EPIDEMIOLOGY OF KSHV AND AIDS-RELATED KAPOSIS SARCOMA
EPIDEMIOLOGY OF KSHV AND AIDS-RELATED KAPOSIS SARCOMA
批准号:
2439683
负责人:
LISA P JACOBSON
金额:
$23.57万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
1997
资助国家:
美国
项目状态:
已结题
起止时间:
1997-09-01 至 2000-08-31
中文摘要
描述(改编自摘要):本研究的目标是
界定与HIV-1相关的卡波西肉瘤(KS)的流行病学
可能的病原体是KS疱疹病毒(KSHV)。一项拟议的历史
嵌套在多中心艾滋病队列研究(MACS)中的队列研究,a
安徽省HIV-1感染自然史的纵向前瞻性研究
男同性恋者/双性恋者,将解决这些具体目标:(1)确定
该人群中KSHV感染的患病率和发病率;(2)
确定KSHV传播途径及其与
与病毒相关的特征与KS的危险因素;(3)
KSHV向KS进展率及生物学标志的测定
血清阳性、感染HIV-1的同性恋男性及其可能改变的因素
疾病进展;(4)检测抗逆转录病毒和
抗疱疹治疗对KSHV感染的KS疾病进展的影响
感染;以及(5)在没有KSHV感染的情况下检查KSHV对健康的影响
HIV-1及KSHV对HIV-1进展的影响
KS病。作为风险因素进行审查的行为包括
男性性伙伴和性活动类型(例如,肛门/生殖器
性交、肛交/口交、生殖器/口交)和
娱乐用药(例如亚硝酸盐吸入剂)。寄主特征
包括年龄、种族和免疫状况在内的因素将作为效果修饰物进行检查
用于病毒感染和疾病进展。其他因素的影响
地理位置和混合感染等环境因素将是
也学过了。将对选定的KSHV进行血清学检测
已知血清转换日期的414名HIV-1血清转换者的就诊情况
在1年内,对400名HIV-1血清流行者和
100名血清阴性的男性。KSHV血清阳性率也将在
一项队列研究中注射吸毒者的样本,方案类似于
Mac电脑。建立KSHV的流行病学,与
因果关系原则,将为行为学的发展提供方向
和针对KS发展的治疗干预,并将指导
病毒学和生物学研究确定该病的发病机制
这种病。
英文摘要
DESCRIPTION (adapted from the Abstract): The goal of this study is to
define the epidemiology of HIV-1 related Kaposi's sarcoma (KS) as it relates
to the putative causal agent, KS herpes virus (KSHV). A proposed historical
cohort study nested within the Multicenter AIDS Cohort Study (MACS), a
longitudinal prospective study of the natural history of HIV-1 infection in
homosexual/ bisexual men, will address these specific aims: (1) determine
the prevalence and incidence of KSHV infection in this population; (2)
determine the KSHV route of transmission and the concordance of
characteristics associated with the virus to risk factors for KS; (3)
determine rates and biological markers of progression to KS among KSHV
seropositive, HIV-1 infected homosexual men and factors which may modify
disease progression; (4) examine the effect of anti-retroviral and
anti-herpes treatments on KS disease progression in the presence of KSHV
infection; and (5) examine the health effects of KSHV in the absence of
HIV-1 and the effect of KSHV on HIV-1 progression independent of its role in
KS disease. Behaviors to be examined as risk factors include numbers of
male sexual partners and types of sexual activities (e.g., anal/genital
intercourse, anal/oral intercourse, genital/oral intercourse) and
recreational drug use (e.g., nitrite inhalants). Host characteristics
including age, race and immune status will be examined as effect modifiers
for viral acquisition and disease progression. The effects of other
environmental factors such as geographic location and co-infections will be
studied, also. KSHV serological testing will be performed on selected
visits for 414 HIV-1 seroconverters with known dates of seroconversion
within 1 year and a stratified random sample of 400 HIV-1 seroprevalent and
100 seronegative men. KSHV seroprevalence also will be determined in a
sample of injecting drug users from a cohort study with protocols similar as
the MACS. Establishing the epidemiology of the KSHV, consistent with
principles of causality, will provide direction for developing behavioral
and therapeutic interventions against the development of KS and will guide
virological and biological investigations determining the pathogenesis of
this disease.
