The Exposome in Rheumatoid Arthritis and Systemic Lupus Erythematosus: EXACT Network Planning

类风湿关节炎和系统性红斑狼疮的暴露组：精确的网络规划

• 批准号: 10869439
• 负责人: JILL M NORRIS
• 金额: $ 44.9万
• 依托单位: UNIVERSITY OF COLORADO DENVER
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-09-19 至 2025-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10869439
• 关键词: Address; Advocate; Air Pollution; Antibodies; Area; Autoantibodies; Autoimmune; Autoimmune Diseases; Autoimmunity; Biological; Biological Markers; Biomedical Research; Chemicals; Chronic; Climate; Clinical; Collaborations; Colorado; Complex; Data; Data Analyses; Data Collection; Databases; Development; Diet; Disease; Environmental Exposure; Environmental Risk Factor; Etiology; Evolution; Exhibits; Exploratory/Developmental Grant; Food; Foundations; Future; Genes; Genetic; Genetic Risk; Goals; Health Food; Hormones; Human Herpesvirus 4; Individual; Inflammation; Inflammatory; Infrastructure; Interdisciplinary Study; Laboratories; Life Cycle Stages; Measurement; Measures; Medical; Medical Research; Methods; Natural History; Obesity; Occupational; Oklahoma; Omega-3 Fatty Acids; Outcome; Patients; Pesticides; Phase; Plasma; Policies; Population; Prevention; Process; Professional Organizations; Prospective Studies; Prospective cohort; Psychosocial Stress; Questionnaires; Recording of previous events; Registries; Research; Research Personnel; Research Project Grants; Resolution; Resources; Rheumatoid Arthritis; Risk; Role; Sampling; Science; Severity of illness; Silicon Dioxide; Site; Smoking; Societal Factors; Source; Systemic Lupus Erythematosus; Techniques; Testing; Translations; Universities; Vitamins; Weather; Work; chemokine; clinical development; cohort; cytokine; data integration; design; disorder risk; epidemiology study; gut microbiome; health care availability; lipid mediator; lung microbiome; novel; oral microbiome; peripheral blood; pre-clinical; prospective; repository; seropositive; social; symposium

PROJECT SUMMARY This is an exploratory developmental grant aimed at the design, development, and implementation of a future national, interdisciplinary, collaborative, team science research network that will advance the study of the exposome in autoimmune diseases (Exposome in Autoimmune Diseases Collaborating Teams, EXACT). We propose to plan a study of the exposome during the pre-clinical period of rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE). We assert that it is important to measure the exposome prior to the development of disease to ensure that what we are measuring precedes the disease and is not a consequence of the disease (which might happen if the exposome were measured in diseased individuals). This will allow us to draw inference about the temporality and potential causality of exposures on the risk of RA and SLE. This can be accomplished using prospective cohorts of at-risk individuals that are followed for the development of clinical disease (ie classifiable RA and SLE) with which we have a long history of working. Investigators at the University of Colorado Anschutz Medical Campus (Norris, Holers and Abraham) will work with investigators at the Oklahoma Medical Research Foundation (James and Munroe) to conduct a landscape analysis of relevant existing 1) resources, populations, databases, registries, repositories and consortia, 2) data on relevant exposures, 3) exposome laboratories, and 4) exposome analytic techniques. This will provide a background that we will use to plan activities for a new project to study the exposome in RA and SLE. As part of the planning process, we will hold a summit of exposome experts and investigators with cohorts/populations of individuals at-risk for RA and SLE, to develop and expand existing research collaborations to conduct a prospective study in the exposome of these diseases. We will use our existing novel cohorts of at-risk individuals who have been followed to the development of classifiable RA and SLE to explore feasibility of harmonization of questionnaire and biomarker data and conduct secondary data analysis to support the hypothesis and research strategy of the future EXACT Network. We will engage stakeholders such as scientific or professional associations and patients and patient-advocates in the areas of RA and SLE for better translation to inform the EXACT Network research agenda. The overall goal of this proposal is to plan research strategies and develop partnerships, infrastructure, and capabilities needed to address the major goals of a future collaborative EXACT network and to develop a research framework and strategies to support coordination among studies, collaborative research projects, and sites. Specific Aim 1. To conduct a multipronged approach to determine the needs and currently available resources to prospectively and effectively measure the exposome in RA and SLE (via a landscape analysis). Specific Aim 2. To design a prospective study to examine the role of the exposome in the etiology of RA and SLE, with an interdisciplinary research team, rigorous exposome measurements and novel analytic approaches.

项目摘要 这是针对未来的设计，开发和实施的探索性发展赠款 国家，跨学科，合作，团队科学研究网络，将推进研究 自身免疫性疾病中的杂物体（自身免疫性疾病中的exposome合作团队的确切疾病）。我们 建议在类风湿关节炎（RA）和 全身性红斑狼疮（SLE）。我们断言，在衡量杂物之前很重要 疾病的发展以确保我们正在测量的疾病先前疾病，而不是结果 疾病（如果在患病的个体中测量过示例，可能会发生这种情况）。这将使我们 提出有关暴露于RA和SLE风险的时间性和潜在因果关系的推论。这 可以使用遵循遵循的高危个人的前瞻性人群来完成 临床疾病（即可分类的RA和SLE），我们有悠久的工作历史。调查人员 科罗拉多大学安索斯大学医学校园（诺里斯，霍尔斯和亚伯拉罕）将与调查员合作 俄克拉荷马州医学研究基金会（James and Munroe）进行相关的景观分析 现有1）资源，人群，数据库，注册表，存储库和财团，2）有关的数据 曝光，3）释放体实验室和4）释放分析技术。这将提供背景 我们将用于计划一个新项目的活动，以研究RA和SLE中的展览会。作为一部分 规划过程，我们将举行宣传专家和调查员的首脑会议 个人在RA和SLE的危险中，开发和扩展现有的研究合作，以进行 这些疾病的博览会的前瞻性研究。我们将使用现有的新颖的高危人群 遵循可分类的RA和SLE开发的个人，以探索可行性 调查表和生物标志物数据的协调并进行次要数据分析以支持 未来确切网络的假设和研究策略。我们将吸引利益相关者，例如科学 或专业协会，患者以及在RA和SLE地区的患者顾问，以提高 翻译以告知确切的网络研究议程。该提案的总体目标是计划研究 策略和建立伙伴关系，基础设施和能力，以解决一个主要目标 未来的协作精确网络，并制定研究框架和策略来支持 研究，协作研究项目和站点之间的协调。特定目标1。进行 多收到的方法来确定需求和当前可用资源的前瞻性和 有效地测量RA和SLE中的释放组（通过景观分析）。特定目标2。设计一个 前瞻性研究，以研究杂物体在RA和SLE病因中的作用，并具有跨学科 研究团队，严格的释放式测量和新颖的分析方法。