权益分类	功能权益	普通用户	{{item.name}}会员
{{category.name}}	{{benefitItem.name}}

AUTONOMIC NERVOUS SYSTEM FUNCTIONING IN THE HUMAN FETUS

人类胎儿自主神经系统的功能

基本信息

批准号：
2872836
负责人：
LYNN J GROOME
金额：
$ 10.74万
依托单位：
UNIVERSITY OF SOUTH ALABAMA
依托单位国家：
美国
项目类别：
财政年份：
1995
资助国家：
美国
起止时间：
1995-02-01 至 2000-01-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/2872836
关键词：
auditory stimulus central nervous system developmental neurobiology electrocardiography embryo /fetus heart rate human subject infant human (0-1 year) mammalian embryology newborn human (0-6 weeks) parasympathetic nervous system sympathetic nervous system

项目摘要

A number of developmental disorders in children, including learning disabilities, can be traced to deficits in attention and abnormalities in autonomic nervous system (ANS) functioning. A vagally-mediated decrease in heart rate is used as a marker of attention in infants, and an association between prestimulus respiratory sinus arrhythmia (RSA) and the magnitude of the heart rate deceleration has been demonstrated. Evaluation of ANS functioning and information processing capabilities are particularly well- suited for assessing central nervous system (CNS) status in utero: the ANS can be examined in human fetuses noninvasively using spectral decomposition techniques, and human fetuses are capable of displaying a heart rate deceleratory response to certain acoustic stimuli. After identifying acoustic parameters which consistently elicit a heart rate deceleration in normal human term fetuses, we will examine the relationship between prestimulus RSA and the magnitude of the cardiac deceleratory response and determine if there is a decrease in respiratory frequency and heart rate variability (HRV) concomitant with the heart rate deceleration. Furthermore, we will determine if fetuses categorized as sympathetic-dominant exhibit a different type of cardiac response to low- intensity acoustic stimuli than fetuses categorized as parasympathetic- dominant and whether these characteristics are stable over time. Special emphasis will be placed on identifying parameters which are capable of distinguishing growth-restricted fetuses and fetuses with CNS structural anomalies from normal fetuses. An important aspect of the proposed study plan is that subjects examined as fetuses will be examined again as neonates and will be followed prospectively to two years of age. The fetal electrocardiogram will be captured noninvasively using standard cardiac electrodes positioned on the mother's abdomen. Adaptive signal processing methodology will be used to extract fetal R-waves from the raw data. Sympathetic-parasympathetic balance will be evaluated by applying spectral decomposition techniques to the analysis of fetal and neonatal HRV data. The heart rate response to low-intensity acoustic stimuli will be related to ANS functioning in both fetuses and neonates. We believe that differences in intrinsic ANS activity and cardiac responsivity may ultimately help to identify the fetus at-risk for neurobehavioral abnormalities and hence facilitate the implementation of appropriate intervention protocols early in the course of development.

儿童的一些发育障碍，包括学习残疾，可以追溯到注意力不足和自主神经系统(ANS)功能。一种由迷宫调节的减少心率被用作婴儿注意力的标志，并与刺激前呼吸性窦性心律失常与心率变异性的关系已经证实了心率减速的可能性。对ANS的评估运作和信息处理能力尤其出色- 适合于评估子宫内中枢神经系统(CNS)状态的ANS 可利用光谱技术在人类胎儿体内进行无创检测分解技术，人类胎儿能够显示出心率对某些声音刺激的减速反应。之后识别持续引起心率的声学参数正常足月胎儿的减速，我们将检查刺激前RSA与心脏大小的关系减速反应，并确定呼吸是否减少频率和心率变异性(HRV)伴随着心率减速。此外，我们将确定胎儿是否被归类为交感神经优势型表现出一种不同类型的心脏反应比被归类为副交感神经的胎儿更强烈的声刺激- 以及这些特征是否随着时间的推移而稳定。特价重点将放在确定能够中枢神经系统结构障碍胎儿与生长受限胎儿的鉴别正常胎儿的异常。拟议研究的一个重要方面计划是，被检查为胎儿的受试者将再次接受检查新生儿，并将前瞻性地跟踪到两岁。这个胎儿心电图将使用标准的无创采集放置在母亲腹部的心脏电极。自适应信号将使用处理方法从原始数据中提取胎儿R波数据。交感-副交感神经平衡将通过应用光谱分解技术在胎儿和新生儿分析中的应用心率变异性数据。心率对低强度声刺激的反应将与ANS在胎儿和新生儿中的功能有关。我们相信固有的ANS活性和心脏反应性的差异可能最终帮助确定神经行为的高危胎儿异常情况，从而便利执行适当的在开发过程中的早期干预方案。