Coherence-Based Fetal Ultrasonic Imaging

基于相干性的胎儿超声成像

• 批准号: 9912152
• 负责人: Gregg E. Trahey
• 金额: $ 35.56万
• 依托单位: DUKE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-07-01 至 2022-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9912152
• 关键词: Abdomen; Age; Aneuploidy; Body mass index; Cesarean section; Characteristics; Clinical; Clinical Research; Clinical Trials; Congenital Abnormality; Custom; Developed Countries; Developing Countries; Development; Diagnostic; Diagnostic Imaging; Environment; Fetal Monitoring; Fetal Structures; Fetal Viability; Fetal health; Fetus; First Pregnancy Trimester; Gestational Age; Gestational Diabetes; Goals; Growth and Development function; Health; Image; Incidence; Infant; Infection; Lead; Location; Maternal Health; Measures; Methods; Monitor; Morbid Obesity; Morbidity - disease rate; Morphologic artifacts; Mothers; Multiple Pregnancy; Noise; Obesity; Operative Surgical Procedures; Ovary; Overweight; Pathology; Patient imaging; Patients; Pelvis; Performance; Physicians; Placenta; Population Group; Pre-Eclampsia; Pregnancy; Pregnancy Complications; Research; Retrospective Studies; Role; Scanning; Second Pregnancy Trimester; Signal Transduction; Source; Structure; Sum; System; Testing; Time; Ultrasonics; Ultrasonography; United States; Uterus; Visualization; Weight; Woman; age group; base; design; fetal; image processing; imaging capabilities; imaging modality; imaging study; imaging system; improved; maternal obesity; maternal outcome; men; mortality; novel; preference; quantitative imaging; real-time images; reproductive; simulation; stillbirth; theories; unnecessary treatment

Abstract Ultrasonic imaging is widely used to monitor fetal growth and development during the first and second trimester, and multiple studies document the resultant positive impacts on fetal and maternal outcomes. However, current methods fail to provide adequate visualization of key structures in many patients, and alternative imaging modes are rarely available to these patients. We have developed novel ultrasonic beamforming methods that, instead of imaging echo brightness, display the spatial coherence of backscattered echoes. These methods, in simulation, phantom, and clinical studies, show markedly improved image quality over conventional ultrasonic images, especially in difficult-to-image patients. We propose to construct a real-time coherence imaging system on an advanced, commercially available diagnostic scanner. We will extend our theory of coherence imaging to 1.5D and 2D arrays and incorporate these arrays into our real-time imaging system. Clinical studies are proposed to assess the role of coherence imaging in key fetal diagnostic tasks in first trimester and second trimester scans. Quantitative image quality metrics and observer studies are proposed to compare B-mode and coherence images with an emphasis on difficult-to-image patients for whom current imaging methods fail. Related studies will measure the contribution of various sources of image degradation in fetal scans and compare image artifacts observed in conventional and coherence-based ultrasonic images. If successful, the proposed research could lead to a new class of ultrasonic beamforming methods that operate in imaging environments in which current methods fail.

抽象的 超声成像被广泛用于监测第一和第二的胎儿生长和发育 妊娠中期和多项研究记录了对胎儿和孕产妇结局的积极影响。 但是，当前方法无法提供许多患者的关键结构的足够可视化，并且 这些患者很少获得替代成像模式。我们已经开发了新颖的超声波 波束形成的方法，而不是对亮度的成像，而是显示反向散射的空间连贯性 回声。这些方法在模拟，幻影和临床研究中显示出明显改善的图像质量 在传统的超声图像上，尤其是在难以形象的患者中。 我们建议在高级，可商购的上构建实时连贯成像系统 诊断扫描仪。我们将将连贯成像理论扩展到1.5D和2D阵列，并结合 这些阵列进入我们的实时成像系统。 提出了临床研究来评估连贯成像在首次关键胎儿诊断任务中的作用 孕期和妊娠中期扫描。提出了定量图像质量指标和观察者研究 比较B模式和相干图像，并强调难以形象的患者 成像方法失败。相关研究将衡量各种图像降解来源的贡献 胎儿扫描并比较在常规和基于相干的超声图像中观察到的图像伪影。如果 成功的研究可能会导致一类新的超声波束成形方法 在当前方法失败的成像环境中。