ALPHA ADRENERGIC REGULATION OF CARDIAC ION CHANNELS

心脏离子通道的 ALPHA 肾上腺素调节

• 批准号: 6055496
• 负责人: ROBERT D HARVEY
• 金额: $ 21.11万
• 依托单位: CASE WESTERN RESERVE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-09-01 至 2001-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6055496
• 关键词: alpha adrenergic receptor; beta adrenergic receptor; biological signal transduction; calcium channel; cardiac myocytes; chloride channels; cyclic AMP; electrophysiology; guinea pigs; membrane channels; pertussis toxin; phospholipase A2; phospholipase C; potassium channel; protein tyrosine kinase; receptor sensitivity

DESCRIPTION: Preliminary data from the PI's laboratory has demonstrated that activation of alpha-1 adrenergic receptors inhibits beta-adrenergic induced stimulation of cardiac ion channels, particularly the C1 channel. The project proposed to extend these observations to other ion channels and to delineate the mechanisms involved. The proposal has 3 specific aims: (1) The PI will determine if alpha-1 adrenergic activation inhibits beta-stimulation in a similar fashion for C1 currents, L-type Ca currents and delayed rectified K currents. (2) It will be determined if alpha-1 adrenergic stimulation exerts its effects by changing cAMP production or degradation or by interactions involving the beta receptor itself, such as facilitating receptor desensitizations (3) The pathway involved in these effects will be delineated by identifying the subtype of alpha-adrenergic receptor involved, assessing pertussis toxin sensitivity and investigating the possible roles of phospholipase C, phospholipase A2 and tyrosine kinases.

描述：PI实验室的初步数据已经证明