CHEMISTRY SUPPORT FOR ENVIRONMENTAL TOXICOLOGY PROGRAM

环境毒理学计划的化学支持

• 批准号: 2659462
• 负责人: EVELYN A MURRILL
• 金额: --
• 依托单位: MIDWEST RESEARCH INSTITUTE
• 依托单位国家: 美国
• 财政年份: 1995
• 资助国家: 美国
• 起止时间: 1995-09-30 至 2000-11-15
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2659462
• 关键词: analytical method; animal care; bioassay; carcinogen testing; chemical standardization; computer data analysis; drug design /synthesis /production; environmental toxicology; health science research; immunotoxicity; mutagen testing; neurotoxins; reproductive system; toxicant screening

This contract is for the recompetition of chemistry support services for the National Toxicology Program (NTP) Environmental Toxicology Branch (ETB). The ETB has responsibility for the Two-Year Bioassay, Short-Term Toxicology, Developmental Toxicology, Reproductive, Developmental and General Toxicology Screen, Reproductive Assessment by Continuous Breeding Immunology, and Neurotoxicology programs for the NTP, and the AIDS Therapeutics program. Chemistry support services will be needed for each program, and for program related in-house research efforts. The ETB conducts applied research with various chemicals and other potentially hazardous agents to improve test protocols, to develop new tests, and to improve interpretation of test results for the two-year bioassay program, short term toxicology program and toxicity to the reproductive, immune, and neurological systems. To insure that the species under study are exposed to the prescribed chemicals and at the specified dose concentrations, proper chemistry support is required. The necessary support includes chemical characterization, dose preparation, dose concentration verification, and internal dose determination. These contracts will provide chemistry support services which are to include bulk chemical procurement, bulk chemical handling, preliminary chemical studies, bulk chemical comprehensive analyses, limited bulk chemical analyses, bulk chemical inhalation analyses, dose formulation developmental studies, dose preparation analysis, dose analysis, referee analysis, dose vehicle analysis, chemical storage, shipment, hazardous waste disposal, biological sample method development, toxicokinetic study, biological sample analysis, and prestart toxicokinetic study. Additional requirements include providing a quality program, safety and health, animal care, disposal of wastes, computerized project management system, coordination with other NTP contractors, microfiching data, and providing continuity of services.

本合同是为化学支持服务的再竞争