeth.2013.01.019
• 发表时间: 2013-04-15
• 期刊: JOURNAL OF NEUROSCIENCE METHODS
• 影响因子: 3
• 作者: Guilfoyle, David N.;Gerum, Scott V.;Sanchez, Jamie L.;Balla, Andrea;Sershen, Henry;Javitt, Daniel C.;Hoptman, Matthew J.
• 通讯作者: Hoptman, Matthew J.