LIPIDS AS MODULATORS OF GENE EXPRESSION

描述(改编自申请人的摘要)：已知具体情况 脂类及其代谢物控制基因转录并调节 细胞内信号的不同方面。最近的进展定义了 信号分子转录因子、辅助共激活因子和 辅抑制子和这些因子调节细胞周期的机制 基因的表达。这些新的见解可能有助于加深我们的理解 正常的生理平衡控制，也就是胆固醇平衡 通过类固醇反应元件结合进行反馈调节 蛋白质(SREBPs)和某些病理生理状态的基础，如 胰岛素抵抗所致糖尿病与过氧化物酶体增殖物的作用 激活剂受体在本病中也称为PPAR-γ。机遇 发现治疗由变态反应引起的疾病的新疗法 脂代谢，特别是高脂血症，动脉粥样硬化，糖尿病， 肥胖和神经疾病已经被科学家们认识到 学术界和工业界的研究计划。 此应用程序的功能是为1999年的Kern Aspen提供支持 脂类会议题为《作为基因表达调节剂的脂类：脂类 新陈代谢与动脉粥样硬化“的目标是提出和讨论新的 在脂类代谢基因转录调控领域的发现。 会议旨在允许密集的说教演示和 广泛的互动期。紧跟在每次演示之后和 在午餐和海报会议期间，会议将于周六下午开始 周二中午结束。典型的一天活动将包括四到四个小时 五个小时的会议，四位演讲者；每位演讲者演讲30分钟 然后引导一场30分钟的讨论。周日，为期两个小时的海报发布活动 安排在午餐后。每个海报环节有20张海报，将 由年轻的调查人员提交。周日举行一次非正式的自助晚餐。 晚上，与会者之间可以进一步进行讨论。简要总结一下 该会议一般发表在《脂质研究杂志》上。各委员会的主席 参加会议的是圣地亚哥州立大学的罗杰·戴维斯和加州大学的大卫·拉塞尔 德克萨斯大学西南医学中心。 第一节是脂代谢的转录调控；第二节是 细胞信号、基因表达和细胞内运输 是PPARGamma在脂类代谢中的作用；第四阶段是基因表达 在动脉壁的巨噬细胞中。 第一节由罗杰·戴维斯主持，约瑟夫担任演讲者。 书名/作者声明：//David Mangelsdorf/David Mangelsdorf；主持人是会议主持人 第二名将是大卫·拉塞尔，演讲者将是菲尔·比奇、托马斯·苏德霍夫和 汤姆·内纳利。第三节将由海伦·霍布斯主持；演讲者将是 罗恩·埃文斯、克里斯·格拉斯、迈克·米尔本和海伦·霍布斯。第四节课将是 由琳达·柯蒂斯主持，彼得·爱德华兹、彼得·利比、 史蒂夫·普雷斯科特和泽娜·韦伯。另外还会有四个口头会议 和两次海报会议。

DESCRIPTION (adapted from the applicant's abstract): It is known that specific lipids and their metabolites control the transcription of genes and mediate diverse aspects of intracellular signaling. Recent advances have defined the signaling molecule's transcription factors, auxiliary coactivators and corepressors and the mechanisms through which these factors act to regulate the expression of genes. These new insights may help to further our understanding of both normal physiological homeostatic control, i.e., cholesterol homeostasis mediated by feedback regulation through sterol-responsive element binding proteins (SREBPs) and the bases for certain pathophysiological states such as diabetes from insulin resistance and the role of peroxisomal proliferator activator receptor in this disease, also known as PPAR GAMMA. The opportunity to discover new therapeutics for the treatment of diseases caused by altered lipid metabolism, specifically hyperlipidemia, atherosclerosis, diabetes, obesity, and neurological disease has been realized by scientists working in research programs in academia and in industry. The function of this application is to provide support for the 1999 Kern Aspen Lipid Conference entitled "Lipids as Modulators of Gene Expression: Lipid Metabolism and Atherosclerosis." The goal of this is to present and discuss new findings in the area of transcriptional regulation of lipid metabolizing genes. The meeting is designed to allow for intensive didactic presentations and extensive interaction periods. Both directly following each presentation and during lunches and poster sessions the meeting will begin on Saturday afternoon and end mid-day Tuesday. A typical day's activities will include a four- to five-hour session with four speakers; each speaker will present for 30 minutes and then lead a discussion of 30 minutes. On Sunday a two-hour poster session is scheduled after lunch. Each poster session has 20 posters which will be presented by young investigators. One informal buffet dinner is held on Sunday evening to further allow for discussions between attendees. A brief summary of the meeting generally appears in the Journal of Lipid Research. The chairmen of the meeting are Roger Davis of San Diego State University and David Russell of the University of Texas SW Medical Center. Session I is transcriptional regulation of lipid metabolism; Session II is cellular signaling, gene expression and intracellular trafficking; Session III is the role of PPARgamma in lipid metabolism; and Session IV is gene expression in macrophages in the arterial wall. Session I will be moderated by Roger Davis, and speakers will be Joseph Goldstein, David Mangelsdorf, Bob Tjian, and H.S. Sul. The moderator is Session II will be David Russell, and speakers will be Phil Beachy, Thomas Sudhof, and Tom Innerarity. Session III will be moderated by Helen Hobbs; speakers will be Ron Evans, Chris Glass, Mike Milburn, and Helen Hobbs. Session IV will be moderated by Linda Curtiss and speakers will be Peter Edwards, Peter Libby, Steve Prescott, and Zena Werb. There will be an additional four oral sessions and two poster sessions.