CHEMISTRY SUPPORT FOR ENVIRONMENTAL TOXICOLOGY PROGRAM

该合同是为化学支持服务的再竞争， 国家毒理学计划（NTP）环境毒理学分支 （ETB）。ETB负责两年生物测定，短期 毒理学、发育毒理学、生殖、发育和 一般毒理学筛选，生殖评估（连续 繁殖免疫学和神经毒理学项目，以及 艾滋病治疗方案。将需要化学支持服务， 每个项目，以及与项目相关的内部研究工作。述ETB 进行各种化学品和其他潜在的应用研究 有害物质，以改善测试协议，开发新的测试， 改善两年生物测定试验结果的解释 短期毒理学项目和生殖毒性， 免疫和神经系统。为了确保所研究的物种 暴露于规定的化学品和指定剂量 浓度，需要适当的化学支持。必要的 支持包括化学表征、剂量制备、剂量 浓度验证和内部剂量确定。 这些合同将提供化学支持服务， 包括大宗化学品采购、大宗化学品处理、初步 化学研究，散装化学综合分析，有限散装 化学分析、散装化学品吸入分析、给药制剂 发展研究，剂量制备分析，剂量分析，裁判 分析、剂量溶剂分析、化学品储存、运输、危险 废物处理，生物样品方法开发，毒代动力学 研究、生物样品分析和启动前毒代动力学研究。 其他要求包括提供质量计划、安全和 卫生、动物护理、废物处理、计算机化项目管理 系统，与其他NTP承包商的协调，缩微胶片数据，以及 提供服务的连续性。

This contract is for the recompetition of chemistry support services for the National Toxicology Program (NTP) Environmental Toxicology Branch (ETB). The ETB has responsibility for the Two-Year Bioassay, Short-Term Toxicology, Developmental Toxicology, Reproductive, Developmental and General Toxicology Screen, Reproductive Assessment by Continuous Breeding Immunology, and Neurotoxicology programs for the NTP, and the AIDS Therapeutics program. Chemistry support services will be needed for each program, and for program related in-house research efforts. The ETB conducts applied research with various chemicals and other potentially hazardous agents to improve test protocols, to develop new tests, and to improve interpretation of test results for the two-year bioassay program, short term toxicology program and toxicity to the reproductive, immune, and neurological systems. To insure that the species under study are exposed to the prescribed chemicals and at the specified dose concentrations, proper chemistry support is required. The necessary support includes chemical characterization, dose preparation, dose concentration verification, and internal dose determination. These contracts will provide chemistry support services which are to include bulk chemical procurement, bulk chemical handling, preliminary chemical studies, bulk chemical comprehensive analyses, limited bulk chemical analyses, bulk chemical inhalation analyses, dose formulation developmental studies, dose preparation analysis, dose analysis, referee analysis, dose vehicle analysis, chemical storage, shipment, hazardous waste disposal, biological sample method development, toxicokinetic study, biological sample analysis, and prestart toxicokinetic study. Additional requirements include providing a quality program, safety and health, animal care, disposal of wastes, computerized project management system, coordination with other NTP contractors, microfiching data, and providing continuity of services.