LIPIDS AS MODULATORS OF GENE EXPRESSION
脂质作为基因表达的调节剂
基本信息
- 批准号:2884171
- 负责人:
- 金额:$ 1.5万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:1999
- 资助国家:美国
- 起止时间:1999-06-01 至 2000-05-31
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
DESCRIPTION (adapted from the applicant's abstract): It is known that specific
lipids and their metabolites control the transcription of genes and mediate
diverse aspects of intracellular signaling. Recent advances have defined the
signaling molecule's transcription factors, auxiliary coactivators and
corepressors and the mechanisms through which these factors act to regulate the
expression of genes. These new insights may help to further our understanding
of both normal physiological homeostatic control, i.e., cholesterol homeostasis
mediated by feedback regulation through sterol-responsive element binding
proteins (SREBPs) and the bases for certain pathophysiological states such as
diabetes from insulin resistance and the role of peroxisomal proliferator
activator receptor in this disease, also known as PPAR GAMMA. The opportunity
to discover new therapeutics for the treatment of diseases caused by altered
lipid metabolism, specifically hyperlipidemia, atherosclerosis, diabetes,
obesity, and neurological disease has been realized by scientists working in
research programs in academia and in industry.
The function of this application is to provide support for the 1999 Kern Aspen
Lipid Conference entitled "Lipids as Modulators of Gene Expression: Lipid
Metabolism and Atherosclerosis." The goal of this is to present and discuss new
findings in the area of transcriptional regulation of lipid metabolizing genes.
The meeting is designed to allow for intensive didactic presentations and
extensive interaction periods. Both directly following each presentation and
during lunches and poster sessions the meeting will begin on Saturday afternoon
and end mid-day Tuesday. A typical day's activities will include a four- to
five-hour session with four speakers; each speaker will present for 30 minutes
and then lead a discussion of 30 minutes. On Sunday a two-hour poster session
is scheduled after lunch. Each poster session has 20 posters which will be
presented by young investigators. One informal buffet dinner is held on Sunday
evening to further allow for discussions between attendees. A brief summary of
the meeting generally appears in the Journal of Lipid Research. The chairmen of
the meeting are Roger Davis of San Diego State University and David Russell of
the University of Texas SW Medical Center.
Session I is transcriptional regulation of lipid metabolism; Session II is
cellular signaling, gene expression and intracellular trafficking; Session III
is the role of PPARgamma in lipid metabolism; and Session IV is gene expression
in macrophages in the arterial wall.
Session I will be moderated by Roger Davis, and speakers will be Joseph
Goldstein, David Mangelsdorf, Bob Tjian, and H.S. Sul. The moderator is Session
II will be David Russell, and speakers will be Phil Beachy, Thomas Sudhof, and
Tom Innerarity. Session III will be moderated by Helen Hobbs; speakers will be
Ron Evans, Chris Glass, Mike Milburn, and Helen Hobbs. Session IV will be
moderated by Linda Curtiss and speakers will be Peter Edwards, Peter Libby,
Steve Prescott, and Zena Werb. There will be an additional four oral sessions
and two poster sessions.
描述(改编自申请人的摘要):我们知道,具体的
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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ROGER A DAVIS其他文献
ROGER A DAVIS的其他文献
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{{ truncateString('ROGER A DAVIS', 18)}}的其他基金
Agilent 6890 GC/5973 mass detector for Profiling
用于分析的 Agilent 6890 GC/5973 质量检测器
- 批准号:
6877331 - 财政年份:2005
- 资助金额:
$ 1.5万 - 项目类别:
Intervention of Atherogenesis by Gene Transfer
通过基因转移干预动脉粥样硬化形成
- 批准号:
6662021 - 财政年份:1997
- 资助金额:
$ 1.5万 - 项目类别:
INTERVENTION IN ATHEROGENESIS BY 7ALPHA HYDROXYLASE
7α 羟化酶干预动脉粥样硬化
- 批准号:
6183918 - 财政年份:1997
- 资助金额:
$ 1.5万 - 项目类别:
INTERVENTION IN ATHEROGENESIS BY 7ALPHA HYDROXYLASE
7α 羟化酶干预动脉粥样硬化
- 批准号:
2031188 - 财政年份:1997
- 资助金额:
$ 1.5万 - 项目类别:
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