PARAHIPPOCAMPAL REGION--BASIC AND CLINICAL IMPLICATIONS

描述(改编自申请者摘要)：纽约学院 《科学》杂志正在主办一场名为《海马区旁：基础》的会议。 “科学与临床的影响”，1999年9月在华盛顿特区。 首席研究员兼主席是海伦·沙夫曼博士，系主任， 海伦·海斯医院神经病学研究中心，助理教授， 哥伦比亚大学药理学和神经病学系。联席轮椅 曼诺·威特博士，弗里耶大学解剖学系教授， 荷兰和罗伯特·施瓦茨博士，神经科学项目负责人， 马里兰精神病学研究中心，精神病学系教授 马里兰大学药理学专业。 颞叶中的几个结构在大脑中起着关键作用 功能，如学习和记忆、情绪和复杂的行为 流程。其中包括最常被研究的结构--海马体 在颞叶和并列的海马旁区域，这是 由内嗅皮层、周围皮质和海马旁皮质组成。 在过去的十年里，病态的 海马区的变化发生在几个 灾难性的神经和精神疾病，如阿尔茨海默氏症 疾病、精神分裂症和癫痫。因此，很有可能 海马区旁的神经病理导致了这些患者的功能障碍，也许 其他脑部疾病。值得注意的是，海马区的病理可能是 其中几种疾病的关键因素，无论 海马体本身。 这次会议的目的是将过去的研究与最新信息结合起来 关于海马区的结构和功能。经常性的 主题将是使用这些信息来推进诊断和 治疗使人衰弱的脑部疾病。解剖学，生物化学， 两种实验动物的生理、行为和病理学研究 人类将被该领域的领导者描述，并将提供一种 对大脑的这一重要部分进行全面、最新的回顾。 这些演讲将针对广泛的基础和临床 提供给研究人员和临床从业者。我们将特别强调 吸引妇女和少数群体，并在广泛范围内包括个人 受教育程度。如此多样化的受众将提供最佳的 交流思想的机会，从而确保一个充满活力和 刺激的氛围，在这种氛围中，激动人心的新概念和假设可以 已生成。

DESCRIPTION (Adapted from applicant's abstract): The New York Academy of Science is sponsoring a conference entitled: "The Parahippocampal Region: Basic Science and Clinical Implications" in Washington, D.C. in September, 1999. The principal investigator and chair is Helen Scharfman, Ph.D., Department Head, Neurology Research Center, Helen Hayes Hospital and Assistant Professor, Departments of Pharmacology and Neurology, Columbia University. The cochairs are Menno Witter PhD., Professor, Department of Anatomy, Vrije Universiteit, The Netherlands and Robert Schwarcz, Ph.D., Head, Neuroscience Program, Maryland Psychiatric Research Center, and Professor, Departments of Psychiatry and Pharmacology, University of Maryland. Several structures in the temporal lobe play a critical role in brain functions, such as learning and memory, emotions, and complex behavioral processes. These include the hippocampus, the most frequently studied structure in the temporal lobe, and the juxtaposed parahippocampal region, which is comprised of the entorhinal cortex, perirhinal, and parahippocampal cortex. During the last decade, it has become increasingly clear that pathological changes in the parahippocampal region occur during the early stages of several catastrophic neurological and psychiatric diseases, such as Alzheimer's disease, schizophrenia, and epilepsy. Thus, it is quite likely that parahippocampal neuropathology contributes to dysfunction in these, and perhaps other brain disorders. Notably, pathology in the parahippocampal region may be a critical element of several of these diseases, regardless of the state of the hippocampus proper. This meeting is intended to integrate past studies with the latest information about the structure and function of the parahippocampal region. A recurrent theme will be the use of this information to advance the diagnosis and treatment of debilitating brain disorders. Anatomical, biochemical, physiological, behavioral, and pathological studies in both laboratory animals and humans will be described by the leaders in the field, and will provide a comprehensive, up-to-date review of this important part of the brain. The presentations will be targeted to a wide range of basic and clinical researchers and to clinical practitioners. Special emphasis will be placed on attracting women and minorities, and on including individuals at a wide range of educational levels. Such a diverse audience will provide optimal opportunities for cross-fertilization of ideas, and thus ensure a dynamic and stimulating atmosphere, in which exciting new concepts and hypotheses can be generated.