CHEMISTRY SUPPORT FOR ENVIRONMENTAL TOXICOLOGY PROGRAM

环境毒理学计划的化学支持

• 批准号: 2767284
• 负责人: EVELYN A MURRILL
• 金额: --
• 依托单位: MIDWEST RESEARCH INSTITUTE
• 依托单位国家: 美国
• 财政年份: 1995
• 资助国家: 美国
• 起止时间: 1995-09-30 至 2000-11-15
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2767284
• 关键词: analytical method; animal care; bioassay; carcinogen testing; chemical standardization; computer data analysis; drug design /synthesis /production; environmental toxicology; health science research; immunotoxicity; mutagen testing; neurotoxins; reproductive system; toxicant screening

This contract is for the recompetition of chemistry support services for the National Toxicology Program (NTP) Environmental Toxicology Branch (ETB). The ETB has responsibility for the Two-Year Bioassay, Short-Term Toxicology, Developmental Toxicology, Reproductive, Developmental and General Toxicology Screen, Reproductive Assessment by Continuous Breeding Immunology, and Neurotoxicology programs for the NTP, and the AIDS Therapeutics program. Chemistry support services will be needed for each program, and for program related in-house research efforts. The ETB conducts applied research with various chemicals and other potentially hazardous agents to improve test protocols, to develop new tests, and to improve interpretation of test results for the two-year bioassay program, short term toxicology program and toxicity to the reproductive, immune, and neurological systems. To insure that the species under study are exposed to the prescribed chemicals and at the specified dose concentrations, proper chemistry support is required. The necessary support includes chemical characterization, dose preparation, dose concentration verification, and internal dose determination. These contracts will provide chemistry support services which are to include bulk chemical procurement, bulk chemical handling, preliminary chemical studies, bulk chemical comprehensive analyses, limited bulk chemical analyses, bulk chemical inhalation analyses, dose formulation developmental studies, dose preparation analysis, dose analysis, referee analysis, dose vehicle analysis, chemical storage, shipment, hazardous waste disposal, biological sample method development, toxicokinetic study, biological sample analysis, and prestart toxicokinetic study. Additional requirements include providing a quality program, safety and health, animal care, disposal of wastes, computerized project management system, coordination with other NTP contractors, microfiching data, and providing continuity of services.

该合同是为了重新补充化学支持服务 国家毒理学计划（NTP）环境毒理学分支 （ETB）。 ETB对两年生物测定的短期负责 毒理学，发育毒理学，生殖，发育和 通用毒理学筛查，连续的生殖评估 NTP的育种免疫学和神经毒理学计划， AIDS治疗计划。化学支持服务将需要 每个程序，以及有关计划相关的内部研究工作。 ETB 对各种化学物质和其他潜在的应用进行应用的研究 危险代理改善测试方案，开发新测试和 改善对两年生物测定的测试结果的解释 计划，短期毒理学计划和对生殖的毒性， 免疫和神经系统。确保正在研究的物种 暴露于规定的化学品和指定剂量 需要浓度，需要适当的化学支持。必要的 支持包括化学表征，剂量制备，剂量 浓度验证和内剂量测定。 这些合同将提供化学支持服务 包括散装化学采购，散装化学处理，初步 化学研究，批量化学综合分析，大量有限 化学分析，大量化学吸入分析，剂量制剂 发展研究，剂量准备分析，剂量分析，裁判 分析，剂量车辆分析，化学存储，发货，危险 废物处理，生物样品方法开发，有毒动力学 研究，生物样品分析和PRESTART有毒动力学研究。 其他要求包括提供质量计划，安全性和 健康，动物护理，废物处理，计算机化项目管理 系统，与其他NTP承包商的协调，微腓数据和 提供服务的连续性。