Optical tweezers for bio-nanotechnologies

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This project aims to develop a platform of diamond nanosensors and novel optical tweezers for probing cellular processes with single-molecule resolution, in vivo and over physiologically relevant time scales. In biomedicine, long-term imaging of single-molecules is beyond reach with existing bio-labels. The project combines the superior properties of nanodiamond biomarkers (brightness, stability, small size and non-toxicity), with new optical tweezers which exploit laser trapping of atoms to manipulate nanodiamonds in three-dimensional biological environments. By accessing smaller size and higher force regimes, the platform will improve bio-imaging and bio-manipulation techniques, and potentially advance pathogentracking and early detection of diseases.