All-optical manipulation and recording of neural circuit activity

全光学操纵和记录神经回路活动

• 批准号: LE180100012
• 负责人: Prof Gavan McNally
• 金额: $ 27.64万
• 依托单位: The University of New South Wales
• 依托单位国家: 澳大利亚
• 项目类别: Linkage Infrastructure, Equipment and Facilities
• 财政年份: 2018
• 资助国家: 澳大利亚
• 起止时间: 2018-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/LE180100012
• 关键词: optical; manipulation; recording; neural; circuit

This project aims to establish all-optical approaches to image and manipulate neural function at single cell resolution in the awake, freely moving animal. The project will help build a 'cells to systems' understanding of neural circuit function and aid in understanding neural circuit dysregulation in brain disorders. This will enable new, fundamental knowledge creation about brain function, and lay a basic science platform for the next generation of understanding of brain disorders, critical to reducing their economic burden.

该项目旨在建立全光学方法，以单细胞分辨率成像和操纵清醒，自由运动的动物的神经功能。该项目将有助于建立一个“细胞到系统”的神经回路功能的理解，并有助于理解大脑疾病中的神经回路失调。这将有助于创造关于大脑功能的新的基础知识，并为下一代理解大脑疾病奠定基础科学平台，这对减轻他们的经济负担至关重要。