OXYTOCIN, VASOPRESSIN AND DEVELOPMENT OF SOCIAL BEHAVIOR

最近的几项研究表明，中枢催产素和 加压素通路对于物种典型的社会行为是重要的 在啮齿类动物中。 这项提议将这项工作扩展到非人类灵长类动物， 研究正常人和社交人群中的催产素和加压素 异常的恒河猴 拟议的研究将描述社会 和认知缺陷，研究 中枢给药的激动剂和拮抗剂， 研究，评估催产素和加压素的功能与细胞和 分子技术 这些人的行为缺陷 社交异常的猴子与自闭症的核心特征相似， 精神分裂症缺陷综合征和反应性依恋障碍， 拟议研究的结果可能会提供重要的见解， 这些难治性的病理生理学和新的药物治疗 综合征

Several recent studies have demonstrated that central oxytocin and vasopressin pathways are important for species typical social behaviors in rodents. This proposal extends this work to non-human primates by investigating oxytocin and vasopressin in both normal and socially abnormal rhesus monkeys. Proposed studies will characterize the social and cognitive deficits in these monkeys, investigate the influence of centrally administered agonists and antagonists, and in post-mortem studies, assess oxytocin and vasopressin function with cellular and molecular techniques. As many of the behavioral deficits in these socially abnormal monkeys resemble the core features of autism and the deficit syndrome of schizophrenia, and reactive attachment disorder, the results from the proposed studies may provide important insights about the pathophysiology and novel medications for these treatment-refractory syndromes.