BREAST MICROCALCIFICATION VISUALIZATION WITH ULTRASOUND
超声乳腺微钙化可视化
基本信息
- 批准号:2446829
- 负责人:
- 金额:$ 14.17万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:1998
- 资助国家:美国
- 起止时间:1998-06-01 至 2001-05-31
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
DESCRIPTION (Adapted from Applicant's Abstract): Microcalcifications are
important diagnostic indicators in the mammographic screening of the breast.
Currently, conventional x-ray mammography is the gold standard for the
detection and diagnosis of microcalcifications. However, the efficacy of
conventional mammography can be significantly reduced in the presence of
dense breast parenchyma, which is found in approximately one in four women.
Breast ultrasound is a powerful adjunct to mammography, but its role in the
breast clinic is fundamentally limited by the inability of current
ultrasound technology to reliably visualize microcalcifications. The
improved visualization of microcalcifications with ultrasound would have a
significant impact on the management of breast cancer by contributing
diagnostic information in mammographically challenging cases and potentially
reducing the number of unnecessary biopsies. Despite the rapid development
of the state of the art of medical ultrasound, the optimization of
ultrasound system design with regard to microcalcification visualization has
not been investigated. The long term objective of the proposed research is
to improve the visualization of microcalcifications in the breast with
medical ultrasound. Using techniques that they have developed and
implemented, the applicants proposed to conduct in excised tissue and in
vivo studies to collect high quality ultrasound data from
microcalcifications and breast tissue. These data will be used to
characterize the backscatter properties of microcalcifications and breast
tissue, to test the validity of the modeling of microcalcifications with the
classical Faran model, to measure phase aberration in the breast, and to
assess the relative impact of several physical factors on the visualization
of microcalcifications. These factors will be speckle noise, spatial
resolution, and phase aberration. Empirical and model results will be used
to evaluate the relative efficacy of several proposed means to improve
visualization, and to specify the ultrasound system performance criterion
required to achieve reliable visualization. In vitro studies will also be
undertaken to assess the potential of harmonic imaging techniques to improve
microcalcification visualization. It is hypothesized that the optimization
of system design parameters will improve the visualization of
microcalcifications with ultrasound.
描述(改编自申请人的摘要):微钙化是
乳腺X线摄影筛查的重要诊断指标。
目前,传统的 X 射线乳房 X 线摄影是乳腺 X 线检查的黄金标准。
微钙化的检测和诊断。 然而,功效
传统的乳房X光检查可以在存在
致密的乳房实质,大约四分之一的女性存在这种情况。
乳房超声检查是乳房 X 光检查的有力辅助手段,但其作用
乳腺诊所从根本上限制了当前的能力
超声技术可可靠地观察微钙化。 这
通过超声波改善微钙化的可视化将有
通过贡献对乳腺癌的管理产生重大影响
乳腺X光检查具有挑战性的病例中的诊断信息和潜在的
减少不必要的活检数量。 尽管发展迅速
最先进的医学超声技术,优化
关于微钙化可视化的超声系统设计
没有被调查。 拟议研究的长期目标是
改善乳房微钙化的可视化
医学超声波。 使用他们开发的技术和
实施后,申请人建议在切除的组织中进行
体内研究收集高质量的超声数据
微钙化和乳腺组织。 这些数据将用于
表征微钙化和乳房的反向散射特性
组织,以测试微钙化模型的有效性
经典法兰模型,测量乳房的相位像差,并
评估几个物理因素对可视化的相对影响
的微钙化。 这些因素将是散斑噪声、空间
分辨率和相位差。 将使用经验和模型结果
评估几种提出的改进方法的相对功效
可视化,并指定超声系统性能标准
实现可靠的可视化所需的。 体外研究也将
旨在评估谐波成像技术改善的潜力
微钙化可视化。 假设优化
系统设计参数的可视化将提高
超声微钙化。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Gregg E. Trahey其他文献
Off-axis scatterer filters for improved aberration measurements
离轴散射滤光片可改善像差测量
- DOI:
- 发表时间:
2003 - 期刊:
- 影响因子:0
- 作者:
Jeremy J. Dahl;Gregg E. Trahey - 通讯作者:
Gregg E. Trahey
Potential and limitations of angle-independent flow detection algorithms using radio-frequency and detected echo signals.
使用射频和检测到的回波信号的与角度无关的流量检测算法的潜力和局限性。
- DOI:
10.1016/0161-7346(91)90075-s - 发表时间:
1991 - 期刊:
- 影响因子:2.3
- 作者:
B. S. Ramamurthy;Gregg E. Trahey - 通讯作者:
Gregg E. Trahey
Phase Aberration Correction Using Echo Signals from Moving Targets I: Description and Theory
使用来自移动目标的回波信号进行相位像差校正 I:描述和理论
- DOI:
- 发表时间:
1992 - 期刊:
- 影响因子:0
- 作者:
D. Zhao;L. Bohs;Gregg E. Trahey - 通讯作者:
Gregg E. Trahey
Phased array ultrasound imaging through planar tissue layers.
通过平面组织层进行相控阵超声成像。
- DOI:
- 发表时间:
1986 - 期刊:
- 影响因子:2.9
- 作者:
Stephen W. Smith;Stephen W. Smith;Gregg E. Trahey;O. Ramm - 通讯作者:
O. Ramm
Experimental results with a real-time adaptive ultrasonic imaging system for viewing through distorting media
用于透过扭曲介质观察的实时自适应超声成像系统的实验结果
- DOI:
10.1109/58.105248 - 发表时间:
1990 - 期刊:
- 影响因子:0
- 作者:
Gregg E. Trahey;Danhua Zhao;John;Miglin;Stephen W. Smith - 通讯作者:
Stephen W. Smith
Gregg E. Trahey的其他文献
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{{ truncateString('Gregg E. Trahey', 18)}}的其他基金
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- 批准号:
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- 资助金额:
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- 批准号:
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