GENETIC MECHANISMS IN EXPERIMENTAL PANCREATIC CANCER
实验性胰腺癌的遗传机制
基本信息
- 批准号:2700774
- 负责人:
- 金额:$ 23.43万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:1998
- 资助国家:美国
- 起止时间:1998-09-01 至 2003-06-30
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
DESCRIPTION: The overall objective of the studies proposed herein is
the development of animal models that will then be used to examine the
genetic basis of exocrine pancreatic cancer. Pancreatic cancer is the
fourth most lethal cancer in the human population. It is typically
diagnosed at an inoperable stage so that long term patient survival is
exceptionally low. Increased understanding of the molecular pathogenesis
of this disease may form a necessary foundation for attempts to reverse
the poor prognosis. The development of transgenic animal technology has
permitted the establishment of models of complex genetic diseases like
cancer for which the effects of selected genetic alterations can be
correlated with specific pathophysio-logical consequences in vivo.
However, the transgenic approach has had several technical limitations,
including lack of inducible systems for targeting transgene expression
and the down regulation of transgene transcriptional regulatory elements
in certain experimental contexts, such as neoplastic progression. The
studies proposed in the application employ two recent advances in
transgenic methodology, the tetracycline responsive system and the
cre/lox recombinase system, to create models of exocrine pancreatic
neoplasia that avoid the limitation described above and that should more
closely reflect the etiological mechanisms believed to cause this
disease in the human population. These models are then used to
characterize the pathogenetic basis of the disease. The specific aims
are: (1) establish animal models of ductal neoplasia that reproduce the
ductal origin of this cancer in humans; (2) characterize the pathogenic
effects of genetic alterations that have been associated with the
development and progression of exocrine pancreatic cancer in humans; and
(3) determine, between species, the comparative pathogenicity of cancer-
related genetic alterations. The final aim generation of transgenic rat
models of exocrine pancreatic cancer, addresses the fact that we must
continually reason by analogy from one species to another when using
animal models to study human disease. The goal of this aim is to
directly compare, between species, the pathophysiological responses to
identical, precisely defined genetic alterations.
描述:本文提出的研究的总体目标是
动物模型的发展,然后将用于检查
外分泌胰腺癌的遗传基础 胰腺癌是一种
是人类第四致命的癌症 它通常
在不能手术的阶段就被诊断出来,
异常低。增加对分子发病机制的了解
这种疾病的可能形成一个必要的基础,试图扭转
预后不佳。 转基因动物技术的发展,
允许建立复杂遗传疾病的模型,
选择性遗传改变的影响可能是
与体内特定的病理生理后果相关。
然而,转基因方法有几个技术限制,
包括缺乏用于靶向转基因表达的诱导系统
以及转基因转录调控元件的下调
在某些实验背景下,如肿瘤进展。 的
该申请中提出的研究采用了两项最新进展,
转基因方法、四环素反应系统和
cre/lox重组酶系统构建胰腺外分泌模型
避免上述限制并且应该更多的肿瘤
密切反映了被认为是导致这种情况的病因学机制,
人类的疾病。 这些模型用于
描述疾病的发病基础。 具体目标
(1)建立乳腺导管瘤动物模型,
这种癌症在人类中的导管起源;(2)表征致病性
基因改变的影响,已经与
人类外分泌胰腺癌的发展和进展;以及
(3)确定不同物种之间癌症的相对致病性
相关的基因突变。 转基因大鼠的最终目标代
外分泌胰腺癌的模型,解决了一个事实,我们必须
当使用时,不断地从一个物种类比到另一个物种。
研究人类疾病的动物模型。 这一目标的目的是
直接比较,种属之间,
相同的精确定义的基因改变
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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{{ truncateString('ERIC P SANDGREN', 18)}}的其他基金
QUANTIFYING GENE EFFECTS ON HEPATIC CANCER IN VIVO
体内量化基因对肝癌的影响
- 批准号:
7120265 - 财政年份:2006
- 资助金额:
$ 23.43万 - 项目类别:
Quantifying Gene Effects on Hepatic Cancer in Vivo
体内量化基因对肝癌的影响
- 批准号:
6884900 - 财政年份:2004
- 资助金额:
$ 23.43万 - 项目类别:
Quantifying Gene Effects on Hepatic Cancer in Vivo
体内量化基因对肝癌的影响
- 批准号:
6706514 - 财政年份:2004
- 资助金额:
$ 23.43万 - 项目类别:
Quantifying Gene Effects on Hepatic Cancer in Vivo
体内量化基因对肝癌的影响
- 批准号:
7046088 - 财政年份:2004
- 资助金额:
$ 23.43万 - 项目类别:
Genetic Mechanisms in Experimental Pancreatic Cancer
实验性胰腺癌的遗传机制
- 批准号:
6870021 - 财政年份:1998
- 资助金额:
$ 23.43万 - 项目类别:
Genetic Mechanisms in Experimental Pancreatic Cancer
实验性胰腺癌的遗传机制
- 批准号:
7356399 - 财政年份:1998
- 资助金额:
$ 23.43万 - 项目类别:
GENETIC MECHANISMS IN EXPERIMENTAL PANCREATIC CANCER
实验性胰腺癌的遗传机制
- 批准号:
6173357 - 财政年份:1998
- 资助金额:
$ 23.43万 - 项目类别:
GENETIC MECHANISMS IN EXPERIMENTAL PANCREATIC CANCER
实验性胰腺癌的遗传机制
- 批准号:
6513323 - 财政年份:1998
- 资助金额:
$ 23.43万 - 项目类别:
GENETIC MECHANISMS IN EXPERIMENTAL PANCREATIC CANCER
实验性胰腺癌的遗传机制
- 批准号:
2896266 - 财政年份:1998
- 资助金额:
$ 23.43万 - 项目类别:
Genetic Mechanisms in Experimental Pancreatic Cancer
实验性胰腺癌的遗传机制
- 批准号:
7056122 - 财政年份:1998
- 资助金额:
$ 23.43万 - 项目类别:
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