3.0 Tesla MRI for Psychiatric Applications

用于精神病学应用的 3.0 特斯拉 MRI

• 批准号: 7125756
• 负责人: CRAIG A BRANCH
• 金额: $ 200万
• 依托单位: NATHAN S. KLINE INSTITUTE FOR PSYCH RES
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-05-01 至 2009-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7125756
• 关键词: Aging; Alzheimer' s Disease; Animals; Area; Arts; Attention; Base of the Brain; Basic Science; Brain; Brain imaging; Chronic Schizophrenia; Clinical; Cognition; Cognitive; Collection; Communities; Data; Dementia; Development; Diffusion; Diffusion Magnetic Resonance Imaging; Foundations; Functional Imaging; Functional Magnetic Resonance Imaging; Funding; Funding Mechanisms; Goals; Human; Image; Imaging technology; Institutes; Investigation; Longitudinal Studies; Magnetic Resonance Imaging; Maps; Measurement; Measures; Mental Health; Mental disorders; Methodology; Methods; New York; Noise; Perfusion; Pharmacotherapy; Physics; Physiological; Process; Protocols documentation; Protons; Research; Research Infrastructure; Resolution; Schizophrenia; Signal Transduction; Spectrum Analysis; Speed; Structure; Substance abuse problem; System; Testing; Tissues; United States National Institutes of Health; Vendor; Visual; base; brain research; instrumentation; man; mental health related disorder; neuropsychiatry; novel; patient oriented; research facility; sensory integration; somatosensory; spectroscopic imaging; stem

DESCRIPTION (provided by applicant): The Center for Advanced Brain Imaging (CABI) is a multi-disciplinary MRI-based research facility within the Nathan S. Kline Institute for Psychiatric Research (NKI), which is supported by the State of New York Office of Mental Health (OMH). The facilities within the CABI are 100% available for clinical and basic research. The Center supports brain research into mental health related disorders with emphasis upon Schizophrenia, Alzheimer's disease, dementia and aging and substance abuse. Basic imaging research includes the physiological basis of Diffusion Tensor Imaging (DTI), BOLD-fMRI and brain-based cognition, attention and sensory integration of function. Novel drug therapies for psychiatric illness are investigated. In all these areas of scientific inquiry, an overall theme is detected; the relationship between structures of the brain, as detected by structural brain imaging (anatomical MRI, contrast enhanced MRI and DTI) and the functional use and integrity of the tissues studied, detected with BOLD-fMRI, perfusion imaging, proton spectroscopy, or electrophysiological methods. The goal of this proposal is to make possible the acquisition of a research dedicated 3.0 Tesla MRI with parallel imaging technology and spectroscopic imaging capabilities, to accommodate ongoing NIH funded and planned research into the functional consequences and structural correlates psychiatric disease. This instrumentation, and the state-of-the-art parallel imaging methodology it provides will accelerate patient oriented imaging protocols, enhance spatial resolution and image acquisition speed and reduce geometric and intensity distortions to a manageable level while increasing signal-to-noise. These improvements will greatly facilitate our investigations into micro-structural and gross structural deficits, as well as the functional consequences of emerging, expressed and/or chronic Schizophrenia, Alzheimer's disease, dementia and substance abuse. Spectroscopic (metabolite) imaging, functional brain imaging and DTI, the central measures of use, will be greatly facilitated by this instrumentation due to their inherent sensitivity to SNR and speed. The infrastructure support required to manage a strong imaging center focused on neuropsychiatric research is already in place, including physics, technician and administrative support structures, as well as oversight and protocol facilitation and review processes. Support for testing of novel hypotheses stemming from existing NIH research is provided.

描述（由申请人提供）：高级脑成像中心（CABI）是内森S。克莱恩精神病学研究所（NKI），由纽约州精神卫生办公室（OMH）支持。CABI内的设施100%可用于临床和基础研究。该中心支持对精神健康相关疾病的大脑研究，重点是精神分裂症，阿尔茨海默病，痴呆症和衰老以及药物滥用。影像学基础研究包括弥散张量成像（DTI）、BOLD-fMRI和基于脑的认知、注意和感觉整合功能的生理基础。研究精神疾病的新型药物疗法。在所有这些科学研究领域，都检测到了一个总体主题;大脑结构之间的关系，如通过结构脑成像（解剖MRI，对比增强MRI和DTI）检测到的，以及所研究组织的功能使用和完整性，用BOLD-fMRI，灌注成像，质子光谱或电生理方法检测。该提案的目标是能够获得具有并行成像技术和光谱成像能力的研究专用3.0特斯拉MRI，以适应正在进行的NIH资助和计划的功能后果和结构相关精神疾病的研究。这种仪器及其提供的最先进的并行成像方法将加速面向患者的成像协议，提高空间分辨率和图像采集速度，并将几何和强度失真降低到可管理的水平，同时提高信噪比。这些改进将极大地促进我们对微观结构和总体结构缺陷的研究，以及对新出现的、表达的和/或慢性精神分裂症、阿尔茨海默病、痴呆和药物滥用的功能后果的研究。光谱（代谢物）成像，功能性脑成像和DTI，使用的核心措施，将大大方便了这种仪器，由于其固有的灵敏度，信噪比和速度。管理一个专注于神经精神研究的强大成像中心所需的基础设施支持已经到位，包括物理，技术人员和行政支持结构，以及监督和协议促进和审查流程。支持测试新的假设来自现有的NIH研究提供。

项目成果

Comparison of psychophysical, electrophysiological, and fMRI assessment of visual contrast responses in patients with schizophrenia.

• DOI: 10.1016/j.neuroimage.2012.11.019
• 发表时间: 2013-02-15
• 期刊: NeuroImage
• 影响因子: 5.7
• 作者: Calderone DJ;Martinez A;Zemon V;Hoptman MJ;Hu G;Watkins JE;Javitt DC;Butler PD
• 通讯作者: Butler PD