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GENE ENVIRONMENT STUDY OF TYPE 2 DIABETES IN FAMILIES

2型糖尿病家族基因环境研究

基本信息

批准号：
6523766
负责人：
JILL M NORRIS
金额：
$ 55.95万
依托单位：
UNIVERSITY OF COLORADO DENVER
依托单位国家：
美国
项目类别：
财政年份：
1999
资助国家：
美国
起止时间：
1999-08-20 至 2004-07-31
项目状态：
已结题

项目摘要

DESCRIPTION: (Adapted from Investigator's Abstract) The purpose of this project is to locate the genes for and describe the genetic basis of type 2 diabetes, while accounting for environmental risk factors. Type 2 diabetes is a common heterogeneous disorder with evidence for both genetic and environmental causes. However, despite evidence for a strongly inherited component, major susceptibility genes have so far not been found for the more common forms of type 2 diabetes. The investigators propose that incorporating the known influence of environmental factors such as diet and physical activity into analyses will improve the power to measure the association and linkage between genetic markers and diabetes. Recent advances in analytic techniques that allow testing for genetic association and linkage in complex diseases such as type 2 diabetes, while also testing for gene-environment interaction, will make this approach possible. The proposed study is a family study design. All nuclear families identified from the San Luis Valley Diabetes Study Cohort in which there is at least one affected in a sibship will be studied, with the goal of maximizing the number of families that can be used in transmission-disequilibrium analyses. Approximately 2000 parents and offspring will be genotyped for candidate genes and candidate regions that have been, or will be, discovered through independent genome scans for diabetes genes. Phenotypic and environmental data (e.g., physical activity and dietary histories) will be collected from the offspring. They will use transmission-disequilibrium test methods of analysis on 560 Hispanic and 457 non-Hispanic white "trios" to identify and localize genes associated with type 2 diabetes, while accounting for interactions with diet and physical activity.

描述：（改编自研究者摘要）该项目的目的是定位2型糖尿病的基因并描述2型糖尿病的遗传基础，同时考虑环境风险因素。 2 型糖尿病是一种常见的具有遗传和环境原因证据的异质性疾病。然而，尽管有证据表明存在强烈的遗传成分，但主要迄今为止，尚未发现更常见形式的易感基因 2型糖尿病。研究人员建议将已知的饮食和体力活动等环境因素的影响分析将提高衡量之间关联和联系的能力遗传标记与糖尿病。分析技术的最新进展使得测试 2 型等复杂疾病的遗传关联和连锁糖尿病，同时也测试基因与环境的相互作用，将使这方法可行。拟议的研究是一项家庭研究设计。所有核心家庭均已确定来自圣路易斯谷糖尿病研究队列，其中至少有一个将研究同胞关系中受影响的因素，目标是最大限度地增加受影响的人数可用于传递不平衡分析的家族。大约 2000 个父母和后代将对候选基因进行基因分型以及已经或将要发现的候选区域独立的基因组扫描糖尿病基因。表型和环境数据（例如身体活动和饮食历史）将从后代。他们将使用传递不平衡测试方法进行分析对 560 名西班牙裔和 457 名非西班牙裔白人“三人组”进行识别和定位与 2 型糖尿病相关的基因，同时考虑与饮食和身体活动。