2008 The Biology of Post-Transcriptional Gene Regulation Gordon Research Conferen

2008 转录后基因调控生物学戈登研究会议

• 批准号: 7476630
• 负责人: Adrian R Krainer
• 金额: $ 1万
• 依托单位: GORDON RESEARCH CONFERENCES
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-04-01 至 2009-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7476630
• 关键词: Address; Area; Biogenesis; Biology; Catalysis; Coupling; Defect; Disease; Evolution; Fertilization; Functional RNA; Functional disorder; Gene Expression Regulation; Genetic Transcription; Genomics; Goals; Health; Hereditary Disease; Human; Human Genome; Learning; Maine; Malignant Neoplasms; Mediating; Messenger RNA; Metabolism; MicroRNAs; Neurologic; Neuromuscular Diseases; Participant; Principal Investigator; Public Health; RNA; RNA Processing; RNA Splicing; RNA Transport; Regulation; Request for Proposals; Research; Research Personnel; Series; Signal Transduction; Students; Transfer RNA; Translations; college; day; improved; interest; mRNA Decay; posters; programs; symposium

DESCRIPTION (provided by applicant): This proposal requests partial support for a Gordon Research Conference on The Biology of Post-Transcriptional Gene Regulation, to be held at Colby College in Waterville, Maine, from June 29 to July 4, 2008. This meeting is the third one of a Gordon Conference series held every other year. The broad and long-term goal of the conference is to improve our current understanding of fundamental mechanisms and regulation of RNA biogenesis in normal and disease states. The emphasis is on post- transcriptional transactions involving mRNA, but this extends to transcriptional coupling, and to factors involved in translation and its control, including tRNA and microRNAs. The specific aims of this meeting will be to convene approximately 45 speakers representing key areas of post-transcriptional gene regulation, with a total of 150 participants, for a five-day meeting. The program will consist of nine morning or evening sessions that will broadly address cutting-edge issues in: coupling between transcription and RNA processing; genomics and evolution of RNA-processing signals and factors; RNA splicing catalysis, fidelity, regulation, and involvement in disease; RNA turnover, including nonsense-mediated mRNA decay; RNA transport and localization; non-coding RNA; and translational control. In addition, small poster sessions on four late afternoons will enable all participants to contribute to, and learn about, these topics. Free early- afternoon and late-evening periods in the relatively isolated summer setting of Colby College will stimulate productive, informal discussions among established and junior principal investigators, postdoctoral trainees and graduate students from the U.S. and abroad. The significance of this application is that this GRC has a unique format and brings together sets of researchers who, despite having converging interests, have infrequent opportunities to meet as a group. The resulting discussions and cross- fertilization will help define critical areas to propel this field forward. In addition, elucidating the basic mechanisms of post-transcriptional gene regulation will be essential to gain a full understanding of the organization, function, and evolution of the human genome. The health relatedness of this application reflects the extensive involvement of RNA-processing dysfunction in numerous genetic diseases, neurological and neuromuscular disorders, and cancer. PUBLIC HEALTH RELEVANCE The relevance of this application to public health reflects the extensive involvement of defects in RNA metabolism associated with many human genetic diseases, neurological and neuromuscular disorders, and cancer. In addition, elucidating the basic mechanisms of the steps of gene regulation that are the focus of this conference, will be essential to gain a full understanding of the organization, function, and evolution of the human genome.

描述(由申请人提供)：本提案请求部分支持将于2008年6月29日至7月4日在缅因州沃特维尔的科尔比学院举行的戈登转录后基因调控生物学研究会议。这次会议是戈登会议系列会议中的第三次，每隔一年举行一次。会议的广泛和长期目标是提高我们目前对正常和疾病状态下RNA生物发生的基本机制和调控的理解。重点是涉及mRNA的转录后交易，但这延伸到转录耦合，以及参与翻译及其控制的因素，包括tRNA和microRNAs。这次会议的具体目标是召集大约45名发言者，代表转录后基因调控的关键领域，总共150名与会者，为期五天的会议。该计划将由九个上午或晚间会议组成，将广泛讨论以下前沿问题：转录和RNA加工之间的耦合；基因组学和RNA加工信号和因子的进化；RNA剪接催化、保真度、调节和与疾病的参与；RNA周转，包括无意义介导的mRNA衰变；RNA运输和定位；非编码RNA；以及翻译控制。此外，在四个下午晚些时候举行的小型海报会议将使所有参与者能够为这些主题做出贡献并了解这些主题。在科尔比学院相对与世隔绝的夏季环境中，自由的下午早些时候和晚上的时间将鼓励来自美国和海外的知名和初级主要研究人员、博士后实习生和研究生之间进行富有成效的非正式讨论。这个应用程序的意义在于，这个GRC有一个独特的形式，并将几组研究人员聚集在一起，尽管他们有共同的兴趣，但很少有机会作为一个小组见面。由此产生的讨论和相互促进将有助于确定推动这一领域向前发展的关键领域。此外，阐明转录后基因调控的基本机制对于全面了解人类基因组的组织、功能和进化至关重要。这一应用的健康相关性反映了RNA加工功能障碍在许多遗传性疾病、神经和神经肌肉疾病以及癌症中的广泛参与。公共卫生相关性这项应用与公共卫生的相关性反映了与许多人类遗传病、神经和神经肌肉疾病以及癌症相关的RNA代谢缺陷的广泛参与。此外，阐明作为本次会议焦点的基因调控步骤的基本机制，对于全面了解人类基因组的组织、功能和进化将是至关重要的。