Acoustic Radiation Force Impulse (ARFI) Imaging of Cardiac Tissue

心脏组织的声辐射力脉冲 (ARFI) 成像

• 批准号: 8241921
• 负责人: Gregg E. Trahey
• 金额: $ 60.42万
• 依托单位: DUKE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-05-15 至 2014-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8241921
• 关键词: Acoustics; Adult; Animal Model; Animals; Anisotropy; Canis familiaris; Cardiac; Cardiac ablation; Cardiology; Childhood; Cicatrix; Clinical Research; Data; Development; Diagnosis; Diagnostic; Diastolic heart failure; Early Diagnosis; Echocardiography; Fiber; Graft Rejection; Heart; Heart Diseases; Heart Transplantation; Heart failure; Human; Image; Imaging Techniques; Infarction; Label; Lesion; Measurement; Measures; Mechanics; Methods; Metric; Modality; Modeling; Motion; Myocardial; Myocardial Contraction; Myocardial Ischemia; Myocardial tissue; Physiologic pulse; Physiological; Property; Radiation; Resolution; Role; Severities; Stimulus; Techniques; Testing; Time; Tissues; Transplant Recipients; Transplantation; Ultrasonics; Ultrasonography; Variant; abstracting; computerized data processing; flexibility; heart function; image processing; imaging modality; improved; in vivo; instrumentation; novel; pressure; response; success; tool; two-dimensional

Abstract Nearly every form of cardiac disease involves changes to the myocardial stiffness. Current clinically-viable measurement techniques to assess myocardial stiffness are ei- ther invasive and/or involve image-derived metrics. We propose the use of a new imaging method, called Acoustic Radiation Force Impulse (ARFI) imaging, in measuring the me- chanical properties of myocardial tissue. The technique employs ultrasonic radiation force to displace tissue. Conventional ultrasound is then used to observe the response of the tissue to the force. We present preliminary data showing the success of this technique in imaging the changes in stiffness that occur under normal myocardial function. We pro- pose to further develop the ARFI imaging technique and then investigate the use of ARFI imaging in detecting abnormal heart function using animal models. In addition, we pro- pose human clinical studies with pediatric cardiac transplant patients. These studies will evaluate the potential of ARFI imaging to provide early detection of transplant rejection, in grading the severity of heart failure, and in distinguishing between systolic and diastolic heart failure.

摘要 几乎每一种形式的心脏病都涉及心肌硬度的变化。 目前临床上可行的测量技术，以评估心肌硬度是ei- 其他侵入性的和/或涉及图像衍生的度量。我们建议使用一种新的成像技术 声辐射力脉冲（ARFI）成像方法，在测量的ME， 心肌组织的力学性质。该技术利用超声辐射力 来置换组织。然后使用常规超声来观察 组织的力量。我们目前的初步数据显示，这种技术的成功， 成像正常心肌功能下发生的硬度变化。我们支持- 提出进一步发展ARFI成像技术，然后研究ARFI的使用 成像检测异常心脏功能使用动物模型。此外，我们支持- 对儿童心脏移植患者进行人体临床研究。这些研究将 评估ARFI成像提供移植排斥反应早期检测的潜力， 心力衰竭的严重程度分级，以及区分收缩期和舒张期 心衰