CALGB

描述（改编自申请人的摘要）：这是一个 多学科合作研究项目， 更有效的预防、检测和治疗人类 各种形式的癌症 这项研究的重点是医学的努力， 肿瘤学家，外科医生，放射治疗师，精神病学家，病理学家，基础 科学家、统计学家、流行病学家、护士、药剂师， 临床研究助理设计和进行的研究， 相关的临床和基础科学问题，其答案有助于 对患者护理和人群中癌症的减少有显著意义 其发展的风险越来越大。 该项目包括 以下内容：（1）新治疗药物的探索，及其 相关毒性，通过广泛的肿瘤性疾病， I、II和III研究;（2）评价 新的治疗方案，包括新旧药物的组合， 更有效地利用协同组合;（3）开发 针对特定肿瘤问题的多模式方法， 免疫学和放射学措施的最佳组合;（4） 生物化学等相关基础科学学科的参与， 药理学、细胞生物学和数学， 执行特定的治疗方案;（5）改善癌症 通过在教育工作中使用这些计划， 针对博士前和博士后学生、护士、专职医疗人员 （6）生物学研究的评价与 临床终点，以建立更合理的，基于癌症 （7）评估癌症控制工作，如早期 检测;和（8）癌症的心理社会方面的研究。 这 申请成为癌症和白血病B组常任理事国 代表了合作组临床研究的转折点， 活动的俄亥俄州州立大学，因为它离开其长期的 与西南肿瘤学小组的联系。 推动这一变化的是 招募克拉拉·D博士作者：Michael A.卡利久里， 阿尔伯特·德·拉夏贝尔 这些杰出的研究成果 调查人员与俄亥俄州的现有能力是协同的。 结合这些单独的优势将促进创新的发展 临床试验，特别是那些与基础科学相关的临床试验， 加强俄亥俄州癌症合作小组参与。

DESCRIPTION (adapted from the applicant's abstract): This is a multi-disciplinary collaborative research project for the development of more effective methods of prevention, detection, and treatment of human cancer in all its forms. This research focuses the efforts of medical oncologists, surgeons, radiotherapists, psychiatrists, pathologists, basic scientists, statisticians, epidemiologists, nurses, pharmacists, and clinical research associates on well designed and conducted studies asking interrelated clinical and basic science questions whose answers contribute significantly to patient care and to reduction of cancer within populations at increased risk for its development. Included in this project are the following: (1) the exploration of new therapeutic agents, and their associated toxicities, through a wide range of neoplastic diseases in Phase I, II, and III studies; (2) the evaluation of the efficacy and toxicity of new regimens including combinations of new and old agents in an effort to exploit synergistic combinations more effectively; (3) the development of multi-modal approaches to specific tumor problems using surgical, immunological, and radiotherapeutic measures in optimal combinations; (4) the involvement of pertinent basic science disciplines such as biochemistry, pharmacology, cellular biology, and mathematics in the formulation and execution of specific treatment protocols; (5) the improvement of cancer care in the community by using these programs in the educational effort directed at pre- and postdoctoral students, nurses, allied medical personnel and physicians; (6) the evaluation of biologic studies in correlation with clinical endpoints so as to build toward more rationally, based cancer management; (7) the evaluation of cancer control efforts such as early detection; and (8) the study of the psycho-social aspects of cancer. This application for permanent membership in the Cancer and Leukemia Group B represents a turning point in the cooperative group clinical research activities of The Ohio State University as it leaves its long-standing affiliation with the Southwest Oncology Group. Motivating this change is the recruitment of Drs. Clara D. Bloomfield, Michael A. Caligiuri, and Albert de la Chapelle. The research attributes of these outstanding investigators are synergistic with existing capabilities at Ohio State. Combining these separate strengths will enhance development of innovative clinical trials especially those with basic science correlates and strengthen Ohio State's cancer cooperative group participation.