AGING AND IMPLICIT MEMORY--EVIDENCE FROM LESION STUDIES

提出了一项五年研究计划，旨在（1）进一步 表征内隐记忆的功能神经结构， 通过将特定的内隐记忆过程与 通过对局灶性脑梗死患者的研究， 神经损伤，（2）检查这些系统中的处理过程 随着时间的变化和进行性多灶性疾病， 正常老年人和阿尔茨海默病（AD）患者的研究。最近 局灶性病变和AD患者的结果表明， 可分离的神经系统，介导三种形式的内隐记忆， 可能存在两个视觉内隐记忆系统在研究1a中， 重复启动测试，被认为是选择性地调用处理， 这些内隐记忆系统，将被给予患者， 在枕骨的限定区域中的单个脑损伤， 颞叶顶叶或额叶新皮层在那些表现出 将使用MRI方案，通过 三维重建和渲染分析，将允许 根据脑回解剖学和Brodmann对病变进行详细说明 地区在研究1b中，患有局灶性枕叶病变的患者将 用于检验右枕叶介导和 一种视觉内隐记忆， 关于文字和图片的信息，左枕叶介导 一种联想型的视觉内隐记忆， 有关文字和图片的信息。在研究2中，纵向研究 AD患者内隐记忆的研究。在这项研究中，AD组 患者和正常年龄的受试者将从单一的、良好的- 特征队列来检验广泛的假设，即内隐 在可分离的存储器系统中发生的处理将具有 AD病程中的不同变化率。

A five-year program of research is proposed that aims to (1) further characterize the functional neural architecture of implicit memory for words and objects by linking specific implicit memory processes to specific neural systems through studies of patients with focal neurological damage, and (2) examine how processing in these systems changes as a function of time and progressive multi-focal disease through studies of normal aged and patients with Alzheimer's disease (AD). Recent findings with focal lesion and AD patients indicate that there may be separable neural systems that mediate three forms of implicit memory and that there may be two visual implicit memory systems. In Study 1a, repetition priming tests, thought to selectively invoke processing in these implicit memory systems, will be administered to patients with single brain lesions in circumscribed regions of either the occipital, temporal, parietal, or frontal neocortex. In patients who exhibit informative dissociations, an MRI protocol will be used that, through three-dimensional reconstruction and rendering analyses, will permit specification of the lesions in terms of gyral anatomy and Brodmann areas. In Study 1b, patients with focal occipital lobe lesions will be used to test the hypotheses that the right occipital lobe mediates and apperceptive kind of visual implicit memory that retains form-specific information about words and pictures and the left occipital lobe mediates an associative kind of visual implicit memory that retains categorical information about words and pictures. In Study 2, a longitudinal study of implicit memory in AD will be conducted. For this study, groups of AD patients and normal aged subjects will be selected from a single, well- characterized cohort to test the broad hypothesis that the implicit processing that occurs in dissociable memory systems will have differential rates of change across of the course of AD.