GENE ENVIRONMENT STUDY OF TYPE 2 DIABETES IN FAMILIES

2型糖尿病家族基因环境研究

• 批准号: 2900351
• 负责人: JILL M NORRIS
• 金额: $ 57.63万
• 依托单位: UNIVERSITY OF COLORADO DENVER
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-08-20 至 2003-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2900351
• 关键词: Hispanic Americans; body physical activity; caucasian American; clinical research; diabetes mellitus genetics; diet; disease /disorder proneness /risk; family genetics; gene environment interaction; genetic markers; genetic polymorphism; genetic susceptibility; genotype; human genetic material tag; human subject; linkage disequilibriums; noninsulin dependent diabetes mellitus; nutrition related tag; phenotype

DESCRIPTION: (Adapted from Investigator's Abstract) The purpose of this project is to locate the genes for and describe the genetic basis of type 2 diabetes, while accounting for environmental risk factors. Type 2 diabetes is a common heterogeneous disorder with evidence for both genetic and environmental causes. However, despite evidence for a strongly inherited component, major susceptibility genes have so far not been found for the more common forms of type 2 diabetes. The investigators propose that incorporating the known influence of environmental factors such as diet and physical activity into analyses will improve the power to measure the association and linkage between genetic markers and diabetes. Recent advances in analytic techniques that allow testing for genetic association and linkage in complex diseases such as type 2 diabetes, while also testing for gene-environment interaction, will make this approach possible. The proposed study is a family study design. All nuclear families identified from the San Luis Valley Diabetes Study Cohort in which there is at least one affected in a sibship will be studied, with the goal of maximizing the number of families that can be used in transmission-disequilibrium analyses. Approximately 2000 parents and offspring will be genotyped for candidate genes and candidate regions that have been, or will be, discovered through independent genome scans for diabetes genes. Phenotypic and environmental data (e.g., physical activity and dietary histories) will be collected from the offspring. They will use transmission-disequilibrium test methods of analysis on 560 Hispanic and 457 non-Hispanic white "trios" to identify and localize genes associated with type 2 diabetes, while accounting for interactions with diet and physical activity.

描述：（改编自研究者摘要）本项目的目的 是定位2型糖尿病的基因并描述其遗传基础， 同时考虑到环境风险因素。2型糖尿病是一种常见的 遗传和环境原因证据的异质性疾病。 然而，尽管有证据表明有很强的遗传成分， 到目前为止，尚未发现更常见形式的易感基因。 2型糖尿病研究人员建议，将已知的 环境因素，如饮食和体力活动， 分析将提高衡量关联和联系的能力， 遗传标记和糖尿病分析技术的最新进展， 检测复杂疾病的遗传关联和连锁，如2型 糖尿病，同时也测试基因-环境相互作用，将使这一点， 接近可能。 本研究是一项家庭研究设计。所有核心家庭都已确定 来自圣路易斯谷糖尿病研究队列，其中至少有一个 受影响的兄弟姐妹将被研究，目标是最大限度地增加 可以用于传播不平衡分析。 大约2000名父母和后代将进行候选基因的基因分型 以及已经或将要被发现的候选区域， 对糖尿病基因进行独立的基因组扫描。表型和环境数据 (e.g.,身体活动和饮食史）将从 后代他们将使用传播不平衡测试的分析方法 对560名西班牙裔和457名非西班牙裔白色“三人组”进行识别和定位 与2型糖尿病相关的基因，同时考虑与 饮食和身体活动。