权益分类	功能权益	普通用户	{{item.name}}会员
{{category.name}}	{{benefitItem.name}}

Understanding the home as a source of infection of AMR bacteria carried by dust by exploring hygiene practices in different home environments in Ghana

通过探索加纳不同家庭环境的卫生习惯，了解家庭是灰尘携带的 AMR 细菌的感染源

基本信息

批准号：
AH/R002177/1
负责人：
Emmanuel Tsekleves
金额：
$ 27.06万
依托单位：
Lancaster University
依托单位国家：
英国
项目类别：
Research Grant
财政年份：
2018
资助国家：
英国
起止时间：
2018 至无数据
项目状态：
已结题

来源：
https://gtr.ukri.org/projects?ref=AH%2FR002177%2F1
关键词：
Understanding home source infection AMR

项目摘要

The Dust Bunny project will apply design methods coupled with microbiological analyses to address issues of home-based infections in Ghana, particularly those carrying antimicrobial resistance, resulting in a reduction of infection and in positive increase of health outcomes.Bacteria found in the natural and built environment (e.g. homes, schools, hospitals, etc.) are building up a resistance to drugs -changing to protect themselves against antibiotics. What this means is that in the not-too-distant future, something as simple as a minor cut infection could become life-threatening. This is such a concern that antimicrobial resistance (AMR) is now considered a global health crisis, far surpassing outbreaks of diseases such as Ebola and as real as climate change. This is even more evident and critical in developing countries in Africa, such as in Ghana, where there are a great number of deaths from infectious diseases. Bacteria are made up of pathogens (bad germs) and non-pathogens (good germs) and are generally scattered across the home. Most surfaces in the home are covered to a certain degree with bacteria, but unlike fixed surfaces such as kitchen work surfaces and furniture, dust can move more easily around different parts of the home and therefore presents a major route for human exposure to bacterial infections. Despite being clear evidence for microbial exposure and infection transmission within the home, there has been less research effort invested in understanding the home environment, due to difficulty of conducting detailed studies. Although the transmission routes by dust in the home environment are well known, what has not been studied is how to prevent bacterial infection at home and thereby reduce resistance.Particularly in developing countries, such as Ghana, social inequalities mean a range of different quality and types of homes; this combined with often poor levels of domestic hygiene that is influenced by a number of economic, educational and religion factors, contributes to the spread of infectious diseases. Although there are hygiene guidelines available for preventing infection in the home environment, these are targeted at hygiene professionals and do not reach the everyday household in Ghana. There is therefore a much-required and unmet need to identify, understand and develop domestic hygiene practices that are relevant to different home environments, educational and cultural backgrounds in developing countries, such as in Ghana, in order to reduce exposure to bacteria pathogens and thereby exposure to resistance forms.Within this context, the Dust Bunny project aims at developing an understanding of the home as a source of infection of bacteria, resistant to antibiotics, found and carried by dust. This will be done by exploring hygiene practices across different home environments in Ghana, with the ultimate aim to reduce bacterial infection in the home environment thereby reducing AMR. Understanding the hygiene practices in the household and interactions with airborne AMR bacteria will serve as a first step to designing appropriate education/information dissemination materials for various sections of the Ghanaian population as well as other low- and middle-income countries in Africa. Dust Bunny, uniquely combines design research and microbiology to provide an informed assessment of societal practices in domestic cleanliness and novel solution to reduce infections in the home. The project team includes Imagination@Lancaster -an internationally leading research institution in design research- and the Noguchi Memorial Institute for Medical Research -a research centre of excellence and the prime biomedical research institution in Ghana, involved with the Ghana Health Service and Ministry of Health in providing the evidence to effect policy changes.

