DRUG ABUSE AND OTHER DEVIANT ADAPTATIONS TO STRESS

这是对K05高级科学家的竞争性续聘请求 奖品。广泛的目标包括研究、职业发展和 指导目标。研究的目的是从理论上估计 知情模型，具体说明(1)心理社会前因和 药物使用模式和其他偏差适应的后果 压力和为一群人缓和这些关系的结构 从青春期早期到第四个十年的生命周期 生命，(2)世代之间的连续性和间断性( 队列及其青春期子女)吸毒模式和其他 偏差适应，以及它们的相关性在可比的 两代人的发育阶段(青春期早期)，以及(3) 吸毒模式的心理社会前因和后果 以及其他对压力的偏离适应和温和的结构 这些关系适用于第二代队列。的数据。 第一组模特来自与一个小组的家庭访谈 年龄在35岁左右的受试者，这些受试者在较早的时候 20岁，在此之前，在7年级、8年级和9年级。模特们 详细说明早期生命阶段对后期生活的直接和间接影响 阶段，并指定缓和 效果。第二套模型的数据来自家庭 采访队列中达到父母年龄的孩子 是在青春期早期第一次接受采访时。型号将占到 对于世代之间的(不连续)，通过指定中介 和共同的前因变量。第三组模型的数据如下 通过对第二代青少年的重新采访提供了三个 基准线之后的几年。第一波变量将被建模为 对第二代有直接和温和的影响 重审受试者。模型将使用Structure进行估计 在其他方法中，方程式方法。加强研究工作 技能将侧重于方法学的发展，新发现 生命历程和代际影响的文献，以及 在其他纵向研究中与研究人员合作。 辅导活动包括指导研究生，他们是 受雇于该项目和药物滥用领域的研讨会 以及研究药物滥用的方法。

This is a competing continuation request for a K05 Senior Scientist Award. The broad objectives include research, career enhancement and mentoring goals. The research objective is to estimate theoretically informed models that specify (1) the psychosocial antecedents and consequences of patterns of drug use and other deviant adaptations to stress and the constructs that moderate these relationships for a cohort over the life span between early adolescence and the fourth decade of life, (2) continuities and discontinuities across generations (the cohort and their adolescent children) of patterns of drug use and other deviant adaptations, and their correlates observed at a comparable developmental stage (early adolescence) for the two generations, and (3) the psychosocial antecedents and consequences of patterns of drug use and other deviant adaptations to stress and the constructs that moderate these relationships for the second generation cohort. Data for the first set of models are from household interviews with a panel of subjects in their mid-to-late-30s who were earlier interviewed in their 20s and, prior to that, during the 7th, 8th, and 9th grades. The models specify direct and indirect effects of earlier life stages on later stages and specify the circumstances that moderate the nature of the effects. Data for the second set of models are from household interviews with the children of the cohort who reach the age the parent was when first interviewed in early adolescence. Models will account for (dis)continuities between the generations by specifying mediating and common antecedent variables. Data for the third set of models are provided by reinterviews with the second-generation adolescents three years following baseline. First wave variables will be modeled as having direct and moderating influences upon the second generation subjects at reinterview. The models will be estimated using structural equation approaches among other methodologies. Enhancement of research skills will focus upon methodological developments, new findings in the life course and intergenerational influence literatures, and collaboration with investigators in other longitudinal studies. Mentoring activities include guidance of graduate students who are employed on the project and in seminars in the areas of substance abuse and methods of research on drug abuse.