BONE MARROW CELL ADHESION MOLECULES
骨髓细胞粘附分子
基本信息
- 批准号:2886778
- 负责人:
- 金额:$ 38.36万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:1992
- 资助国家:美国
- 起止时间:1992-09-01 至 2002-04-30
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
The main objective of this project is to identify molecules which mediate
physical interactions between cells in bone marrow. While it is already
clear that multiple families of molecules are involved, particular
functions have only been tentatively assigned to a few cell adhesion
molecules. CD44 and hyaluronan (HA) represent one receptor-ligand pair
present in marrow and they being extensively studied as a model for
structure-junction relationships. Current experiments are aimed at
learning how posttranslational modifications of CD44 influence its
ability to recognize HA. A new cloning strategy was developed and used
to learn that at least seven stromal cell products can interact with pre-
B cells and that three of them promote clonal lymphocyte growth in the
presence of IL-7. The functional significance of these molecules is now
being explored and longer range experiments should identify even more
components of the bone marrow microenvironment. While these basic
studies focus on normal physiologic processes, there are likely to be
many implications for human disease. For example, an understanding of how
stem cells are normally immobilized in marrow can be helpful in
harvesting them for transplantation. Knowledge of how stem cells
recognize the unique endothelium of marrow may suggest ways to enhance
their engraftment. Molecules being studied in this project may
contribute to the attachment of poliovirus, the AIDS virus, feline
immunodeficiency virus and diphtheria toxin to cells. There is also
evidence for their involvement in a variety of inflammatory processes,
metastasis of tumor ells, transplant rejection and asthma. Therefore ,
attempts to treat such conditions may have undesirable effects on
function of bone marrow.
这个项目的主要目标是找出
骨髓细胞之间的物理相互作用。虽然它已经是
明确涉及多个分子家族,特别是
功能只是暂定地分配给少数细胞黏附
分子。CD44和透明质酸(HA)代表一对受体-配体
存在于骨髓中,并被广泛研究为
结构-连接关系。目前的实验旨在
了解CD44的翻译后修饰如何影响其
识别HA的能力。开发并使用了一种新的克隆策略
了解到至少有七种基质细胞产品可以与Pre
B细胞,其中三种细胞促进克隆性淋巴细胞生长
IL-7的存在。这些分子的功能意义现在是
正在探索和更远距离的实验应该会识别更多
骨髓微环境的组成部分。虽然这些基本的
研究的重点是正常的生理过程,很可能有
对人类疾病有很多影响。例如,了解如何
干细胞通常被固定在骨髓中可能有助于
采集它们进行移植。关于干细胞如何
识别独特的骨髓内皮细胞可能会建议增强
他们的嫁接。在这个项目中正在研究的分子可能
有助于附着脊髓灰质炎病毒、艾滋病病毒、猫
免疫缺陷病毒和白喉毒素对细胞的作用。还有就是
有证据表明它们参与了各种炎症过程,
肿瘤细胞转移、移植排斥和哮喘。因此,
治疗此类疾病的尝试可能会对
骨髓功能。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
Paul Wayne Kincade其他文献
Paul Wayne Kincade的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('Paul Wayne Kincade', 18)}}的其他基金
Early Events in Mammalian B-Cell Differentiation
哺乳动物 B 细胞分化的早期事件
- 批准号:
7925000 - 财政年份:2009
- 资助金额:
$ 38.36万 - 项目类别:
Scientific Core: Flow Cytometry and Sorting Core Facility
科学核心:流式细胞术和分选核心设施
- 批准号:
7696191 - 财政年份:2009
- 资助金额:
$ 38.36万 - 项目类别:
Early Events in Mammalian B-Cell Differentiation
哺乳动物 B 细胞分化的早期事件
- 批准号:
7814397 - 财政年份:2009
- 资助金额:
$ 38.36万 - 项目类别:
EARLY EVENTS IN MAMMALIAN B-CELL DIFFERENTIATION
哺乳动物 B 细胞分化的早期事件
- 批准号:
7203357 - 财政年份:2005
- 资助金额:
$ 38.36万 - 项目类别:
BD FACSARIA DESKTOP CELL SORTER: ADULT HUMAN & ADULT MOUSE STEM CELLS,
BD FACSARIA 台式细胞分选仪:成人
- 批准号:
6973376 - 财政年份:2004
- 资助金额:
$ 38.36万 - 项目类别:
Developmental Stage-Related Changes in Lymphopoiesis
发育阶段相关的淋巴细胞生成变化
- 批准号:
7003696 - 财政年份:2004
- 资助金额:
$ 38.36万 - 项目类别:
Developmental Stage-Related Changes in Lymphopoiesis
发育阶段相关的淋巴细胞生成变化
- 批准号:
7354075 - 财政年份:2004
- 资助金额:
$ 38.36万 - 项目类别:
相似海外基金
ROLE OF CELL ADHESION IN BIOLOGICAL SIGNAL TRANSDUCTION
细胞粘附在生物信号转导中的作用
- 批准号:
6238317 - 财政年份:1997
- 资助金额:
$ 38.36万 - 项目类别:
ROLE OF CELL ADHESION IN BIOLOGICAL SIGNAL TRANSDUCTION
细胞粘附在生物信号转导中的作用
- 批准号:
5210031 - 财政年份:
- 资助金额:
$ 38.36万 - 项目类别: