GENE ENVIRONMENT STUDY OF TYPE 2 DIABETES IN FAMILIES

描述：(改编自《调查者摘要》)本项目的目的 定位2型糖尿病的基因并描述其遗传基础， 同时考虑了环境风险因素。2型糖尿病是一种常见的 有遗传和环境两方面原因的证据的异质性疾病。 然而，尽管有证据表明这是一个强烈继承的组件，但主要 到目前为止，还没有发现更常见的形式的易感基因 2型糖尿病。调查人员建议将已知的 饮食和体力活动等环境因素对健康的影响 分析将提高衡量两者之间的关联和联系的能力 遗传标记和糖尿病。分析技术的最新进展，使 2型等复杂疾病的遗传关联和连锁检测 糖尿病，同时也测试基因与环境的相互作用，将使这一点 有可能接近。 建议的研究是一项家庭研究设计。所有核心家庭都已确定 来自圣路易斯谷糖尿病研究队列，其中至少有一个 将研究受兄弟姐妹关系影响的人，目标是使人数最大化 可用于传输不平衡分析的族。 大约2000名父母和子女将接受候选基因的基因分型。 以及已经或将被发现的候选区域 独立的基因组扫描糖尿病基因。表型和环境数据 (例如，体力活动和饮食历史)将从 后代。他们将使用传输不平衡检验的分析方法 关于560名西班牙裔和457名非西班牙裔白人的身份识别和本地化 与2型糖尿病相关的基因，同时解释了与 饮食和体力活动。

DESCRIPTION: (Adapted from Investigator's Abstract) The purpose of this project is to locate the genes for and describe the genetic basis of type 2 diabetes, while accounting for environmental risk factors. Type 2 diabetes is a common heterogeneous disorder with evidence for both genetic and environmental causes. However, despite evidence for a strongly inherited component, major susceptibility genes have so far not been found for the more common forms of type 2 diabetes. The investigators propose that incorporating the known influence of environmental factors such as diet and physical activity into analyses will improve the power to measure the association and linkage between genetic markers and diabetes. Recent advances in analytic techniques that allow testing for genetic association and linkage in complex diseases such as type 2 diabetes, while also testing for gene-environment interaction, will make this approach possible. The proposed study is a family study design. All nuclear families identified from the San Luis Valley Diabetes Study Cohort in which there is at least one affected in a sibship will be studied, with the goal of maximizing the number of families that can be used in transmission-disequilibrium analyses. Approximately 2000 parents and offspring will be genotyped for candidate genes and candidate regions that have been, or will be, discovered through independent genome scans for diabetes genes. Phenotypic and environmental data (e.g., physical activity and dietary histories) will be collected from the offspring. They will use transmission-disequilibrium test methods of analysis on 560 Hispanic and 457 non-Hispanic white "trios" to identify and localize genes associated with type 2 diabetes, while accounting for interactions with diet and physical activity.