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Pittsburgh Center for Kidney Research

匹兹堡肾脏研究中心

基本信息

批准号：
10747624
负责人：
Thomas R Kleyman
金额：
$ 96.98万
依托单位：
UNIVERSITY OF PITTSBURGH AT PITTSBURGH
依托单位国家：
美国
项目类别：
财政年份：
2023
资助国家：
美国
起止时间：
2023-09-01 至 2028-06-30
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10747624
关键词：
Acceleration Address Animals Area Biological Models Biology Biomedical Research Cell Culture Techniques Cells Cellular biology Collaborations Communities Complement Complex Core Facility Data Development Diet Disease Education Educational process of instructing Endocrine Ensure Epithelial Cells Equilibrium Equipment Event Faculty Fostering Friends Functional disorder Funding Goals Grant Health Homeostasis Human Image Imaging Device Imaging Techniques Individual Kidney Kidney Diseases Knowledge Manuscripts Modeling Molecular Nephrons Organ Organelles Organoids Pathway interactions Physiological Physiology Positioning Attribute Productivity Protocols documentation Pump Recording of previous events Regulation Renal function Research Research Activity Research Design Research Personnel Research Project Grants Resolution Resource Development Resources Role Scientist Signal Transduction Speed Students Sum Talents Training Tubular formation Universities Work Yeasts autocrine biomedical resource cell type complement resource design experience genetic manipulation imaging approach innovation insight interest kidney dysfunction kidney imaging medical schools member novel novel strategies paracrine personalized approach programs protein function receptor summer student tool undergraduate student

项目摘要

The critical role of the kidney in maintaining homeostatic balance, and the disorders of homeostasis that accompany diseases of the kidney and the associated loss of kidney function underscore the importance of this organ in human health. The Aims of our Pittsburgh Center for Kidney Research are (i) to provide critical resources for investigators throughout the US to advance studies of normal and abnormal kidney function and the cellular mechanisms that contribute to these states, (ii) to expand the diversity of the kidney research workforce by facilitating research efforts of early-stage investigators and established investigators who are new to kidney research, (iii) to educate students and community members about kidney function and disease through summer student enrichment program and a lay education program, and (iv) to speed research progress through active collaborations with other Consortium members. A central goal of our O'Brien Kidney National Resource Center is to provide investigators across the US with expertise in both classical and novel physiological approaches to dissect kidney function in normal and disease states. Our Cores will provide an integrated approach to address kidney-specific questions across a broad range of physical resolutions, ranging from molecules to whole animals using a variety of model systems amenable to genetic manipulation, and complement these studies using cutting edge imaging approaches tailored for an investigator’s specific needs. Our Resource Development Core will provide state-of-the-art imaging and develop new imaging tools and techniques to accelerate kidney-focused research, and complements our Biomedical Resource Cores that focus on Physiology and Model Systems. An Administrative Core provides oversight of the Center, its Core facilities, and the summer student enrichment and lay education programs. Our Center and Cores are led by a team of talented investigators with diverse research interests who have strong, collaborative research programs at the University of Pittsburgh and at the Icahn School of Medicine at Mount Sinai. Our Center is designed to realize our goal of providing kidney investigators with the knowledge and cutting- edge tools necessary to study normal and abnormal kidney function.

肾脏在维持体内平衡中所起的关键作用