Postdoctoral Research Training in Neurodegenerative Disorders and the Aging Brain

项目摘要 这项培训资助申请建议集中培训对 在纽约大学朗格尼医学中心(NYULMC)从事脑老化和神经退行性疾病的职业生涯。有一个 迫切需要培训下一代医学和博士研究人员来调查脑部疾病的原因 衰老，开发新的治疗方法和干预措施，并将这些发现从长凳上翻译到床边 从床边到社区。本申请旨在选出四名优秀的博士后实习生 从一批合格的医学博士和博士申请者中，开发和实施全面的课程和 提供为期两年的基础、翻译、临床和心理社会研究方面的高质量研究培训。这 培训计划，以认知神经学中心(CCN)为中心，这是一个全校、系外、 旨在促进合作、翻译研究的多学科计划。CCN将作为 统一的保护伞，在此基础上，该计划将得到实施、持续和财政支持，同时 提供确保成功的基础设施，并为学员提供“社区意识”和 在NYULMC内的总部。未来对具有良好记录的高技能调查人员的需求 检查大脑老化和神经退行性疾病将是与衰老相关的神经退行性疾病 随着人口老龄化，疾病继续增加。培养下一代研究人员 在这些疾病方面有专长的科学家和研究临床医生现在和将来仍然是公共卫生的优先事项。 美国在未来的许多年里。医学研究所认识到青少年的匮乏。 在老年病学和老年学方面具有专业知识的研究人员和临床医生。到目前为止，这些呼吁增加了 进入老龄化调查一直没有得到答复。因此，存在一个强有力的、令人信服的理由来 巩固和扩大脑老化和神经退行性疾病的研究-培训计划 通过T32培训计划的支持。为此，我们提出了以下具体目标：1.发展 为博士后提供脑老化和神经退行性变领域的研究培训机会 对学员进行脑老化和神经退行性疾病的基础知识教育，严谨的研究 方法论、临床方法、统计分析和负责任的研究行为原则； 3.为临床提供一个互动、协作的环境，促进个人和职业成长， 心理社会、翻译和基础科学实习生；以及4.提高实习生的必备技能 以K-和R-奖形式提供的外部资金。

Project Summary This training grant application proposes the centralization of training postdoctoral candidates interested in a career in brain aging and neurodegenerative disease at NYU Langone Medical Center (NYULMC). There is a critical need to train the next generation of MD and PhD researchers to investigate causes of disorders of brain aging, develop new therapeutics and interventions, and translate these findings from bench to bedside as well as from bedside to community. This application is designed to select four outstanding postdoctoral trainees from a well qualified pool of MD and PhD applicants, develop and implement a comprehensive curriculum and provide 2-years of high quality research training in basic, translational, clinical, and psychosocial research. This Training Program, centered in the Center for Cognitive Neurology (CCN), a school-wide, extradepartmental, multidisciplinary program designed to foster collaborative, translational research. The CCN will serve as the unifying umbrella under which this program will be implemented, sustained and financially supported while providing the infrastructure to guarantee success and supplying the trainees a “sense of community” and a home-base within NYULMC. The future demand for highly skilled investigators with a proven track-record examining brain aging and neurodegenerative diseases will be substantial as aging-related neurodegenerative disorders continue to increase with an aging population. The training of the next generation of research scientists and research clinicians with expertise in these diseases is and will remain a public health priority in the United States for many years to come. The Institute on Medicine recognized the dearth of junior investigators and clinicians with expertise in geriatrics and gerontology. To date, these calls for increased entrance into aging investigation have been left unanswered. Thus, a strong and compelling rationale exists to consolidate and expand the research-training program for brain aging and neurodegenerative disorders through the support of a T32 training program. To do this we propose the following Specific Aims: 1. Develop research training opportunities for postdoctoral candidates in the area of brain aging and neurodegenerative disease; 2. Educate trainees to fundamentals of brain aging and neurodegenerative disease, rigorous research methodology, clinical approaches, statistical analyses, and the principles of responsible conduct of research.; 3. Provide an interactive, collaborative environment fostering personal and professional growth for clinical, psychosocial, translational and basic science trainees.; and 4. Enhance trainees' requisite skills to gain external funding in the form of K- and R- awards.