“灰尘兔子”项目将采用设计方法，结合微生物分析，解决加纳家庭感染问题，特别是那些携带抗菌素耐药性的家庭感染问题，从而减少感染，积极提高健康成果。正在建立对药物的抵抗力--改变以保护自己免受抗生素的侵害。这意味着在不久的将来，像轻微的伤口感染这样简单的事情可能会危及生命。这是一个如此令人担忧的问题，以至于抗菌素耐药性（AMR）现在被认为是一场全球健康危机，远远超过埃博拉等疾病的爆发，与气候变化一样真实的。这一点在非洲发展中国家，如加纳，更为明显和关键，那里有大量人死于传染病。细菌由病原体（坏细菌）和非病原体（好细菌）组成，通常分散在家中。家庭中的大多数表面都在一定程度上覆盖着细菌，但与厨房工作表面和家具等固定表面不同，灰尘可以更容易地在家庭的不同部分移动，因此是人类暴露于细菌感染的主要途径。尽管有明确的证据表明家庭内的微生物暴露和感染传播，但由于难以进行详细的研究，在了解家庭环境方面投入的研究工作较少。虽然家庭环境中灰尘的传播途径是众所周知的，但尚未研究的是如何防止家庭中的细菌感染，从而减少抗药性，特别是在加纳等发展中国家，社会不平等意味着各种不同质量和类型的家庭;再加上受经济、教育和宗教因素影响的家庭卫生水平往往很差，有助于传染病的传播。虽然有预防家庭环境感染的卫生准则，但这些准则是针对卫生专业人员的，并没有普及到加纳的日常家庭。因此，在加纳等发展中国家，迫切需要查明、了解和发展与不同家庭环境、教育和文化背景相关的家庭卫生习惯，以减少对细菌病原体的接触，从而减少对耐药性形式的接触。灰尘兔子项目的目的是使人们了解家庭是由灰尘发现和携带的对抗生素有抗药性的细菌的感染源。这将通过探索加纳不同家庭环境的卫生习惯来实现，最终目标是减少家庭环境中的细菌感染，从而减少AMR。了解家庭卫生习惯以及与空气中AMR细菌的相互作用将成为为加纳人口的各个部分以及非洲其他低收入和中等收入国家设计适当的教育/信息传播材料的第一步。Dust Bunny独特地结合了设计研究和微生物学，为家庭清洁和减少家庭感染的新解决方案的社会实践提供了明智的评估。该项目团队包括Imagination@兰开斯特-一个国际领先的设计研究机构-和野口纪念医学研究所-一个卓越的研究中心和加纳主要的生物医学研究机构，与加纳卫生服务和卫生部一起为政策变化提供证据。

项目成果

期刊论文数量（10）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

ImaginationLancaster:Open-Ended, Anti-Disciplinary, Diverse

ImaginationLancaster：开放式、反纪律、多元化

DOI：
10.1016/j.sheji.2018.11.001
发表时间：
2018
期刊：
She Ji: The Journal of Design, Economics, and Innovation
影响因子：
0
作者：
R. Cooper;Nick Dunn;P. Coulton;S. Walker;P. Rodgers;Leon Cruikshank;Emmanuel Tsekleves;D. Hands;Roger Whitham;C. Boyko;Daniel Richards;Bijan Aryana;S. Pollastri;M. A. L. Escalante;Bran Knowles;C. Lopez;P. Cureton;C. Coulton
通讯作者：
C. Coulton

Handbook of Global Health

全球健康手册

DOI：
10.1007/978-3-030-05325-3_3-1
发表时间：
2020
期刊：
影响因子：
0
作者：
Ghani F
通讯作者：
Ghani F

Developing home cleaning intervention through community engagement to reduce infections and antimicrobial resistance in Ghanaian homes.

DOI：
10.1038/s41598-023-37317-4
发表时间：
2023-06-28
期刊：
SCIENTIFIC REPORTS
影响因子：
4.6
作者：
Tsekleves, Emmanuel;de Souza, Dziedzom;Pickup, Roger;Ahorlu, Collins;Darby, Andy
通讯作者：
Darby, Andy

Combining design research with microbiology to tackle drug-resistant infections in different home environments in Ghana: Challenging the boundaries of design thinking