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RECEPTORS FOR ABUSED DRUGS--DEVELOPMENT AND PLASTICITY

滥用药物的受体——发育和可塑性

基本信息

批准号：
2835535
负责人：
JERROLD S MEYER
金额：
$ 0.62万
依托单位：
NEUROBEHAVIORAL TERATOLOGY SOCIETY
依托单位国家：
美国
项目类别：
财政年份：
1999
资助国家：
美国
起止时间：
1999-06-01 至 1999-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/2835535
关键词：
amphetamines cannabinoid receptor cocaine developmental neurobiology drug abuse drug receptors growth /development meeting /conference /symposium neural plasticity nicotinic receptors phencyclidine protein localization protein structure function receptor expression

项目摘要

This application requests support for a Symposium entitled "Receptors for Abused Drugs: Development and Plasticity", to be part of the program at the Annual Meeting of the Neurobehavioral Teratology Society (NBTS). The meeting will take place at the Keystone Resort in Keystone, Colorado, from July 1 to July 4, 1999. The purpose of the proposed Symposium is to present the current state of knowledge concerning the normal ontogeny of receptors for several important drugs of abuse and how these receptors are altered by acute or chronic drug exposure during development. When ingested by pregnant women, abused drugs may adversely affect fetal neurobehavioral development by several mechanisms, including direct interaction with molecular targets (i.e., receptors) in the fetal brain. Thus, it is critically important for investigators studying prenatal drug effects in humans or in animal models to understand the normal localization and time course of receptor expression during development, as well as alterations in receptor expression (and their functional consequences) that occur following developmental drug exposure. The proposed Symposium will bring together five leading researchers, each of whom will cover one of receptor classes chosen for discussion. The speakers and their topics will be Dr. Theodore Slotkin, Duke University, who will discuss nicotine receptors, Dr. Frances Leslie, University of California at Irvine, who will discuss opiate receptors, Dr. Eva Mezey, National Institute on Neurological Diseases and Stroke, who will discuss cannabinoid receptors, Dr. Ratna Sircar, Albert Einstein College of Medicine, who will discuss phencyclidine (PCP) receptors, and Dr. Jerrold Meyer, University of Massachusetts, who will discuss monoamine transporters (the "receptors" for cocaine and amphetamine). Each speaker will discuss 1) the structure, function, and localization of his/her receptor(s), 2) normal receptor ontogeny (pre- and/or postnatal), and 3) receptor plasticity during development and the functional (i.e., behavioral or physiological) consequences of such plasticity. Alcohol will not be included in this Symposium, partly because there was a recent alcohol Symposium at NBTS and also because of the wide diversity of ion channels and other moieties thought to serve as the molecular targets of alcohol action in the brain. For the purpose of wider dissemination of the Symposium presentations, a summary of the proceedings jointly authored by all of the speakers will be published in Neurotoxicology and Teratology.

此应用程序请求支持名为“Receptors 滥用药物：发展和可塑性”，成为该计划的一部分神经行为畸形学学会（NBTS）年会。会议将在基斯通的基斯通度假村举行，科罗拉多，1999年7月1日至7月4日。建议的目的研讨会是为了介绍目前的知识状态，几种重要滥用药物受体的正常个体发育，这些受体如何被急性或慢性药物暴露改变，发展当孕妇摄入滥用药物时，对胎儿神经行为发育有不利影响，机制，包括与分子靶标的直接相互作用（即，受体）。因此，至关重要的是，研究产前药物对人类或动物影响的研究者了解受体的正常定位和时间过程的模型在发育过程中的表达，以及受体的改变，表达（及其功能后果）发生在发育期药物暴露拟议的研讨会将汇集五位主要研究人员，每人将涵盖一种受体，选择班级进行讨论。演讲者及其主题将是博士杜克大学的西奥多·斯洛特金将讨论尼古丁弗朗西斯莱斯利博士，加州大学欧文分校，谁将讨论阿片受体，伊娃梅齐博士，国家研究所对神经系统疾病和中风，谁将讨论大麻素 Ratna Sircar博士，阿尔伯特·爱因斯坦医学院，将讨论苯环利定（PCP）受体，和杰罗尔德迈耶博士，马萨诸塞州大学，将讨论单胺转运蛋白 (the可卡因和安非他明的“受体”）。每一位发言人将讨论1）他/她的结构、功能和定位受体，2）正常受体个体发育（出生前和/或出生后），和 3)发育过程中的受体可塑性和功能性（即，行为的或生理的）后果。醇将不包括在这次研讨会，部分原因是有一个最近的酒精研讨会在NBTS，也因为广泛的多样性离子通道和其他被认为是大脑中酒精作用的靶点。为了扩大传播专题讨论会的发言、由所有发言者共同撰写的会议记录将在神经毒理学和畸形学