OXYTOCIN, VASOPRESSIN AND DEVELOPMENT OF SOCIAL BEHAVIOR

最近的几项研究表明，中枢催产素和 加压素途径对物种典型的社会行为很重要 在啮齿动物身上。这项提议通过以下方式将这项工作扩展到非人类灵长类动物 正常人群和社交人群中催产素和加压素的研究 不正常的恒河猴。拟议的研究将描述社会 以及这些猴子的认知缺陷，调查 中央给药的激动剂和拮抗剂，以及在尸检中 研究，评估催产素和加压素的功能 分子技术。因为这些人的许多行为缺陷 社交异常的猴子与自闭症的核心特征相似 精神分裂症的缺陷综合征和反应性依恋障碍 拟议研究的结果可能会为以下方面提供重要的见解 难治性疾病的病理生理机制及新药治疗 综合症。

Several recent studies have demonstrated that central oxytocin and vasopressin pathways are important for species typical social behaviors in rodents. This proposal extends this work to non-human primates by investigating oxytocin and vasopressin in both normal and socially abnormal rhesus monkeys. Proposed studies will characterize the social and cognitive deficits in these monkeys, investigate the influence of centrally administered agonists and antagonists, and in post-mortem studies, assess oxytocin and vasopressin function with cellular and molecular techniques. As many of the behavioral deficits in these socially abnormal monkeys resemble the core features of autism and the deficit syndrome of schizophrenia, and reactive attachment disorder, the results from the proposed studies may provide important insights about the pathophysiology and novel medications for these treatment-refractory syndromes.