Postdoctoral Research Training in Neurodegenerative Disorders and the Aging Brain

项目摘要 这项培训补助金申请提出了集中培训博士后候选人感兴趣的一个 在纽约大学Langone医学中心（NYULMC）从事脑老化和神经退行性疾病的研究。有一个 迫切需要培养下一代医学博士和博士研究人员调查大脑疾病的原因 衰老，开发新的治疗方法和干预措施，并将这些发现从实验室转化为床边，以及 从床边到社区。本次申报旨在选拔四名优秀博士后 从一个合格的MD和博士申请人池，开发和实施全面的课程， 提供2年的基础，转化，临床和心理社会研究的高质量研究培训。这 培训计划，以认知神经病学中心（CCN）为中心，这是一个全校性的，跨部门的， 旨在促进协作、转化研究的多学科计划。CCN将作为 统一的伞下，该计划将得到实施，持续和财政支持， 提供基础设施，以保证成功，并提供学员的“社区意识”和 在纽约大学医学中心的基地未来对高技能调查人员的需求， 检查大脑老化和神经退行性疾病将是实质性的， 随着人口老龄化，疾病继续增加。培养下一代研究人员 在这些疾病方面具有专业知识的科学家和临床研究人员是并将继续是公共卫生的优先事项， 美国在未来几年。医学研究所认识到年轻人的缺乏 具有老年医学和老年学专业知识的研究人员和临床医生。到目前为止，这些呼吁增加了 进入老龄化调查一直没有答案。因此，有一个强有力的理由， 巩固和扩大脑老化和神经退行性疾病的研究培训计划 通过T32培训计划的支持。为此，我们提出以下具体目标：1.发展 为脑老化和神经退行性疾病领域的博士后候选人提供研究培训机会 疾病; 2。教育受训人员了解大脑老化和神经退行性疾病的基本知识，严格的研究 方法学、临床方法、统计分析和负责任的研究原则。 3.提供一个互动，协作的环境，促进个人和专业成长的临床， 社会心理学、翻译学和基础科学的受训者。和4.提高学员的必备技能， 以K-和R-奖项形式提供外部资金。

Project Summary This training grant application proposes the centralization of training postdoctoral candidates interested in a career in brain aging and neurodegenerative disease at NYU Langone Medical Center (NYULMC). There is a critical need to train the next generation of MD and PhD researchers to investigate causes of disorders of brain aging, develop new therapeutics and interventions, and translate these findings from bench to bedside as well as from bedside to community. This application is designed to select four outstanding postdoctoral trainees from a well qualified pool of MD and PhD applicants, develop and implement a comprehensive curriculum and provide 2-years of high quality research training in basic, translational, clinical, and psychosocial research. This Training Program, centered in the Center for Cognitive Neurology (CCN), a school-wide, extradepartmental, multidisciplinary program designed to foster collaborative, translational research. The CCN will serve as the unifying umbrella under which this program will be implemented, sustained and financially supported while providing the infrastructure to guarantee success and supplying the trainees a “sense of community” and a home-base within NYULMC. The future demand for highly skilled investigators with a proven track-record examining brain aging and neurodegenerative diseases will be substantial as aging-related neurodegenerative disorders continue to increase with an aging population. The training of the next generation of research scientists and research clinicians with expertise in these diseases is and will remain a public health priority in the United States for many years to come. The Institute on Medicine recognized the dearth of junior investigators and clinicians with expertise in geriatrics and gerontology. To date, these calls for increased entrance into aging investigation have been left unanswered. Thus, a strong and compelling rationale exists to consolidate and expand the research-training program for brain aging and neurodegenerative disorders through the support of a T32 training program. To do this we propose the following Specific Aims: 1. Develop research training opportunities for postdoctoral candidates in the area of brain aging and neurodegenerative disease; 2. Educate trainees to fundamentals of brain aging and neurodegenerative disease, rigorous research methodology, clinical approaches, statistical analyses, and the principles of responsible conduct of research.; 3. Provide an interactive, collaborative environment fostering personal and professional growth for clinical, psychosocial, translational and basic science trainees.; and 4. Enhance trainees' requisite skills to gain external funding in the form of K- and R- awards.