DRUG ABUSE AND OTHER DEVIANT ADAPTATIONS TO STRESS

这是K05高级科学家的竞争性继续申请 奖 广泛的目标包括研究，职业提升和 指导目标。 研究目的是从理论上估计 知情模型，指定（1）心理社会前因， 毒品使用模式和其他异常适应的后果 压力以及调节队列中这些关系的结构 从青春期早期到20世纪40年代， 生命，（2）跨代的连续性和不连续性（ 群体及其青少年儿童）的吸毒模式和其他 异常适应，以及他们的相关性，观察到在一个可比的 两代人的发育阶段（青春期早期），以及（3） 吸毒模式的社会心理前因和后果 以及其他对压力的异常适应， 第二代的关系。 数据 第一组模型来自家庭访谈， 30多岁的受试者，他们在早期接受了采访， 20多岁，在那之前，在七年级，八年级和九年级。 模型 具体说明早期生命阶段对后期的直接和间接影响 阶段和具体情况下，缓和的性质， 方面的影响. 第二组模型的数据来自家庭 与同龄人中达到父母年龄的儿童进行访谈， 是在青春期早期第一次接受采访时。 模型将考虑 对于世代之间的（不）连续性，通过指定中介 和共同的前因变量。 第三组模型的数据是 通过对第二代青少年的重新采访， 基线后的年数。 第一波变量将建模为 对第二代有直接和缓和的影响 重新面试的对象。 模型将使用结构化 在其他方法中采用等式方法。 加强研究 技能将侧重于方法的发展， 生命历程和代际影响文学， 与其他纵向研究中的研究人员合作。 指导活动包括指导研究生谁是 在药物滥用领域的项目和研讨会上任职 和研究药物滥用的方法。

This is a competing continuation request for a K05 Senior Scientist Award. The broad objectives include research, career enhancement and mentoring goals. The research objective is to estimate theoretically informed models that specify (1) the psychosocial antecedents and consequences of patterns of drug use and other deviant adaptations to stress and the constructs that moderate these relationships for a cohort over the life span between early adolescence and the fourth decade of life, (2) continuities and discontinuities across generations (the cohort and their adolescent children) of patterns of drug use and other deviant adaptations, and their correlates observed at a comparable developmental stage (early adolescence) for the two generations, and (3) the psychosocial antecedents and consequences of patterns of drug use and other deviant adaptations to stress and the constructs that moderate these relationships for the second generation cohort. Data for the first set of models are from household interviews with a panel of subjects in their mid-to-late-30s who were earlier interviewed in their 20s and, prior to that, during the 7th, 8th, and 9th grades. The models specify direct and indirect effects of earlier life stages on later stages and specify the circumstances that moderate the nature of the effects. Data for the second set of models are from household interviews with the children of the cohort who reach the age the parent was when first interviewed in early adolescence. Models will account for (dis)continuities between the generations by specifying mediating and common antecedent variables. Data for the third set of models are provided by reinterviews with the second-generation adolescents three years following baseline. First wave variables will be modeled as having direct and moderating influences upon the second generation subjects at reinterview. The models will be estimated using structural equation approaches among other methodologies. Enhancement of research skills will focus upon methodological developments, new findings in the life course and intergenerational influence literatures, and collaboration with investigators in other longitudinal studies. Mentoring activities include guidance of graduate students who are employed on the project and in seminars in the areas of substance abuse and methods of research on drug abuse.