Acoustic Radiation Force Impulse (ARFI) Imaging of Cardiac Tissue
心脏组织的声辐射力脉冲 (ARFI) 成像
基本信息
- 批准号:8241921
- 负责人:
- 金额:$ 60.42万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2009
- 资助国家:美国
- 起止时间:2009-05-15 至 2014-03-31
- 项目状态:已结题
- 来源:
- 关键词:AcousticsAdultAnimal ModelAnimalsAnisotropyCanis familiarisCardiacCardiac ablationCardiologyChildhoodCicatrixClinical ResearchDataDevelopmentDiagnosisDiagnosticDiastolic heart failureEarly DiagnosisEchocardiographyFiberGraft RejectionHeartHeart DiseasesHeart TransplantationHeart failureHumanImageImaging TechniquesInfarctionLabelLesionMeasurementMeasuresMechanicsMethodsMetricModalityModelingMotionMyocardialMyocardial ContractionMyocardial IschemiaMyocardial tissuePhysiologic pulsePhysiologicalPropertyRadiationResolutionRoleSeveritiesStimulusTechniquesTestingTimeTissuesTransplant RecipientsTransplantationUltrasonicsUltrasonographyVariantabstractingcomputerized data processingflexibilityheart functionimage processingimaging modalityimprovedin vivoinstrumentationnovelpressureresponsesuccesstooltwo-dimensional
项目摘要
Abstract
Nearly every form of cardiac disease involves changes to the myocardial stiffness.
Current clinically-viable measurement techniques to assess myocardial stiffness are ei-
ther invasive and/or involve image-derived metrics. We propose the use of a new imaging
method, called Acoustic Radiation Force Impulse (ARFI) imaging, in measuring the me-
chanical properties of myocardial tissue. The technique employs ultrasonic radiation force
to displace tissue. Conventional ultrasound is then used to observe the response of the
tissue to the force. We present preliminary data showing the success of this technique in
imaging the changes in stiffness that occur under normal myocardial function. We pro-
pose to further develop the ARFI imaging technique and then investigate the use of ARFI
imaging in detecting abnormal heart function using animal models. In addition, we pro-
pose human clinical studies with pediatric cardiac transplant patients. These studies will
evaluate the potential of ARFI imaging to provide early detection of transplant rejection,
in grading the severity of heart failure, and in distinguishing between systolic and diastolic
heart failure.
摘要
几乎每一种形式的心脏病都涉及心肌硬度的变化。
目前临床上可行的测量技术,以评估心肌硬度是ei-
其他侵入性的和/或涉及图像衍生的度量。我们建议使用一种新的成像技术
声辐射力脉冲(ARFI)成像方法,在测量的ME,
心肌组织的力学性质。该技术利用超声辐射力
来置换组织。然后使用常规超声来观察
组织的力量。我们目前的初步数据显示,这种技术的成功,
成像正常心肌功能下发生的硬度变化。我们支持-
提出进一步发展ARFI成像技术,然后研究ARFI的使用
成像检测异常心脏功能使用动物模型。此外,我们支持-
对儿童心脏移植患者进行人体临床研究。这些研究将
评估ARFI成像提供移植排斥反应早期检测的潜力,
心力衰竭的严重程度分级,以及区分收缩期和舒张期
心衰
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Gregg E. Trahey其他文献
Off-axis scatterer filters for improved aberration measurements
离轴散射滤光片可改善像差测量
- DOI:
- 发表时间:
2003 - 期刊:
- 影响因子:0
- 作者:
Jeremy J. Dahl;Gregg E. Trahey - 通讯作者:
Gregg E. Trahey
Potential and limitations of angle-independent flow detection algorithms using radio-frequency and detected echo signals.
使用射频和检测到的回波信号的与角度无关的流量检测算法的潜力和局限性。
- DOI:
10.1016/0161-7346(91)90075-s - 发表时间:
1991 - 期刊:
- 影响因子:2.3
- 作者:
B. S. Ramamurthy;Gregg E. Trahey - 通讯作者:
Gregg E. Trahey
Phase Aberration Correction Using Echo Signals from Moving Targets I: Description and Theory
使用来自移动目标的回波信号进行相位像差校正 I:描述和理论
- DOI:
- 发表时间:
1992 - 期刊:
- 影响因子:0
- 作者:
D. Zhao;L. Bohs;Gregg E. Trahey - 通讯作者:
Gregg E. Trahey
Phased array ultrasound imaging through planar tissue layers.
通过平面组织层进行相控阵超声成像。
- DOI:
- 发表时间:
1986 - 期刊:
- 影响因子:2.9
- 作者:
Stephen W. Smith;Stephen W. Smith;Gregg E. Trahey;O. Ramm - 通讯作者:
O. Ramm
Experimental results with a real-time adaptive ultrasonic imaging system for viewing through distorting media
用于透过扭曲介质观察的实时自适应超声成像系统的实验结果
- DOI:
10.1109/58.105248 - 发表时间:
1990 - 期刊:
- 影响因子:0
- 作者:
Gregg E. Trahey;Danhua Zhao;John;Miglin;Stephen W. Smith - 通讯作者:
Stephen W. Smith
Gregg E. Trahey的其他文献
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{{ truncateString('Gregg E. Trahey', 18)}}的其他基金
A Patient-Adaptive, High MI Abdominal Scanner
患者适应性高 MI 腹部扫描仪
- 批准号:
10162585 - 财政年份:2018
- 资助金额:
$ 60.42万 - 项目类别:
A Patient-Adaptive, High MI Abdominal Scanner
患者适应性高 MI 腹部扫描仪
- 批准号:
9924596 - 财政年份:2018
- 资助金额:
$ 60.42万 - 项目类别:
A Patient-Adaptive, High MI Abdominal Scanner
患者适应性高 MI 腹部扫描仪
- 批准号:
9753236 - 财政年份:2018
- 资助金额:
$ 60.42万 - 项目类别:
BME 334 - RADIOLOGY IN PRACTICE (GRADUATE COURSE)
BME 334 - 放射学实践(研究生课程)
- 批准号:
8171576 - 财政年份:2010
- 资助金额:
$ 60.42万 - 项目类别:
BME 334 - RADIOLOGY IN PRACTICE (GRADUATE)
BME 334 - 放射学实践(研究生)
- 批准号:
7956906 - 财政年份:2009
- 资助金额:
$ 60.42万 - 项目类别:
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