OXYTOCIN, VASOPRESSIN AND DEVELOPMENT OF SOCIAL BEHAVIOR

催产素、加压素和社会行为的发展

• 批准号: 2861569
• 负责人: JAMES Timothy WINSLOW
• 金额: $ 23.51万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-04-10 至 2004-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2861569
• 关键词: Macaca mulatta; arginine vasopressin; behavior test; behavioral /social science research tag; brain mapping; chronic disease /disorder; cognition disorders; disease /disorder model; gene expression; hormone receptor; hormone regulation /control mechanism; inhibitor /antagonist; neural information processing; neural transmission; neuropeptides; neuropharmacology; oxytocin; postmortem; psychological reinforcement; social behavior; social behavior disorders; vasopressins

Several recent studies have demonstrated that central oxytocin and vasopressin pathways are important for species typical social behaviors in rodents. This proposal extends this work to non-human primates by investigating oxytocin and vasopressin in both normal and socially abnormal rhesus monkeys. Proposed studies will characterize the social and cognitive deficits in these monkeys, investigate the influence of centrally administered agonists and antagonists, and in post-mortem studies, assess oxytocin and vasopressin function with cellular and molecular techniques. As many of the behavioral deficits in these socially abnormal monkeys resemble the core features of autism and the deficit syndrome of schizophrenia, and reactive attachment disorder, the results from the proposed studies may provide important insights about the pathophysiology and novel medications for these treatment-refractory syndromes.

最近的几项研究表明，中枢催产素和