Core C: Biostatistics, Modeling, and Data Management

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OVERVIEW The purpose of the Biostatistics, Modeling and Data Management Core (Core C) of the Emory Molecular and Translational Imaging Center (EMTIC) is to provide a comprehensive, multi-disciplinary resource for the design of clinical and basic science experiments, including statistical analysis, image analysis, and summarizing the results. The core has the following overall goal: to provide statistical and imaging protocol consulting and collaboration on the design, conduct, analysis and interpretation of all research studies and cores, and to provide, manage and maintain a high-quality research database that supports the projects and cores while preserving the confidentiality of all subject data. The specific aims are: (1) Provide quantitative image analysis, (2) Coordinate and manage statistical activities in the ICMIC to ensure investigators have ready access to statistical consultation and support. (3) Provide imaging protocol and statistical expertise in the design of experiments and studies, including research proposal development, specifying analysis methods, sample size determination, randomization procedures, and plans for interim reviews and final analysis. (4) Assist with the writing of image analysis and statistical components of manuscripts. (5) Review the integrity and statistical soundness of all studies. (6) Provide image analysis and statistical analysis for all projects using appropriate methodologies, and assist in the interpretation and presentation of results. (7) Interact and collaborate with the Clinical Trials and Translational Research Office in the development of protocols and monitoring and reporting of clinical data. (8) Maintain a computing facility for the purpose of extracting quantitative physiological information from the collected images. (9) Maintain a computing facility with up-todate software for statistical analysis. (10) Provide computer-based tools that facilitate the storage, retrieval, and viewing of the data generated in the proposed research, thereby creating and maintaining a centralized relational database that provides access to common resources and information. (11) Ensure the accuracy of the data maintained in the database by software based data consistency and quality control systems. (12) Organize and maintain the database to maximize accuracy and accessibility; while maintaining strict confidentiality. (13) Provide detailed descriptions of the available populations and resources for current and future investigators. (14) Provide high-quality data entry services.