EUKARYOTIC MRNA PROCESSING CONFERENCE

拟议的“真核mRNA加工”会议：将召集科学家研究mRNA剪接和3 '端加工机制的各个方面，并在高等真核生物和酵母中进行调控。最近在这些领域取得了重大进展，拟议的会议将是一个及时的事件，讨论最新的未发表的结果和交流思想，治疗促进这一迅速发展的领域的新发展。拟议的会议将于1999年8月25日至29日举行，是每隔一年在冷泉港实验室举行的会议的第二次会议。第一次会议于1997年8月20日至24日举行，吸引了272名国际科学家，他们正在积极研究信使RNA成熟的各个方面，特别是mRNA剪接和聚腺苷酸化，但范围现在将略有扩大，包括核mRNA编辑。会议形式将包括七次全体会议和三次海报会议。将根据提交的摘要挑选全体会议的发言者，这将鼓励年轻科学家积极参与。主要内容包括：mRNA剪接和3 '端加工的催化机制和特异性：通过选择性剪接和多聚腺苷酸化对基因表达的发育和细胞类型特异性调节; snRNP颗粒和hnRNP，SR蛋白，PRPs和其他酵母，后生动物和/或植物蛋白因子参与多聚腺苷酸化剪接的结构和功能;剪接体组装;核mRNA编辑; mRNA周转;以及加工反应、因子、底物和产物的定位和动力学，与核结构和核质运输有关。

The proposed conference on "Eukaryotic mRNA Processing": will convene scientists studying various aspects of mRNA splicing and 3'-end processing mechanisms and regulation in higher eucaryote and in yeast. Major advances have recently been made in these areas, and the proposed conference will be a timely event for discussing the latest unpublished results and exchanging idea, therapy fostering new developments in this rapidly moving field. The proposed conference will be held on August 25-29, 199 and is the second meeting of a conference that is held every other year at Cold Spring Harbor Laboratory. The first meeting was held on August 20-24, 1997, and attracted 272 scientists internationally, who are actively investigating various aspects of messenger RNA maturation, particularly mRNA splicing and polyadenylation, but the scope will now be slight expanding to encompass nuclear mRNA editing. The meeting format will consist of seven plenary sessions and three poster sessions. Speakers in the plenary sessions will be will be selected on the basis of the submitted abstracts which will encourage active participation by junior scientists. The main topics covered will include: catalytic mechanisms and specificity of mRNA splicing and 3'-end processing: developmental and cell-type specific regulation of gene expression by alterative splicing and polyadenylation; structure and function of snRNP particles and of hnRNPs, SR proteins, PRPs, and other yeast, metazoan, and/or plant protein factors involved in splicing of polyadenylation; spliceosome assembly; nuclear mRNA editing; mRNA turnover; and localization and dynamics of processing reactions, factors, substrates, and products, in relation to nuclear architecture and to nuclear- cytoplasmic transport.