EPIDEMIOLOGY OF KSHV AND AIDS-RELATED KAPOSIS SARCOMA

KSHV 和艾滋病相关卡波西斯肉瘤的流行病学

• 批准号: 2896228
• 负责人: LISA P JACOBSON
• 金额: $ 22.86万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-09-01 至 2001-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2896228
• 关键词: Kaposi's sarcoma; clinical research; human herpesvirus 8; human immunodeficiency virus 1; human subject; male; neoplasm /cancer epidemiology; sex behavior; substance abuse related disorder; virus related neoplasm /cancer

DESCRIPTION (adapted from the Abstract): The goal of this study is to define the epidemiology of HIV-1 related Kaposi's sarcoma (KS) as it relates to the putative causal agent, KS herpes virus (KSHV). A proposed historical cohort study nested within the Multicenter AIDS Cohort Study (MACS), a longitudinal prospective study of the natural history of HIV-1 infection in homosexual/ bisexual men, will address these specific aims: (1) determine the prevalence and incidence of KSHV infection in this population; (2) determine the KSHV route of transmission and the concordance of characteristics associated with the virus to risk factors for KS; (3) determine rates and biological markers of progression to KS among KSHV seropositive, HIV-1 infected homosexual men and factors which may modify disease progression; (4) examine the effect of anti-retroviral and anti-herpes treatments on KS disease progression in the presence of KSHV infection; and (5) examine the health effects of KSHV in the absence of HIV-1 and the effect of KSHV on HIV-1 progression independent of its role in KS disease. Behaviors to be examined as risk factors include numbers of male sexual partners and types of sexual activities (e.g., anal/genital intercourse, anal/oral intercourse, genital/oral intercourse) and recreational drug use (e.g., nitrite inhalants). Host characteristics including age, race and immune status will be examined as effect modifiers for viral acquisition and disease progression. The effects of other environmental factors such as geographic location and co-infections will be studied, also. KSHV serological testing will be performed on selected visits for 414 HIV-1 seroconverters with known dates of seroconversion within 1 year and a stratified random sample of 400 HIV-1 seroprevalent and 100 seronegative men. KSHV seroprevalence also will be determined in a sample of injecting drug users from a cohort study with protocols similar as the MACS. Establishing the epidemiology of the KSHV, consistent with principles of causality, will provide direction for developing behavioral and therapeutic interventions against the development of KS and will guide virological and biological investigations determining the pathogenesis of this disease.

描述(改编自摘要)：本研究的目标是 界定与HIV-1相关的卡波西肉瘤(KS)的流行病学 可能的病原体是KS疱疹病毒(KSHV)。一项拟议的历史 嵌套在多中心艾滋病队列研究(MACS)中的队列研究，a 安徽省HIV-1感染自然史的纵向前瞻性研究 男同性恋者/双性恋者，将解决这些具体目标：(1)确定 该人群中KSHV感染的患病率和发病率；(2) 确定KSHV传播途径及其与 与病毒相关的特征与KS的危险因素；(3) KSHV向KS进展率及生物学标志的测定 血清阳性、感染HIV-1的同性恋男性及其可能改变的因素 疾病进展；(4)检测抗逆转录病毒和 抗疱疹治疗对KSHV感染的KS疾病进展的影响 感染；以及(5)在没有KSHV感染的情况下检查KSHV对健康的影响 HIV-1及KSHV对HIV-1进展的影响 KS病。作为风险因素进行审查的行为包括 男性性伙伴和性活动类型(例如，肛门/生殖器 性交、肛交/口交、生殖器/口交)和 娱乐用药(例如亚硝酸盐吸入剂)。寄主特征 包括年龄、种族和免疫状况在内的因素将作为效果修饰物进行检查 用于病毒感染和疾病进展。其他因素的影响 地理位置和混合感染等环境因素将是 也学过了。将对选定的KSHV进行血清学检测 已知血清转换日期的414名HIV-1血清转换者的就诊情况 在1年内，对400名HIV-1血清流行者和 100名血清阴性的男性。KSHV血清阳性率也将在 一项队列研究中注射吸毒者的样本，方案类似于 Mac电脑。建立KSHV的流行病学，与 因果关系原则，将为行为学的发展提供方向 和针对KS发展的治疗干预，并将指导 病毒学和生物学研究确定该病的发病机制 这种病。

项目成果

CD8+ cytotoxic T lymphocyte responses to lytic proteins of human herpes virus 8 in human immunodeficiency virus type 1-infected and -uninfected individuals.

在人类免疫缺陷病毒 1 型感染和未感染个体中，CD8 细胞毒性 T 淋巴细胞对人类疱疹病毒 8 裂解蛋白的反应。

• DOI: 10.1086/315777
• 发表时间: 2000
• 期刊: The Journal of infectious diseases
• 作者: Wang,QJ;Jenkins,FJ;Jacobson,LP;Meng,YX;Pellett,PE;Kingsley,LA;Kousoulas,KG;Baghian,A;RinaldoJr,CR
• 通讯作者: RinaldoJr,CR

Identification of an HLA A*0201-restricted CD8(+) T-cell epitope for the glycoprotein B homolog of human herpesvirus 8.

• DOI: 10.1182/blood.v99.9.3360
• 发表时间: 2002-05
• 期刊: Blood
• 影响因子: 20.3
• 作者: Qiong J. Wang;Xiao-li Huang;G. Rappocciolo;F. Jenkins;W. Hildebrand;Zheng Fan;E. Thomas;C. Rinaldo