CHEMISTRY SUPPORT FOR ENVIRONMENTAL TOXICOLOGY PROGRAM

环境毒理学计划的化学支持

• 批准号: 2310231
• 负责人: EVELYN A MURRILL
• 金额: $ 174.3万
• 依托单位: MIDWEST RESEARCH INSTITUTE
• 依托单位国家: 美国
• 财政年份: 1995
• 资助国家: 美国
• 起止时间: 1995-09-30 至 2000-09-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2310231
• 关键词: CHEMISTRY; SUPPORT; ENVIRONMENTAL; TOXICOLOGY; PROGRAM

This contract is for the recompetition of chemistry support services for the National Toxicology Program (NTP) Environmental Toxicology Branch (ETB). The ETB has responsibility for the Two-Year Bioassay, Short-Term Toxicology, Developmental Toxicology, Reproductive, Developmental and General Toxicology Screen, Reproductive Assessment by Continuous Breeding Immunology, and Neurotoxicology programs for the NTP, and the AIDS Therapeutics program. Chemistry support services will be needed for each program, and for program related in-house research efforts. The ETB conducts applied research with various chemicals and other potentially hazardous agents to improve test protocols, to develop new tests, and to improve interpretation of test results for the two-year bioassay program, short term toxicology program and toxicity to the reproductive, immune, and neurological systems. To insure that the species under study are exposed to the prescribed chemicals and at the specified dose concentrations, proper chemistry support is required. The necessary support includes chemical characterization, dose preparation, dose concentration verification, and internal dose determination. These contracts will provide chemistry support services which are to include bulk chemical procurement, bulk chemical handling, preliminary chemical studies, bulk chemical comprehensive analyses, limited bulk chemical analyses, bulk chemical inhalation analyses, dose formulation developmental studies, dose preparation analysis, dose analysis, referee analysis, dose vehicle analysis, chemical storage, shipment, hazardous waste disposal, biological sample method development, toxicokinetic study, biological sample analysis, and prestart toxicokinetic study. Additional requirements include providing a quality program, safety and health, animal care, disposal of wastes, computerized project management system, coordination with other NTP contractors, microfiching data, and providing continuity of services.

这份合同是为了重新竞争以下化学支持服务 国家毒理学计划(NTP)环境毒理学分会 (ETB)。ETB负责为期两年的短期生物检测 毒理学、发育毒理学、生殖、发育和 常规毒理学筛查、连续生殖评估 NTP的繁殖免疫学和神经毒理学项目，以及 艾滋病治疗计划。将需要化学支持服务 每个项目，以及与项目相关的内部研究工作。经济及社会服务局 进行各种化学品和其他潜在用途的应用研究 危险试剂以改进测试方案，开发新的测试，以及 改善为期两年的生物化验的测试结果解释 计划，短期毒理学计划和生殖毒性， 免疫系统和神经系统。以确保研究中的物种 暴露于订明的化学品并按指定剂量 浓度，需要适当的化学支持。必要的 支持包括化学特性、剂量制备、剂量 浓度验证和内剂量测定。 这些合同将提供化学支持服务，以 包括散装化学品采购、散装化学品装卸、初步 化学研究、散装化学综合分析、有限散装 化学分析、散装化学吸入分析、剂量配方 发育研究，剂量准备分析，剂量分析，参考 分析，剂量车辆分析，化学品储存，运输，危险 废物处理，生物样品方法发展，毒物动力学 研究、生物样品分析和启动前的毒物动力学研究。 其他要求包括提供高质量的计划、安全和 健康、动物护理、废物处理、计算机化项目管理 系统、与其他NTP承包商的协调、缩微数据以及 提供服务的连续性。