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DIAGNOSTIC NEUROACTIVATION PET STUDIES

诊断性神经激活宠物研究

基本信息

批准号：
2890647
负责人：
John R Votaw
金额：
$ 9.96万
依托单位：
EMORY UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
1995
资助国家：
美国
起止时间：
1995-08-01 至 2001-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/2890647
关键词：
bioimaging /biomedical imaging biomedical automation brain disorder diagnosis butanols data collection diagnosis design /evaluation diagnosis quality /standard epilepsy human subject method development nervous system disorder epidemiology neuroanatomy oxygen positron emission tomography radionuclides radiotracer water

项目摘要

Between 0.2-1% of the population is epileptic. Approximately one quarter of epileptics are refractory to medical treatment and most have temporal lobe epilepsy. These patients are candidates for temporal lobectomy. Unfortunately, after surgery, many suffer a loss in naming ability. This is one example where if the sensitivity of a PET activation study were improved so that significant results for a single individual could be attained, management of the patient might be improved. The purpose of this project is to enhance PET activation imaging until this is possible. To date, PET activation studies have been used to form conclusions concerning groups of patients. This work intends to enhance activation studies so that significant conclusions can be drawn on individual patients. This work is an investigation into five areas of the PET activation technique. First, side-by-side tests comparing (15-0)water and (15- 0)butanol will be performed. (15-O)Butanol has been proposed (but not validated) as a potentially superior radiotracer because it is more freely diffusible across the blood brain barrier. The second area is an optimization of the acquisition protocol to maximize the information in a PET study. In this subproject, the relative timing between the task onset and the data acquisition, the duration of the acquisition, and the task presentation will be investigated. Included is an investigation into the effects of habituation. The confrontational naming stimulus task will be used but our intention is to produce a set of general principles for optimizing any activation task. Third, an objective method for identifying activated regions of the brain will be developed. The innovation in the proposed work is to directly manipulate the primary data (2D or 3D sinograms), where the statistical properties are known, to produce images with equal variance in every pixel (Z-images). From the Z-images, the probability that any particular region of the brain has been activated can be obtained. Given an acceptable false positive rate, all significantly activated regions are determined objectively. Fourth, recent PET scanner developments have provided the ability to collect 3D data. With 3D data acquisition, the interplane septa are removed to increase (by an order of magnitude) the overall sensitivity of the scanner but the increase is not uniform across the imaging field of view. Also, the image contrast is reduced because of a greatly increased scatter fraction. The Z-image methods will be used in side-by-side tests of 2D versus 3D PET data acquisition to determine the relative advantages of each. We anticipate that the cumulative improvement from each of these subprojects will produce a PET activation technique that is able to provide significant conclusions concerning individual patients. This work is a proof of principle project. The techniques developed here, specifically for studying epilepsy, are equally applicable to transferring other PET activation research to the clinical setting. Our long term goals are to develop a range of diagnostic activation tests that will allow a physician to treat neuro illnesses based on the neurobiology of their disease rather than relying solely on the presenting symptoms.

0.2-1%的人口患有癫痫。大约四分之一的癫痫患者是难治性的药物治疗，脑叶癫痫这些病人是颞叶切除术的候选者。不幸的是，手术后，许多人失去了命名能力。这是一个例子，如果PET激活研究的灵敏度是改进，以便可以为单个个体提供显著的结果，这样，病人的管理就可以得到改善。这样做的目的项目是增强PET激活成像，直到这是可能的。到迄今为止，PET活化研究已用于形成以下结论：患者群体。这项工作旨在加强活化研究，可以从个体患者身上得出重要的结论。本工作是对PET激活的五个方面的调查法首先，并排测试比较（15-0）水和（15-0）水。 0)将执行丁醇。（15-O）丁醇已被提出（但没有已验证）作为潜在的上级放射性示踪剂，因为它更自由可扩散穿过血脑屏障。第二个领域是优化采集协议，以最大限度地提高 PET研究。在这个子项目中，以及数据采集、采集持续时间和任务介绍将进行调查。其中包括对习惯化的影响。对抗性的命名刺激任务将是但我们的目的是制定一套一般原则，优化任何激活任务。第三，一种客观的识别方法大脑的激活区域会被开发出来的创新建议的工作是直接操作原始数据（2D或3D 正弦图），其中统计特性是已知的，以产生图像在每个像素中具有相等的方差（Z图像）。从Z图像来看，大脑的任何特定区域被激活的概率获得。考虑到可接受的假阳性率，所有这些都显着客观地确定激活区域。四、最近的PET扫描仪发展已经提供了收集3D数据的能力。与3D数据采集时，去除面间隔膜以增加（数量级幅度）扫描仪的整体灵敏度，但增加不是在整个成像视场中是均匀的。此外，图像对比度是由于散射分数大大增加而减少。 Z图像方法将用于2D与3D PET数据的并行测试以确定各自的相对优势。我们预计，每一项措施的累积改善子项目将产生PET激活技术，能够提供关于个别患者的重要结论。这项工作是一个原则项目的证明。这里开发的技术，专门用于研究癫痫，同样适用于转移其他PET 激活研究到临床环境。我们的长期目标是开发一系列诊断激活测试，根据疾病的神经生物学来治疗神经疾病，而不是仅仅依靠症状

项目成果

期刊论文数量（6）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

A confrontational naming task produces congruent increases and decreases in PET and fMRI.

对抗性命名任务会导致 PET 和 fMRI 的一致增加和减少。

DOI：
10.1006/nimg.1999.0471
发表时间：
1999
期刊：
NeuroImage
影响因子：
5.7
作者：
Votaw,JR;Faber,TL;Popp,CA;Henry,TR;Trudeau,JD;Woodard,JL;Mao,H;Hoffman,JM;Song,AW
通讯作者：
Song,AW

Performance evaluation of the Pico-Count flow-through detector for use in cerebral blood flow PET studies.

用于脑血流 PET 研究的 Pico-Count 流通检测器的性能评估。

DOI：
发表时间：
1998
期刊：
Journal of nuclear medicine : official publication, Society of Nuclear Medicine
影响因子：
0
作者：
Votaw,JR;Shulman,SD
通讯作者：
Shulman,SD

Compartmental modeling of 11C-HOMADAM binding to the serotonin transporter in the healthy human brain.

DOI：
10.2967/jnumed.108.054262
发表时间：
2008-12
期刊：
Journal of nuclear medicine : official publication, Society of Nuclear Medicine
影响因子：
0
作者：
Nye JA;Votaw JR;Jarkas N;Purselle D;Camp V;Bremner JD;Kilts CD;Nemeroff CB;Goodman MM
通讯作者：
Goodman MM

Butanol is superior to water for performing positron emission tomography activation studies.

在进行正电子发射断层扫描激活研究方面，丁醇优于水。