Biostatistics, Modeling, and Data Management

生物统计学、建模和数据管理

• 批准号: 8135473
• 负责人: John R Votaw
• 金额: $ 8.96万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/8135473
• 关键词: Basic Science; Biometry; Clinical; Clinical Data; Clinical Trials; Collaborations; Computer software; Computers; Confidentiality; Consult; Consultations; Data; Data Analyses; Data Quality; Data Storage and Retrieval; Databases; Development; Ensure; Future; Goals; Image; Image Analysis; Institutes; Kinetics; Malignant Neoplasms; Manuscripts; Measures; Methodology; Methods; Modeling; Molecular; Monitor; Performance; Physiological; Population; Procedures; Protocols documentation; Quality Control; Randomized; Reporting; Research; Research Methodology; Research Personnel; Research Project Grants; Research Proposals; Resources; Retrieval; Sample Size; Services; Specific qualifier value; Statistical Data Interpretation; Statistical Models; System; Translational Research; Writing; base; data management; design; innovation; protocol development; relational database; research study; tool

The purpose of the Biostatistics, Modeling, and Data Management Core (Core C) is to provide a comprehensive, multi-disciplinary resource for the design of all experiments, development of appropriate and innovative statistical methodology, development and application of appropriate kinetic models to intrepret the data, statistical analysis, and summarization of results. The Core has the following overall goals: to provide statistical and modeling consulting and collaboration on the design, conduct, analysis and interpretation of all project research studies and cores, and to provide, manage and maintain a high-quality research database that supports the research projects and cores while preserving the confidentiality of all subject data. The specific aims are to: (1) Coordinate and manage statistical activities to ensure investigators have ready access to statistical consultation and support. (2) Provide statistical expertise in the design of experiments and studies, including research proposal development, analysis methods, sample size determination, randomization procedures, and plans for interim reviews and final analysis. (3) Provide kinetic modeling expertice for all projects using imaging to measure physiologic parameters. (4) Provide data analysis and extraction to obtain the necessary information from project data. (5) Assist with the writing of statistical and modeling components of manuscripts. (6) Review the integrity and statistical soundness of all studies. (7) Maintain a computing facility with up-to-date software for statistical analysis to support all project investigators. (8) Conduct biostatistical methodology research on practical problems arising from performance of the projects. (9) Develop new modeling approaches as necessary to maximize the utility of each investigator's data. (10) Provide computer-based tools that facilitate the storage and retrieval of the data generated in the proposed research, thereby creating and maintaining a centralized relational database that provides access to common resources and information. (11) Ensure the accuracy of the data maintained in the database by software based data consistency and quality control systems. (12) Organize and maintain the database to maximize accuracy and accessibility while maintaining strict confidentiality. (13) Provide detailed descriptions of the available populations and resources for current and future investigators. (14) Provide high-quality data entry services.

生物统计、建模和数据管理核心（核心 C）的目的是提供 用于设计所有实验、开发 适当和创新的统计方法，适当动力学的开发和应用 解释数据、统计分析和结果总结的模型。核心有 遵循总体目标：提供统计和建模咨询以及设计协作， 对所有项目研究和核心进行、分析和解释，并提供、管理 并维护一个高质量的研究数据库，以支持研究项目和核心，同时 保护所有主题数据的机密性。具体目标是：（一）协调管理 开展统计活动，以确保调查人员能够随时获得统计咨询和支持。 (2) 提供实验和研究设计方面的统计专业知识，包括研究提案 开发、分析方法、样本量确定、随机化程序和计划 中期审查和最终分析。 (3) 为所有使用成像的项目提供动力学建模专业知识 测量生理参数。 (4) 提供数据分析和提取，以获得必要的数据 来自项目数据的信息。 (5) 协助编写统计和建模组件 手稿。 (6) 审查所有研究的完整性和统计健全性。 (7) 维持 配备最新统计分析软件的计算设施，可为所有项目研究人员提供支持。 （八）针对绩效中出现的实际问题进行生物统计方法学研究 项目。 (9) 根据需要开发新的建模方法，以最大化每种方法的效用 调查员的数据。 (10) 提供基于计算机的工具，以方便存储和检索 拟议研究中生成的数据，从而创建和维护集中的关系 提供对公共资源和信息的访问的数据库。 (11)保证数据的准确性 数据库中的数据由基于软件的数据一致性和质量控制系统维护。 (12) 组织和维护数据库，以最大限度地提高准确性和可访问性，同时保持严格的 保密性。 (13) 提供当前可用人口和资源的详细描述 和未来的调查员。 （十四）提供优质的数据录入服务。