VALIDATION OF MRI PERFUSION TECHNIQUES

MRI 灌注技术的验证

• 批准号: 6187858
• 负责人: CRAIG A BRANCH
• 金额: $ 21.38万
• 依托单位: NATHAN S. KLINE INSTITUTE FOR PSYCH RES
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-05-01 至 2002-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6187858
• 关键词: bioimaging /biomedical imaging; blood flow measurement; brain circulation; diagnosis quality /standard; laboratory rat; magnetic resonance imaging; radioactive microsphere technique; vasomotion

DESCRIPTION (Adapted from Applicant's Abstract): Magnetic Resonance Imaging (MRI) techniques, are rapidly being developed to allow for the quantitative assessment of cerebral blood flow (CBF) in both experimental animals and man. These MRI-based methods offer many advantages over other techniques like inert Xe131-CT, or H2O15 PET, because they are non-invasive and can be acquired registered to high resolution anatomical, functional, and spectroscopic images of cerebral metabolism. These new MRI-based methods of perfusion assessment are based upon the arterial spin labeling technique first introduced by Williams et. al. and include EPISTAR, FAIR, UNFAIR and QUIPPS. These techniques are just beginning to be applied in the clinical setting, and although they are very promising, there is a need to validate these methods and to examine the sources of error in their use. The applicants proposed to systematically investigate the sources of error of these techniques including estimates of transit times and partition coefficients, arterial relaxation times and magnetization transfer effects. They would also compare the estimates of cerebral perfusion obtained with these MR-based techniques with the well established technique of CBF measurement using intracardiac bolus injection of labeled microspheres. These studies would be conducted in nonpathologic normally perfused brain, and under ischemic conditions using middle cerebral artery occlusion in rats. This work could improve the reliability of MRI based measurements of cerebral perfusion and would, therefore, provide for their routine application in clinical and research settings.

描述（改编自申请人的摘要）：磁共振成像 （MRI）技术正在迅速发展，以允许定量 评估实验动物的脑血流量（CBF） 男人。 这些基于 MRI 的方法比其他技术具有许多优势 例如惰性 Xe131-CT 或 H2O15 PET，因为它们是非侵入性的并且可以 获得注册到高分辨率解剖学、功能性和 脑代谢的光谱图像。 这些基于 MRI 的新方法 灌注评估基于动脉自旋标记技术 首先由 Williams 等人提出。等人。包括晶元、公平、不公平和 奎普斯。 这些技术刚刚开始应用于临床 设置，虽然它们非常有前途，但需要验证 这些方法并检查其使用中的错误来源。 这 申请人建议系统地调查误差来源 这些技术包括运输时间和分区的估计 系数、动脉弛豫时间和磁化转移效应。 他们还将比较获得的脑灌注估计值 这些基于 MR 的技术与成熟的 CBF 技术相结合 使用心内推注标记微球进行测量。 这些研究将在非病理性正常灌注的大脑中进行， 并在缺血条件下使用大脑中动脉闭塞 老鼠。 这项工作可以提高基于 MRI 的测量的可靠性 脑灌注，因此可以满足他们的日常需要 在临床和研究环境中的应用。