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Pittsburgh Center for Kidney Research

匹兹堡肾脏研究中心

基本信息

批准号：
10747624
负责人：
Thomas R Kleyman
金额：
$ 96.98万
依托单位：
UNIVERSITY OF PITTSBURGH AT PITTSBURGH
依托单位国家：
美国
项目类别：
财政年份：
2023
资助国家：
美国
起止时间：
2023-09-01 至 2028-06-30
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10747624
关键词：
Acceleration Address Animals Area Biological Models Biology Biomedical Research Cell Culture Techniques Cells Cellular biology Collaborations Communities Complement Complex Core Facility Data Development Diet Disease Education Educational process of instructing Endocrine Ensure Epithelial Cells Equilibrium Equipment Event Faculty Fostering Friends Functional disorder Funding Goals Grant Health Homeostasis Human Image Imaging Device Imaging Techniques Individual Kidney Kidney Diseases Knowledge Manuscripts Modeling Molecular Nephrons Organ Organelles Organoids Pathway interactions Physiological Physiology Positioning Attribute Productivity Protocols documentation Pump Recording of previous events Regulation Renal function Research Research Activity Research Design Research Personnel Research Project Grants Resolution Resource Development Resources Role Scientist Signal Transduction Speed Students Sum Talents Training Tubular formation Universities Work Yeasts autocrine biomedical resource cell type complement resource design experience genetic manipulation imaging approach innovation insight interest kidney dysfunction kidney imaging medical schools member novel novel strategies paracrine personalized approach programs protein function receptor summer student tool undergraduate student

项目摘要

The critical role of the kidney in maintaining homeostatic balance, and the disorders of homeostasis that accompany diseases of the kidney and the associated loss of kidney function underscore the importance of this organ in human health. The Aims of our Pittsburgh Center for Kidney Research are (i) to provide critical resources for investigators throughout the US to advance studies of normal and abnormal kidney function and the cellular mechanisms that contribute to these states, (ii) to expand the diversity of the kidney research workforce by facilitating research efforts of early-stage investigators and established investigators who are new to kidney research, (iii) to educate students and community members about kidney function and disease through summer student enrichment program and a lay education program, and (iv) to speed research progress through active collaborations with other Consortium members. A central goal of our O'Brien Kidney National Resource Center is to provide investigators across the US with expertise in both classical and novel physiological approaches to dissect kidney function in normal and disease states. Our Cores will provide an integrated approach to address kidney-specific questions across a broad range of physical resolutions, ranging from molecules to whole animals using a variety of model systems amenable to genetic manipulation, and complement these studies using cutting edge imaging approaches tailored for an investigator’s specific needs. Our Resource Development Core will provide state-of-the-art imaging and develop new imaging tools and techniques to accelerate kidney-focused research, and complements our Biomedical Resource Cores that focus on Physiology and Model Systems. An Administrative Core provides oversight of the Center, its Core facilities, and the summer student enrichment and lay education programs. Our Center and Cores are led by a team of talented investigators with diverse research interests who have strong, collaborative research programs at the University of Pittsburgh and at the Icahn School of Medicine at Mount Sinai. Our Center is designed to realize our goal of providing kidney investigators with the knowledge and cutting- edge tools necessary to study normal and abnormal kidney function.

肾脏在维持体内平衡中的关键作用以及肾脏疾病伴随肾脏疾病和相关肾功能丧失的体内平衡强调这个器官对人类健康的重要性。我们匹兹堡中心的目标肾脏研究 (i) 为美国各地的研究人员提供关键资源推进正常和异常肾功能及其细胞机制的研究为这些国家做出贡献，（ii）通过以下方式扩大肾脏研究队伍的多样性促进早期研究人员和已建立的研究人员的研究工作肾脏研究新手，(iii) 对学生和社区成员进行有关肾功能的教育通过暑期学生强化计划和非专业教育计划来预防疾病，以及 (iv) 通过与其他联盟成员的积极合作加快研究进展。一个我们奥布莱恩肾脏国家资源中心的中心目标是为研究人员提供跨领域的服务美国在解剖肾脏的经典和新颖生理学方法方面拥有专业知识正常和疾病状态下的功能。我们的核心将提供一种综合方法来解决涵盖从分子到多种物理分辨率的肾脏特定问题使用适合基因操作的各种模型系统对整个动物进行研究，以及使用为研究人员量身定制的尖端成像方法来补充这些研究特定需求。我们的资源开发核心将提供最先进的成像和开发新的成像工具和技术以加速以肾脏为重点的研究，以及补充了我们专注于生理学和模型系统的生物医学资源核心。一个行政核心负责对中心、其核心设施和暑期学生的监督丰富和非专业教育计划。我们的中心和核心由一支才华横溢的团队领导具有不同研究兴趣、拥有强大的合作研究项目的研究人员在匹兹堡大学和西奈山伊坎医学院。我们的中心是旨在实现我们为肾脏研究人员提供知识和切割的目标研究正常和异常肾功能所必需的利器。