Imaging

影像学

• 批准号: 10220888
• 负责人: CHRISTOPHER T WHITLOW
• 金额: $ 18.47万
• 依托单位: WAKE FOREST UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-08-17 至 2023-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10220888
• 关键词: Animals; Biodistribution; Brain Neoplasms; Catheters; Cessation of life; Collaborations; Contrast Media; Convection; Cyclotrons; Diagnosis; Discipline of Nuclear Medicine; Doctor of Philosophy; Drug Delivery Systems; Ensure; Equipment; Evaluation; Glioblastoma; Goals; Growth; Image; Laboratories; Leadership; Lesion; Magnetic Resonance Imaging; Malignant - descriptor; Malignant Glioma; Malignant neoplasm of brain; Medical; Methods; Modeling; Multimodal Imaging; Patients; Pharmaceutical Preparations; Physicians; Play; Positron-Emission Tomography; Pre-Clinical Model; Radiochemistry; Recording of previous events; Research; Research Personnel; Resource Sharing; Resources; Role; Route; Services; Strategic Planning; Structure; Techniques; Technology; Therapeutic; Therapeutic Uses; Time; United States; Visualization; Work; clinically relevant; drug distribution; experience; forest; imaging modality; in vivo; innovation; microPET/CT; molecular imaging; neuro-oncology; new therapeutic target; non-invasive imaging; novel; novel therapeutics; pre-clinical; radiotracer; response; targeted treatment; tumor

Advanced imaging plays a vital role in neuro-oncology research. The goal of this Imaging Core, Core 4, is to provide expertise and access to advanced imaging equipment required by the various projects of this P01 proposal. The objective of the Core is to organize the needs of Projects 1-4 and match them with the requisite know-how and advanced technology. We will accomplish our objectives in three specific aims: Specific Aim 1: To utilize non-invasive imaging to diagnose GBM, evaluate longitudinal progression, and response to therapy. Specific Aim 2: To directly radiolabel our novel targeted therapeutics and evaluate long-term biodistribution and tumor targeting. Specific Aim 3: To image loco-regional therapy administration to ensure proper placement of our advanced delivery vehicles and proper therapeutic distribution. Thus, Core 4 will provide indispensable services to all Projects in this PPG application. It will comply with one of the most important requirements in developing efficient drug delivery means by offering direct visualization of malignant lesions, access of drugs to these lesions and changes in their response to therapy. Core 4 integration with all the projects represents a considerable strength of our PPG application.

先进的成像技术在神经肿瘤学研究中起着至关重要的作用。这个成像核心，核心4，的目标是 提供本P01各项目所需的专业知识和先进成像设备 提议核心的目标是组织项目1-4的需求，并将其与必要的 知识和先进技术。我们将在三个具体目标中实现我们的目标：具体目标1： 利用非侵入性成像诊断GBM，评估纵向进展和对 疗法具体目标2：直接放射性标记我们的新型靶向治疗药物，并评估长期疗效。 生物分布和肿瘤靶向。具体目标3：对局部区域治疗给药进行成像， 确保我们先进的运载工具的正确放置和适当的治疗分配。因此，在本发明中， 核心4将为PPG申请中的所有项目提供不可或缺的服务。它将符合其中一个 在开发有效的药物递送手段中最重要的要求是通过提供直接的可视化， 恶性病变、药物进入这些病变的途径及其对治疗反应的变化。芯4 与所有项目的集成代表了我们PPG应用程序的相当大的优势。