Harnessing neural plasticity with brain stimulation

通过大脑刺激来利用神经可塑性

• 批准号: DE180100741
• 负责人: Dr Nigel Rogasch
• 金额: $ 24.01万
• 依托单位: The University of Adelaide
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Early Career Researcher Award
• 财政年份: 2018
• 资助国家: 澳大利亚
• 起止时间: 2018-01-08 至 2021-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DE180100741
• 关键词: Harnessing; neural; plasticity; brain; stimulation

This project aims to investigate the links between the molecular mechanisms underlying brain plasticity and the effects of non-invasive brain stimulation. It will use a novel approach that integrates genetics, electrophysiology and biological modelling. Plasticity underpins all learning, memory and aging. Brain stimulation can drive plasticity in humans, but these effects are extremely difficult to harness and vary widely between people. Expected outcomes include a critical understanding of the fundamental mechanisms governing plasticity. This will provide significant benefits such as the development of individually optimised brain stimulation protocols, enabling tailored, reliable approaches to address brain function and cognition.

该项目旨在研究大脑可塑性的分子机制与非侵入性大脑刺激的效果之间的联系。它将使用一种整合遗传学、电生理学和生物建模的新方法。可塑性是所有学习、记忆和衰老的基础。大脑刺激可以促进人类的可塑性，但这些影响极难驾驭，而且因人而异。预期成果包括对控制可塑性的基本机制的批判性理解。这将提供显着的好处，例如开发单独优化的大脑刺激方案，从而实现定制的、可靠的方法来解决大脑功能和认知问题。