CENTRAL DETERMINANTS OF IMPULSIVE BEHAVIOR BY JUVENILE MONKEYS

幼猴冲动行为的主要决定因素

• 批准号: 6277509
• 负责人: JAMES Timothy WINSLOW
• 金额: $ 3.54万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-05-01 至 1999-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6277509
• 关键词: Mammalia; Primates; cognition; nervous system; psychology

Recent studies in rhesus monkeys have demonstrated an association of early developmental stress and decreased plasma measures of serotonin with increased incidence of maladaptive behaviors including aggression, poor impulse control and increased levels of alcohol self-administration. Similar relationships between plasma serotonin and maladaptive behaviors have also been described in humans. The objective of these experiments is to examine the potential role of reduced brain serotonin levels in the development of impulsive behavioral patterns in juvenile rhesus monkeys. We compare juvenile monkeys reared in peer groups with mother reared monkeys who are either intact or have been depleted of brain serotonin following administration of neurotoxic doses of MDMA. Initial comparisons focus on interactions in structured play groups, and performance in a computerized battery of cognitive tasks. Cognitive testing examines memory, attention, and executive function, as well as tasks designed to assess social cognition. Subsequent studies will examine the interaction of decreased central serotonin with the effects of acute alcohol administration, and the incidence of excessive alcohol self-administration in a free-choice ethanol self-administration paradigm. In the last phase of the study we will examine the potential role of brain vasopressinergic neural substrates in the behavioral differences associated with rearing and serotonin.

最近对恒河猴的研究表明， 早期发育压力和血浆中 5-羟色胺与适应不良行为的发生率增加，包括 攻击性，冲动控制不良和酒精含量增加 自我管理。 血浆5-羟色胺与 和适应不良的行为也在人类中被描述过。 的 这些实验的目的是研究 降低大脑中5-羟色胺的水平， 幼年恒河猴的行为模式。 我们比较青少年 猴子在同伴群体中饲养，母亲饲养的猴子 无论是完整的，还是已经耗尽了大脑血清素， 神经毒性剂量的MDMA。 初步比较重点 在有组织的游戏小组中的互动，以及在一个 计算机化认知任务组合。 认知测试检查 记忆力、注意力和执行功能，以及设计的任务 来评估社会认知。 随后的研究将审查 中枢5-羟色胺减少与急性 酒精管理和过量酒精的发生率 自由选择乙醇自我给药中的自我给药 范例 在研究的最后阶段，我们将研究 脑血管加压素能神经基质在脑缺血中的潜在作用 与养育和血清素相关的行为差异。