LIPIDS AS MODULATORS OF GENE EXPRESSION

脂质作为基因表达的调节剂

• 批准号: 2884171
• 负责人: ROGER A DAVIS
• 金额: $ 1.5万
• 依托单位: SAN DIEGO STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-06-01 至 2000-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2884171
• 关键词: gene expression; lipids; meeting /conference /symposium; travel

DESCRIPTION (adapted from the applicant's abstract): It is known that specific lipids and their metabolites control the transcription of genes and mediate diverse aspects of intracellular signaling. Recent advances have defined the signaling molecule's transcription factors, auxiliary coactivators and corepressors and the mechanisms through which these factors act to regulate the expression of genes. These new insights may help to further our understanding of both normal physiological homeostatic control, i.e., cholesterol homeostasis mediated by feedback regulation through sterol-responsive element binding proteins (SREBPs) and the bases for certain pathophysiological states such as diabetes from insulin resistance and the role of peroxisomal proliferator activator receptor in this disease, also known as PPAR GAMMA. The opportunity to discover new therapeutics for the treatment of diseases caused by altered lipid metabolism, specifically hyperlipidemia, atherosclerosis, diabetes, obesity, and neurological disease has been realized by scientists working in research programs in academia and in industry. The function of this application is to provide support for the 1999 Kern Aspen Lipid Conference entitled "Lipids as Modulators of Gene Expression: Lipid Metabolism and Atherosclerosis." The goal of this is to present and discuss new findings in the area of transcriptional regulation of lipid metabolizing genes. The meeting is designed to allow for intensive didactic presentations and extensive interaction periods. Both directly following each presentation and during lunches and poster sessions the meeting will begin on Saturday afternoon and end mid-day Tuesday. A typical day's activities will include a four- to five-hour session with four speakers; each speaker will present for 30 minutes and then lead a discussion of 30 minutes. On Sunday a two-hour poster session is scheduled after lunch. Each poster session has 20 posters which will be presented by young investigators. One informal buffet dinner is held on Sunday evening to further allow for discussions between attendees. A brief summary of the meeting generally appears in the Journal of Lipid Research. The chairmen of the meeting are Roger Davis of San Diego State University and David Russell of the University of Texas SW Medical Center. Session I is transcriptional regulation of lipid metabolism; Session II is cellular signaling, gene expression and intracellular trafficking; Session III is the role of PPARgamma in lipid metabolism; and Session IV is gene expression in macrophages in the arterial wall. Session I will be moderated by Roger Davis, and speakers will be Joseph Goldstein, David Mangelsdorf, Bob Tjian, and H.S. Sul. The moderator is Session II will be David Russell, and speakers will be Phil Beachy, Thomas Sudhof, and Tom Innerarity. Session III will be moderated by Helen Hobbs; speakers will be Ron Evans, Chris Glass, Mike Milburn, and Helen Hobbs. Session IV will be moderated by Linda Curtiss and speakers will be Peter Edwards, Peter Libby, Steve Prescott, and Zena Werb. There will be an additional four oral sessions and two poster sessions.

描述（改编自申请人的摘要）：已知特定的 脂质及其代谢产物控制基因的转录， 细胞内信号的不同方面。最近的进展已经定义了 信号分子的转录因子、辅助共激活因子和 辅阻遏物和这些因子调节细胞凋亡的机制 基因的表达。这些新的见解可能有助于我们进一步了解 正常的生理自我平衡控制，即，胆固醇稳态 通过甾醇反应元件结合的反馈调节介导 蛋白质（SREBPs）和某些病理生理状态的基础， 糖尿病与胰岛素抵抗及过氧化物酶体增殖物的关系 这种疾病中的激活受体，也称为PPAR γ。机会 发现新的治疗方法，用于治疗由改变的 脂质代谢，特别是高脂血症，动脉粥样硬化，糖尿病， 肥胖和神经系统疾病已经被科学家们意识到， 学术界和工业界的研究项目。 此应用程序的功能是为1999年克恩白杨提供支持 脂质会议，题为“脂质作为基因表达的调节剂：脂质 代谢和动脉粥样硬化。“这样做的目标是提出和讨论新的 在脂质代谢基因转录调控领域的发现。 会议旨在进行密集的教学介绍， 广泛的互动期。在每次演讲之后， 在午餐和海报会议期间，会议将于周六下午开始 周二中午结束一个典型的一天的活动将包括一个四到 5小时会议，4位发言人;每位发言人将发言30分钟 然后进行30分钟的讨论。星期天，两个小时的海报会议 安排在午饭后每一个海报展览会有20张海报， 由年轻的研究人员提出。周日提供一次非正式自助晚餐 晚上，让与会者进一步讨论。的简要总结 该会议通常发表在《脂质研究杂志》上。的主席 参加会议的是圣地亚哥州立大学的罗杰·戴维斯和圣地亚哥大学的大卫·拉塞尔。 德克萨斯大学西南医学中心 第一部分是脂质代谢的转录调控;第二部分是 细胞信号传导、基因表达和细胞内运输 是PPARgamma在脂质代谢中的作用;第四部分是基因表达 动脉壁的巨噬细胞。 第一次会议将由罗杰戴维斯主持，发言人将是约瑟夫 Goldstein，大卫Mangelsdorf，Bob Tjian，和H.S.南主持人是会话 II将是大卫罗素，演讲者将是菲尔比奇，托马斯Sudhof， 汤姆·内纳瑞蒂第三场会议将由Helen Hobbs主持;发言者包括： 罗恩埃文斯，克里斯格拉斯，迈克米尔本，和海伦霍布斯。第四次会议将是 由琳达柯蒂斯主持，发言人将是彼得爱德华兹，彼得利比， 史蒂夫·普雷斯科特和泽娜·韦伯将有额外的四个口头会议 和两个海报会议。