NUTRITIONAL ETIOLOGY OF PREDIABETTIC AUTOIMMUNITY

一个队列的567名新生儿在中度和高度遗传风险的胰岛素依赖型糖尿病，正在跟踪通过婴儿期和幼儿期的自身免疫的发展在年轻的糖尿病自身免疫研究（DAISY）。将在3、6、9、12和15个月大时收集婴儿饮食数据。建议在2岁、3岁、4岁、5岁和6岁时收集儿童早期饮食数据。 将在9个月、15个月、2岁、3岁、4岁、5岁和6岁时从队列中采集血样。 将在这些时间点分析主要结局，特异性胰岛细胞自身抗原的自身抗体。 将使用567个个体的整个队列来检查膳食摄入抗氧化剂在β细胞自身免疫（BCA）风险中的作用。 将对230名个体（55名患有BCA的儿童和175名没有BCA的儿童，其中测量抗氧化剂的血浆水平）进行病例队列研究。 主要的研究问题将集中在哪些成分（或成分组合），抗氧化剂摄入的剂量或时间以及血浆抗氧化剂与糖尿病相关自身抗体的出现和缓解相关。

A cohort of 567 newborns at moderate and high genetic risk for IDDM, is being followed through infancy and early childhood for the development of autoimmunity by the Diabetes Autoimmunity Study in the Young (DAISY). Data will be collected on the infant diet at 3, 6, 9, 12, and 15 months of age. At the ages of 2, 3, 4, 5, and 6 years it is proposed to collect early childhood diet data. Blood samples will be collected from the cohort at the ages of 9 months, 15 months, 2, 3, 4, 5, and 6 years. The primary outcome, autoantibodies to specific islet-cell autoantigens, will be analyzed at these time points. The role of dietary intake of anti-oxidants in the risk of beta-cell autoimmunity (BCA) using the whole cohort of 567 individuals will be examined. A case-cohort study of 230 individuals (55 children with BCA and 175 children without BCA, in which plasma levels of anti-oxidants are measured) will be conducted. The primary research questions will focus on what components (or combination of components), dose or timing of anti-oxidant intake and plasma anti-oxidants are associated with the appearance and remission of diabetes-related autoantibodies.