CENTRAL DETERMINANTS OF IMPULSIVE BEHAVIOR BY JUVENILE MONKEYS

幼猴冲动行为的主要决定因素

• 批准号: 6288141
• 负责人: JAMES Timothy WINSLOW
• 金额: $ 8.4万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-05-01 至 2000-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6288141
• 关键词: Mammalia; behavioral /social science research tag; cognition; nervous system; psychology

Recent studies in rhesus monkeys have demonstrated an association of early developmental stress and decreased plasma measures of serotonin with increased incidence of maladaptive behaviors including aggression, poor impulse control and increased levels of alcohol self-administration. Similar relationships between plasma serotonin and maladaptive behaviors have also been described in humans. The objective of these experiments is to examine the potential role of reduced brain serotonin levels in the development of impulsive behavioral patterns in juvenile rhesus monkeys. We compare juvenile monkeys reared in peer groups with mother reared monkeys who are either intact or have been depleted of brain serotonin following administration of neurotoxic doses of MDMA. Initial comparisons focus on interactions in structured play groups, and performance in a computerized battery of cognitive tasks. Cognitive testing examines memory, attention, and executive function, as well as tasks designed to assess social cognition. Subsequent studies will examine the interaction of decreased central serotonin with the effects of acute alcohol administration, and the incidence of excessive alcohol self-administration in a free-choice ethanol self-administration paradigm. In the last phase of the study we will examine the potential role of brain vasopressinergic neural substrates in the behavioral differences associated with rearing and serotonin. FUNDING URC / Emory University $30,000 4/01/98 - 4/01/99 PUBLICATIONS None P51RR00165-38 1/1/98 - 12/31/98 Yerkes Regional Primate Research Center

最近在恒河猴的研究表明 早期发育应力和血浆测量的减少 5-羟色胺，适应不良行为的发生率增加了 侵略性，冲动控制不力和酒精水平增加 自我管理。 血浆5-羟色胺之间的类似关系 人类也描述了不良适应行为。 这 这些实验的目的是检查 在脉冲发展中降低了脑5-羟色胺水平 少年恒河猴的行为模式。 我们比较少年 猴子与母亲饲养的猴子一起饲养 完整或已耗尽了脑血清素之后 MDMA的神经毒性剂量的给药。 最初的比较焦点 关于结构化游戏组的互动，以及 认知任务的计算机电池。 认知测试检查 记忆，注意力和执行功能以及设计的任务 评估社会认知。 随后的研究将检查 降低中央5-羟色胺与急性影响的相互作用 酒精管理和过度酒精的发病率 在自由选择的乙醇自我管理中的自我管理 范例。 在研究的最后阶段，我们将研究 脑血管加压素能神经底物的潜在作用 与饲养和5-羟色胺相关的行为差异。 资金 URC/埃默里大学$ 30,000 4/01/98-4/01/99出版物无 P51RR00165-38 1/1/98-12/31/98 Yerkes区域灵长类动物研究 中心