Optical tweezers for bio-nanotechnologies

用于生物纳米技术的光镊

• 批准号: DE180100810
• 负责人: Dr Carlo Bradac
• 金额: $ 20.54万
• 依托单位: University of Technology Sydney
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Early Career Researcher Award
• 财政年份: 2018
• 资助国家: 澳大利亚
• 起止时间: 2018-01-30 至 2020-07-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DE180100810
• 关键词: Optical; tweezers; bio; nanotechnologies

This project aims to develop a platform of diamond nanosensors and novel optical tweezers for probing cellular processes with single-molecule resolution, in vivo and over physiologically relevant time scales. In biomedicine, long-term imaging of single-molecules is beyond reach with existing bio-labels. The project combines the superior properties of nanodiamond biomarkers (brightness, stability, small size and non-toxicity), with new optical tweezers which exploit laser trapping of atoms to manipulate nanodiamonds in three-dimensional biological environments. By accessing smaller size and higher force regimes, the platform will improve bio-imaging and bio-manipulation techniques, and potentially advance pathogentracking and early detection of diseases.

该项目旨在开发一个金刚石纳米传感器和新型光镊平台，用于在体内和生理相关时间尺度上以单分子分辨率探测细胞过程。在生物医学中，单分子的长期成像是现有生物标记无法实现的。该项目结合了纳米金刚石生物标志物的上级特性（亮度，稳定性，小尺寸和无毒），以及利用激光捕获原子在三维生物环境中操纵纳米金刚石的新型光镊。通过获得更小的尺寸和更高的力机制，该平台将改进生物成像和生物操纵技术，并可能推进病原体跟踪和疾病的早期检测。