Structural insights into adenosine receptors

腺苷受体的结构见解

• 批准号: DE180101165
• 负责人: Dr Alisa Glukhova
• 金额: $ 19.19万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Early Career Researcher Award
• 财政年份: 2018
• 资助国家: 澳大利亚
• 起止时间: 2018-01-01 至 2020-05-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DE180101165
• 关键词: Structural; insights; into; adenosine; receptors

This project aims to investigate mechanisms underlying ligand binding and signal transduction at G protein-coupled receptors (GPCRs) by utilising the adenosine receptor family as a model system. This interdisciplinary project will use structural biology, pharmacology and biochemistry. The expected outcomes include understanding ligand selectivity across the four adenosine receptor family members. This should provide significant benefits, such as advancement of fundamental knowledge that could also lead to therapeutic development.

本研究以腺苷受体家族为模型系统，探讨G蛋白偶联受体（GPCRs）的配体结合和信号转导机制。这个跨学科的项目将使用结构生物学，药理学和生物化学。预期的结果包括了解四个腺苷受体家族成员的配体选择性。这应该会带来显著的好处，例如基础知识的进步，也可能导致治疗的发展。