Mapping and manipulating fear prediction errors

映射和操纵恐惧预测错误

• 批准号: DP160100004
• 负责人: Prof Gavan McNally
• 金额: $ 41.63万
• 依托单位: The University of New South Wales
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2016
• 资助国家: 澳大利亚
• 起止时间: 2016-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP160100004
• 关键词: Mapping; manipulating; fear; prediction; errors

This project plans to use Pavlovian conditioning to map and then manipulate the brain architecture of fear prediction errors. It asks fundamental questions about how Pavlovian conditioning and associative learning enable us to learn to fear, to reduce fear, and to respond appropriately to danger. It aims to answer these questions with behavioural sophistication and previously unobtainable cell-type, temporal, and circuit-level precision. It aims to provide new insights into the mechanisms of Pavlovian conditioning, associative learning, and emotion: insights that are necessary to shape the next generation of theoretical accounts and practical applications.

该项目计划使用巴甫洛夫条件反射来绘制并操纵恐惧预测错误的大脑结构。它提出了一些基本问题，即巴甫洛夫条件反射和联想学习如何使我们学会恐惧，减少恐惧，并对危险做出适当的反应。它的目的是回答这些问题的行为复杂性和以前无法获得的细胞类型，时间和电路级精度。它旨在为巴甫洛夫条件反射，联想学习和情感的机制提供新的见解：这些见解对于塑造下一代理论解释和实际应用是必要的。