Acoustic Radiation Force Impulse (ARFI) Imaging of Cardiac Tissue

心脏组织的声辐射力脉冲 (ARFI) 成像

• 批准号: 8241921
• 负责人: Gregg E. Trahey
• 金额: $ 60.42万
• 依托单位: DUKE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-05-15 至 2014-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8241921
• 关键词: Acoustics; Adult; Animal Model; Animals; Anisotropy; Canis familiaris; Cardiac; Cardiac ablation; Cardiology; Childhood; Cicatrix; Clinical Research; Data; Development; Diagnosis; Diagnostic; Diastolic heart failure; Early Diagnosis; Echocardiography; Fiber; Graft Rejection; Heart; Heart Diseases; Heart Transplantation; Heart failure; Human; Image; Imaging Techniques; Infarction; Label; Lesion; Measurement; Measures; Mechanics; Methods; Metric; Modality; Modeling; Motion; Myocardial; Myocardial Contraction; Myocardial Ischemia; Myocardial tissue; Physiologic pulse; Physiological; Property; Radiation; Resolution; Role; Severities; Stimulus; Techniques; Testing; Time; Tissues; Transplant Recipients; Transplantation; Ultrasonics; Ultrasonography; Variant; abstracting; computerized data processing; flexibility; heart function; image processing; imaging modality; improved; in vivo; instrumentation; novel; pressure; response; success; tool; two-dimensional

Abstract Nearly every form of cardiac disease involves changes to the myocardial stiffness. Current clinically-viable measurement techniques to assess myocardial stiffness are ei- ther invasive and/or involve image-derived metrics. We propose the use of a new imaging method, called Acoustic Radiation Force Impulse (ARFI) imaging, in measuring the me- chanical properties of myocardial tissue. The technique employs ultrasonic radiation force to displace tissue. Conventional ultrasound is then used to observe the response of the tissue to the force. We present preliminary data showing the success of this technique in imaging the changes in stiffness that occur under normal myocardial function. We pro- pose to further develop the ARFI imaging technique and then investigate the use of ARFI imaging in detecting abnormal heart function using animal models. In addition, we pro- pose human clinical studies with pediatric cardiac transplant patients. These studies will evaluate the potential of ARFI imaging to provide early detection of transplant rejection, in grading the severity of heart failure, and in distinguishing between systolic and diastolic heart failure.

抽象的 几乎每种形式的心脏疾病都涉及心肌刚度的变化。 当前评估心肌僵硬度的临床可行测量技术是EI 其中侵入性和/或涉及图像衍生的指标。我们建议使用新成像 方法称为声辐射力脉冲（ARFI）成像，用于测量ME- 心肌组织的chanical特性。该技术采用超声辐射力 置换组织。然后，使用常规超声来观察 组织到力。我们提供了初步数据，显示了此技术在 成像正常心肌功能下发生的刚度的变化。我们支持 姿势以进一步开发ARFI成像技术，然后研究ARFI的使用 使用动物模型检测异常心脏功能时进行成像。此外，我们支持 与小儿心脏移植患者一起构成人类临床研究。这些研究会 评估ARFI成像的潜力，以提供移植排斥的早期检测， 在评估心力衰竭的严重程度，并区分收缩压和舒张期 心脏衰竭。