Mapping and manipulating circuits for relapse and abstinence

绘制和操纵复发和禁欲回路

• 批准号: nhmrc : GNT1138062
• 负责人: Prof Gavan McNally
• 金额: $ 67万
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2018
• 资助国家: 澳大利亚
• 起止时间: 2018-01-01 至 无数据
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/mapping-manipulating-circuits-relapse-abstinence/1348114
• 关键词: Mapping; manipulating; circuits; relapse; abstinence

Alcohol-use disorders and other drug addictions are chronically relapsing conditions. Current treatment approaches have only modest efficacy. Two advances are needed for genuine improvement. The first is parsing the brain mechanisms supporting abstinence and relapse at cellular as well as circuit levels. The second is targeting these circuits therapeutically with the same precision. This project contributes to the first advance and lays a basic science platform for next generation therapeutics.

酒精使用障碍和其他药物成瘾是慢性复发性疾病。目前的治疗方法只有适度的疗效。要真正改善，需要两个方面的进展。第一个是在细胞和电路水平上解析支持禁欲和复发的大脑机制。第二种是以同样的精度治疗性地瞄准这些回路。该项目贡献了第一个进展，并为下一代疗法奠定了基础科学平台。