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ECHODAC (Environmental Influences on Child Health Outcomes Data Analysis Center)
-
批准号:9355710
-
项目类别:
-
资助金额:$1013.16万
-
财政年份:2016
-
负责人:LISA P JACOBSON
-
依托单位:
ECHODAC (Environmental Influences on Child Health Outcomes Data Analysis Center)
-
批准号:10015366
-
项目类别:
-
资助金额:$1664.36万
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财政年份:2016
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负责人:LISA P JACOBSON
-
依托单位:
Center/Coordination, Analysis and Management/MACS
-
批准号:8072924
-
项目类别:
-
资助金额:$13.66万
-
财政年份:2010
-
负责人:LISA P JACOBSON
-
依托单位:
Center for the Analysis & Management of the Multicenter AIDS Cohort Study
-
批准号:7725473
-
项目类别:
-
资助金额:$251.09万
-
财政年份:2009
-
负责人:LISA P JACOBSON
-
依托单位:
Center/Coordination, Analysis and Management/MACS
-
批准号:7924394
-
项目类别:
-
资助金额:$49.26万
-
财政年份:2009
-
负责人:LISA P JACOBSON
-
依托单位:
EPIDEMIOLOGY OF KSHV AND AIDS-RELATED KAPOSIS SARCOMA
-
批准号:2769985
-
项目类别:
-
资助金额:$22.3万
-
财政年份:1997
-
负责人:LISA P JACOBSON
-
依托单位:
EPIDEMIOLOGY OF KSHV AND AIDS-RELATED KAPOSIS SARCOMA
-
批准号:2896228
-
项目类别:
-
资助金额:$22.86万
-
财政年份:1997
-
负责人:LISA P JACOBSON
-
依托单位:
EPIDEMIOLOGY OF KSHV AND AIDS RELATED KAPOSIS SARCOMA
-
批准号:2878002
-
项目类别:
-
资助金额:$9.98万
-
财政年份:1997
-
负责人:LISA P JACOBSON
-
依托单位:
Center/Coordination, Analysis and Management/MACS
-
批准号:8242864
-
项目类别:
-
资助金额:$279.18万
-
财政年份:1993
-
负责人:LISA P JACOBSON
-
依托单位:
Center/Coordination, Analysis and Management/MACS
-
批准号:7638686
-
项目类别:
-
资助金额:$251.09万
-
财政年份:1993
-
负责人:LISA P JACOBSON
-
依托单位:
Center/Coordination, Analysis and Management/MACS
-
批准号:8699878
-
项目类别:
-
资助金额:$262.32万
-
财政年份:1993
-
负责人:LISA P JACOBSON
-
依托单位:
Center/Coordination, Analysis and Management/MACS
-
批准号:8447556
-
项目类别:
-
资助金额:$203.65万
-
财政年份:1993
-
负责人:LISA P JACOBSON
-
依托单位:
Center/Coordination, Analysis and Management/MACS
-
批准号:8829129
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项目类别:
-
资助金额:$267.02万
-
财政年份:1993
-
负责人:LISA P JACOBSON
-
依托单位:
Center/Coordination, Analysis and Management/MACS-Part B
-
批准号:6884847
-
项目类别:
-
资助金额:$213.8万
-
财政年份:1993
-
负责人:LISA P JACOBSON
-
依托单位:
Center/Coordination, Analysis and Management/MACS-Part B
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批准号:7221204
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项目类别:
-
资助金额:$229.41万
-
财政年份:1993
-
负责人:LISA P JACOBSON
-
依托单位:
Center/Coordination, Analysis and Management/MACS
-
批准号:7805469
-
项目类别:
-
资助金额:$258.73万
-
财政年份:1993
-
负责人:LISA P JACOBSON
-
依托单位:
Center/Coordination, Analysis and Management/MACS-Part B
-
批准号:7392695
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项目类别:
-
资助金额:$232.04万
-
财政年份:1993
-
负责人:LISA P JACOBSON
-
依托单位:
Center/Coordination, Analysis and Management/MACS-Part B
-
批准号:7038228
-
项目类别:
-
资助金额:$235.53万
-
财政年份:1993
-
负责人:LISA P JACOBSON
-
依托单位:
Center/Coordination, Analysis and Management/MACS
-
批准号:8058721
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项目类别:
-
资助金额:$243.93万
-
财政年份:1993
-
负责人:LISA P JACOBSON
-
依托单位:
Center/Coordination, Analysis and Management/MACS-Part B
-
批准号:6793796
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项目类别:
-
资助金额:$224.74万
-
财政年份:1993
-
负责人:LISA P JACOBSON
-
依托单位:
海外基金