NEURAL SUBSTRATES AND COGNITIVE EFFECTS OF MARIJUANA

大麻的神经基质和认知效应

• 批准号: 2772531
• 负责人: CHRISTOPHER T WHITLOW
• 金额: $ 4.22万
• 依托单位: WAKE FOREST UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-03-01 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/2772531
• 关键词: autoradiography; cannabinoid receptor; clinical research; cognition; cognition disorders; drug administration rate /duration; functional magnetic resonance imaging; human subject; laboratory rat; marijuana abuse; neuropharmacology; neuropsychological tests; urinalysis

DESCRIPTION: (Applicant's Abstract) Marijuana is the most frequently used illicit substance in our society. The neurobiological mechanisms underlying the neuropsychological effects of are still poorly understood, and effective strategies to treat the approximately lOO,OOO individuals admitted to treatment every year for marijuana use are lacking. New evidence suggests that marijuana produces changes in the brain that are similar to those observed following chronic use of harder drugs, implicating marijuana as a possible gateway drug (Tanda et al., 1997 and Rodriguez de Fonseca et al., 1997). Additional research needs to be conducted to assess the impairment of cognitive/decision making abilities, as such impairments may be particularly salient to the potential for escalated drug use. Although several studies have addressed the cognitive effects of marijuana, the anatomical distribution and underlying mechanisms of these effects have received little attention. Therefore, the aims of the proposed study are to use neuroimaging methods: 2-[14C]deoxyglucose, CB1 receptor, and [35S]GTPyS autoradiography (in rodents), as well as functional magnetic resonance imaging (in humans), to (1) investigate the dose-dependent, time-dependent, and residual effects of acute and chronic marijuana on brain activity in the rat using treatment regimens that have previously been associated with cognitive impairment, and to (2) determine the neurobiological substrates directly related to impaired performance of cognitive tasks, demonstrated in humans who frequently use marijuana.

描述：（申请人的摘要） 大麻是我们社会中最常用的非法物质。 这 神经心理学效应的神经生物学机制是 仍然很了解，以及对治疗大约对待的有效策略 Loo，OOO个人每年接受治疗大麻的治疗是 缺乏。 新证据表明大麻会在大脑中发生变化 与长期使用较硬药物后观察到的相似 将大麻视为可能的门户药物（Tanda等，1997和 Rodriguez de Fonseca等，1997）。 需要其他研究 进行评估认知/决策能力的损害， 由于这种损害可能特别重要 升级的吸毒。 尽管几项研究已经解决了认知 大麻的影响，解剖学分布和潜在机制 这些影响很少受到关注。 因此， 拟议的研究是使用神经影像学方法：2- [14C]脱氧葡萄糖，CB1 受体和[35s] GTPYS放射自显影（在啮齿动物中）以及功能性 磁共振成像（在人类中），（1）研究 剂量依赖性，时间依赖性和急性和慢性的残余作用 使用具有的治疗方案的大麻对大鼠活动的大麻 以前与认知障碍有关，并且（2）确定 神经生物学底物与性能受损直接相关 经常使用大麻的人类证明的认知任务。