CHRONIC PROSTATITIS COLLABORATIVE CLINICAL RESEARCH

描述(摘自申请人的摘要) 慢性前列腺炎/慢性盆腔疼痛综合征(CPPS)影响所有男性 年龄。细胞因子是重要的炎症介质。我们已经展示了一个 白介素1-β水平与白介素1-β水平呈正相关 (IL-1-β)和白细胞。此外，IL-1-β水平 男性前列腺癌患者前列腺液(EPS)表达水平显著升高 炎症性CPPS高于对照组。 具体目的是调查： 1.CPPS中的细胞因子。我们将检验这样的假设，即细胞因子 通过检测IL-1-β、TNF-α(肿瘤坏死)在CPPS中的重要作用 前列腺液和前列腺组织中α-因子、IL-6和IL-8的表达 有CPPS的男人。我们将细胞因子水平、症状、尿动力学 发现，以及对行为修改和利用的响应，以 对患者进行分类，确定抗细胞因子治疗的作用。 2.感染源和CPPS。我们将检验这一假设 在使用rRNA探针和聚合酶的CPPS中，感染性因素是重要的 链式反应(PCR)以寻找挑剔的细菌和 慢性前列腺炎患者前列腺活检标本中的病毒。我们将决定 与炎症性CPPS相关的生物体是否与 与非炎症性CPPS相关，并将这些发现与 细胞因子的存在。这些发现将提供重要的新见解 探讨CPPS的发病机制，并允许潜能的开发 CPPS的抗菌治疗。 3.排尿功能障碍/生物反馈与CPPS。我们将测试 假设患有CPPS的男性有排尿功能障碍和症状 可以通过生物反馈来改善。男性将随机接受生物反馈 或者没有生物反馈。这项研究将提供对人际关系的洞察 CPPS之间、临床指征对尿流动力学的评价 以及这些患者对行为改变的反应。 4A.生物反馈治疗的有效性。我们将检验这一假设 接受生物反馈治疗的患者将会有更好的结果 以健康状况、症状的减轻或改善来衡量 功能状态，生活质量的改善，以及减少 通过就诊、测试和接触来衡量医疗保健利用率。 符合成本效益护理的诊断、管理和治疗途径 有CPPS的男人。 这一项目将为深入了解其发病机制和机制提供重要的新见解。 对患有CPPS的男性的管理。

DESCRIPTION (Taken from the applicant's Abstract) Chronic Prostatitis/Chronic Pelvic Pain Syndrome (CPPS) affects men of all ages. Cytokines are important inflammatory mediators. We have shown a direct significant correlation between the levels of interleukin-1-beta (IL-1-beta) and white blood cells. Furthermore IL-1-beta levels were significantly higher in expressed prostatic secretion (EPS) of men with inflammatory CPPS than in controls. The specific aims are to investigate: 1. Cytokines in CPPS. We will test the hypothesis that cytokines are important in CPPS by measuring IL-1-beta, TNF-alfa (tumor necrosis factor-alpha), IL-6, and IL-8 in EPS and prostate tissue collected from 150 men with CPPS. We will correlate cytokine levels, symptoms, urodynamic findings, and response to behavioral modification and utilization, to classify patients and to determine the role of anticytokine therapy. 2. Infectious agents and CPPS. We will test the hypothesis that infectious agents are important in CPPS using rRNA probes and polymerase chain reaction (PCR) to search for the presence of fastidious bacteria and viruses in prostate biopsy specimens from men with CPPS. We will determine whether the organisms associated with inflammatory CPPS differ from those associated with noninflammatory CPPS and correlate these finding with the presence of cytokines. These findings will provide important new insights into the pathogenesis of CPPS and allow the development of potential antimicrobial therapy for CPPS. 3. Voiding Dysfunction/Biofeedback and CPPS. We will test the hypothesis that men with CPPS have dysfunctional voiding and that symptoms can be improved through biofeedback. Men will be randomized to biofeedback or no biofeedback. This study will provide insight into relationships between CPPS, the clinical indications for urodynamics in evaluating patients, and response to behavioral modification in these patients. 4a. Effectiveness of biofeedback treatment. We will test the hypothesis that patients who receive biofeedback treatment will have better outcomes as measured by health status, a reduction in symptoms or an improvement in functional status, an improvement of quality of life, and a reduction in healthcare utilization as measured by visits, tests, and contacts. diagnostic, management, and treatment pathways for cost-effective care for men with CPPS. This project will provide important new insights into the pathogenesis and management of men with CPPS.