STUDY CORONARY HEART DISEASE RISK IN YOUNG ADULTS

研究年轻人的冠心病风险

• 批准号: 6154506
• 负责人: PAMELA J SCHREINER
• 金额: $ 64.32万
• 依托单位: UNIVERSITY OF MINNESOTA
• 依托单位国家: 美国
• 财政年份: 1983
• 资助国家: 美国
• 起止时间: 1983-12-30 至 2003-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6154506
• 关键词: age difference; blood glucose; blood pressure; body physical characteristic; cardiovascular disorder epidemiology; cardiovascular stress test; clinical research; cooperative study; coronary disorder; diabetes mellitus; diet; disease /disorder proneness /risk; echocardiography; gender difference; human subject; hypertension; insulin; lifestyle; longitudinal human study; nutrition related tag; racial /ethnic difference; smoking; social class; vascular resistance; young adult human (21-34)

Coronary Artery (Disease) Risk Development in (Young) Adults (CARDIA), is a longitudinal study of the distribution and evolution of risk factors for cardiovascular disease (CVD) in 5,115 18 to 30 year old black and white men and women with a range of attained education. CARDIA is designed to increase understanding of contributors to changes in CVD risk factors during the critical years of transition from adolescence through young adulthood to middle age. The primary objectives of CARDIA are: (1) to document at baseline and a approximately two to three year intervals, levels of risk factors for coronary artery disease and potential determinants of these risk factors in subjects 18 to 30 years old at the time of entry into the study; (2) to study the inter- relationships of risk factors and lifestyles and to document behavioral and environmental changes during the transition from adolescence to middle age; (3) to compare cross-sectional and longitudinal data on age- related trends in cardiovascular disease risk factors; and (4) to compare levels and evolution of risk factors between men and women blacks and whites, and in groups of differing socioeconomic status. Five examinations of the cohort have been conducted. Each examination has included the same core measurements, including blood pressure for tracking the development of hypertension, lipids, anthropometric measurements, smoking, physical activity and assessments of sociodemographic and other psychosocial characteristics. Fasting insulin/blood glucose levels were measured at baseline and at several later examinations to determine the association between insulin levels, diabetes, and cardiovascular disease. New measurements have been included at each examination, including echocardiography in Year 5 and 10; detailed quantitative dietary assessments and maximal, symptom- limited treadmill testing at baseline and year 7; 24 hour ambulatory blood pressure measurement; vascular distensibility; 72 hours urine collections for sodium, potassium, creatinine and magnesium; skin reflectance; selected psychological characteristics; vascular stiffness; and microalbuminuria. A pilot study of electron-beam computed tomography was conducted in Year 10 to assess coronary calcium.

（年轻）成人冠状动脉（疾病）风险发展（CARDIA）， 是对风险分布和演变的纵向研究 5，115名18至30岁的心血管疾病（CVD）因素 受过各种教育的黑人和白色男女。贲门 旨在增加对CVD变化的贡献者的理解 从青春期过渡的关键时期的风险因素 从青年到中年。Cardia的主要目标 （1）在基线和大约两到三年的时间内记录 间隔时间、冠状动脉疾病的风险因素水平， 18 - 30岁受试者中这些风险因素的潜在决定因素 （2）在进入研究时年龄较大;（3）研究间- 风险因素和生活方式的关系，并记录行为 从青春期过渡到 中年;（3）比较年龄的横向和纵向数据- 心血管疾病危险因素的相关趋势;以及（4） 比较男女风险因素的水平和演变情况 黑人和白人，以及不同社会经济地位的群体。 对这一组进行了五次检查。每次检查 包括相同的核心测量，包括血压， 跟踪高血压、血脂、人体测量 测量、吸烟、身体活动和评估 社会人口学和其他心理社会特征。空腹 在基线和几个时间点测量胰岛素/血糖水平。 随后的检查以确定胰岛素水平之间的关联， 糖尿病和心血管疾病。新的测量结果已经 包括每次检查，包括5年级的超声心动图， 10;详细的定量饮食评估和最大的，症状- 基线和第7年时的有限跑步机测试; 24小时门诊 血压测量;血管扩张性; 72小时尿 钠、钾、肌酸酐和镁的采集;皮肤 反射率;选择性心理特征;血管僵硬度; 和微量白蛋白尿。电子束CT的初步研究 在第10年进行，以评估冠状动脉钙。