STUDY CORONARY HEART DISEASE RISK IN YOUNG ADULTS

(青年)成人冠状动脉(疾病)风险发展(CARDIA) 是对风险的分布和演变的纵向研究 5,115名18~30岁人群心血管疾病相关因素分析 受过各种教育的黑人和白人男性和女性。CARDIA 旨在增加对CVD变化的贡献者的了解 青春期过渡关键时期的危险因素 从青壮年到中年。CARDIA的主要目标 是：(1)以基准记录，大约两到三年 间隔时间、冠心病危险因素水平和 18至30岁受试者中这些危险因素的潜在决定因素 在进入研究时年事已高；(2)研究 危险因素与生活方式的关系以及记录行为 从青春期到青春期的环境变化 中年；(3)比较年龄的横截面和纵向数据- 心血管疾病危险因素的相关趋势；及(4) 男性和女性危险因素水平和演变的比较 黑人和白人，以及不同社会经济地位的群体。 已经对队列进行了五次检查。每次考试 已经包括了相同的核心测量，包括 跟踪高血压、血脂、人体测量的发展 测量、吸烟、体力活动和评估 社会人口学和其他心理社会特征。禁食 胰岛素/血糖水平在基线和几个时间点被测量 随后的检查以确定胰岛素水平之间的关联， 糖尿病和心血管疾病。新的测量结果是 包括在每一次检查中，包括5年级和 10；详细的定量饮食评估和最大症状- 基线和第7年的有限跑步机测试；24小时不间断 血压测量；血管扩张性；72小时尿 钠、钾、肌酐和镁的收藏；皮肤 反射；选定的心理特征；血管僵硬； 和微量白蛋白尿。电子束CT的初步研究 是在第10年进行的，以评估冠状动脉钙化。

Coronary Artery (Disease) Risk Development in (Young) Adults (CARDIA), is a longitudinal study of the distribution and evolution of risk factors for cardiovascular disease (CVD) in 5,115 18 to 30 year old black and white men and women with a range of attained education. CARDIA is designed to increase understanding of contributors to changes in CVD risk factors during the critical years of transition from adolescence through young adulthood to middle age. The primary objectives of CARDIA are: (1) to document at baseline and a approximately two to three year intervals, levels of risk factors for coronary artery disease and potential determinants of these risk factors in subjects 18 to 30 years old at the time of entry into the study; (2) to study the inter- relationships of risk factors and lifestyles and to document behavioral and environmental changes during the transition from adolescence to middle age; (3) to compare cross-sectional and longitudinal data on age- related trends in cardiovascular disease risk factors; and (4) to compare levels and evolution of risk factors between men and women blacks and whites, and in groups of differing socioeconomic status. Five examinations of the cohort have been conducted. Each examination has included the same core measurements, including blood pressure for tracking the development of hypertension, lipids, anthropometric measurements, smoking, physical activity and assessments of sociodemographic and other psychosocial characteristics. Fasting insulin/blood glucose levels were measured at baseline and at several later examinations to determine the association between insulin levels, diabetes, and cardiovascular disease. New measurements have been included at each examination, including echocardiography in Year 5 and 10; detailed quantitative dietary assessments and maximal, symptom- limited treadmill testing at baseline and year 7; 24 hour ambulatory blood pressure measurement; vascular distensibility; 72 hours urine collections for sodium, potassium, creatinine and magnesium; skin reflectance; selected psychological characteristics; vascular stiffness; and microalbuminuria. A pilot study of electron-beam computed tomography was conducted in Year 10 to assess coronary calcium.