IRON DEFICIENCY ANEMIA AND INFANT BEHAVIOR

缺铁性贫血和婴儿行为

• 批准号: 3073080
• 负责人: BETSY LOZOFF
• 金额: $ 5.31万
• 依托单位: CASE WESTERN RESERVE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1983
• 资助国家: 美国
• 起止时间: 1983-03-01 至 1988-02-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3073080
• 关键词: behavior test; blood chemistry; child behavior; cognition disorders; dietary iron; drug administration routes; infant human (0-1 year); intelligence tests; interpersonal relations; microcytic /hypochromic anemia; preschool child (1-5); psychophysiology

The proposed study will determine if iron therapy can correct rhe developmental deficits and behavioral abnormalities associated with iron deficiency anemia in infancey. The four aims of the project are: 1) to determine the level of iron depletion at which infant behavior is adversely affected, 2) to determine if there are differences between injectable and oral iron in behavioral effects, 3) to determine if iron therapy can completely correct the deficits, and 4) to confirm the specific pattern of behavioral disturbances observed in iron deficient anemic infants in our first study. The research design is a double-blind randomized controlled study of the short- and long-term behavioral and developmental effects of intramuscular and oral iron treatment. Two hundred one- to two-year old infants will be studies, 60 with iron deficiency anemia, 60 with iron deficiency with intermediate hemoglobin values, and 80 who are non-anemic, divided equally into iron depleted and iron replete groups. Their behavior and development will be assessed using sensitive quantitative behavior measures as well as overall tests of infant intelligence. To identify the level of iron depletion at which iron deficiency impairs infant development (Aim 1), pretreatment comparisons will be made in the groups of infants, whose iron status corresponds to the physiologic progression involved in becoming anemic from lack of iron. To accomplich (Aim 2,) the development and behavior of iron deficient infants treated with intramuscular iron will be compared to that of similar groups treated with oral iron, before treatment, after one week and after three months. Iron deficient infants will be compared with an iron replete control group before and after all babies become iron replete to determine if iron therapy can completely correct any behavioral deficits (Aim 3). Finally, (Aim 4) the study will confirm our previous results which demonstrated a specific pattern of impaired cognitive functions and a strong relationship between abnormal behavior and poor developmental test performance in iron deficient anemic infants. The results will guide practical pediatric and public health dexisions about preventive strategies, screening priorities, the level of iron deficiency requiring treatment, and the mode of therapy for iron deficiency anemia, the most common nutritional disorder in the world.

拟议的研究将确定铁疗法是否可以纠正 与铁相关的发育缺陷和行为异常 婴儿期缺乏性贫血。 该项目的四个目标是：1） 确定婴儿行为不良的铁缺乏水平 受影响，2) 确定注射剂和注射剂之间是否存在差异 口服铁剂对行为的影响，3) 确定铁剂疗法是否可以 完全纠正缺陷，4）确认具体模式 我们在缺铁性贫血婴儿中观察到的行为障碍 首先学习。 该研究设计是双盲随机对照 研究短期和长期的行为和发育影响 肌注和口服铁剂治疗。 两百一岁到两岁 婴儿将接受研究，60岁患有缺铁性贫血，60岁患有铁质 具有中等血红蛋白值的缺乏症和 80 名非贫血者， 平均分为缺铁组和富铁组。 他们的行为 将使用敏感的定量行为来评估发展 测量以及婴儿智力的整体测试。 为了识别 铁缺乏程度会损害婴儿发育 （目标 1），将在婴儿组中进行治疗前比较， 其铁状态与参与的生理进程相对应 因缺铁而贫血。 实现（目标2）的发展 肌内补铁治疗缺铁婴儿的行为和行为 与之前接受口服铁剂治疗的类似组进行比较 治疗一周后和三个月后。 缺铁婴儿 将在前后与补充铁的对照组进行比较 婴儿体内铁含量充足，以确定铁疗法是否可以完全 纠正任何行为缺陷（目标 3）。 最后，（目标 4）该研究将 证实我们之前的结果表明了特定的模式 认知功能受损与异常之间存在密切关系 缺铁性贫血患者的行为和发育测试表现不佳 婴儿。 结果将指导实际的儿科和公共卫生 关于预防策略、筛查优先事项、预防水平的决策 需要治疗的铁缺乏症以及铁治疗的方式 缺乏性贫血，世界上最常见的营养失调症。